Results 31 to 40 of about 5,780 (131)

Donor species complement after liver xenotransplantation: The mechanism of protection from hyperacute rejection [PDF]

, 1994
Hamster hearts transplanted into stable rat recipients of hamster livers (OLT rats) were hyperacutely rejected after transfer with unaltered rat antihamster hyperimmune serum (HS).
Celli, S, Demetris, AJ, Fung, JJ, Pan, F, Starzl, TE, Tsugita, M, Valdivia, LA   +6 more
core   +1 more source

Mouse developmental defects, but not paraganglioma tumorigenesis, upon conditional Complex II loss in early Sox10+ cells

FASEB BioAdvances, Volume 6, Issue 9, Page 327-336, September 2024.
In humans, paragangliomas (PGLs) form in certain neuroendocrine cells that have lost succinate dehydrogenase, an enzyme of the tricarboxylic acid cycle. Conditional SDH deficiency has not yet been shown to drive PGL formation in mice, limiting available research tools. Here, prenatal SDH knockout in small numbers of SOX10+ precursors of adrenal medulla
Elizabeth P. Lewis, Fatimah Al Khazal, Brandon Wilbanks, Naomi M. Gades, Patricia Ortega‐Sáenz, José López‐Barneo, Igor Adameyko, L. James Maher III   +7 more
wiley   +1 more source

Metformin treatment results in distinctive skeletal muscle mitochondrial remodeling in rats with different intrinsic aerobic capacities

Aging Cell, Volume 23, Issue 9, September 2024.
We tested if the effects of metformin were context specific in skeletal muscle using a rat model (high‐capacity and low‐capacity runners: HCRs/LCRs) with a divide in intrinsic aerobic capacity. Metformin lowered mitochondrial respiration, but a washout of metformin resulted in a doubling of respiratory capacity in HCRs, with no effect in LCRs.
Matthew P. Bubak, Arik Davidyan, Colleen L. O'Reilly, Samim A. Mondal, Jordan Keast, Stephen M. Doidge, Agnieszka K. Borowik, Michael E. Taylor, Evelina Volovičeva, Michael T. Kinter, Steven L. Britton, Lauren G. Koch, Michael B. Stout, Tommy L. Lewis Jr, Benjamin F. Miller   +14 more
wiley   +1 more source

Relative contribution of direct and indirect allorecognition in developing tolerance after liver transplantation [PDF]

, 2008
The interaction of donor passenger leukocytes and host leukocytes in recipient secondary lymphoid tissues during the early posttransplantation period is crucial in directing host immune reactions toward allograft rejection or acceptance.
Akdis, Benichou, Buiting, Cebon, Csencsits, Dai, Demetris, Demetris, Demetris, Fleisch, Ganta, Gould, Heeger, Huitinga, Ichikawa, Josien, Jurcevic, Ko, Konieczny, Lakkis, Larsen, Lechler, Mellor, Munn, Murase, Murase, Murase, Nakao, Neto, Nikolic, Okuda, Rabinovich, Raisanen-Sokolowski, Sawitzki, Sekine, Sims, Slegers, Smith, Starzl, Starzl, Sun, Talmage, Van Rooijen, Van Rooijen, Van Rooijen, Wu, Yagihashi, Yan, Zhang   +48 more
core   +2 more sources

Progress in experimental models to investigate the in vivo and in vitro antidiabetic activity of drugs

Animal Models and Experimental Medicine, Volume 7, Issue 3, Page 297-309, June 2024.
Abstract Diabetes mellitus is one of the world's most prevalent and complex metabolic disorders, and it is a rapidly growing global public health issue. It is characterized by hyperglycemia, a condition involving a high blood glucose level brought on by deficiencies in insulin secretion, decreased activity of insulin, or both.
Yasodha Krishna Janapati, Sunil Junapudi
wiley   +1 more source

Combined immunosuppressive therapy with low dose FK506 and antimetabolites in rat allogeneic heart transplantation [PDF]

, 1994
Following rat heterotopic heart allotransplantation, low to lethal doses of the antimetabolites mizoribine (MIZ), RS-61443 (RS), and AZA were given alone or in combination with subtherapeutic doses of FK506 (0.04 mg/kg/day) for 14 days after ...
Fujisaki, S, Irish, W, Miyazawa, H, Murase, N, Starzl, TE, Tanabe, M, Todo, S   +6 more
core   +1 more source

Tests of evolutionary and genetic rescue using flour beetles, Tribolium castaneum, experimentally evolved to thermal conditions

Ecology and Evolution, Volume 14, Issue 5, May 2024.
We use experimental evolution to test the effects of demographic and evolutionary rescue in populations of Tribolium castaneum previously adapted to high temperature and kept at small population sizes. We find no evidence of rescue in these populations and discuss the results in the context of conservation intervention.
Rebecca Lewis, Michael D. Pointer, Lucy Friend, Matthew J. G. Gage, Lewis G. Spurgin   +4 more
wiley   +1 more source

High-resolution genome screen for bone mineral density in heterogeneous stock rat [PDF]

, 2014
We previously demonstrated that skeletal mass, structure, and biomechanical properties vary considerably in heterogeneous stock (HS) rat strains. In addition, we observed strong heritability for several of these skeletal phenotypes in the HS rat model ...
Alam, Imranul, Baud, Amelie, Blázquez, Gloria, Cañete, Toni, Dieze, Margarita, Díaz-Morán, Sira, Econs, Michael J., Fernández-Teruel, Alberto, Foroud, Tatiana, Johannesson, Martina, Koller, Daniel L., López-Aumatell, Regina, Martínez-Membrives, Esther, Olsson, Tomas, Stridh, Pernilla, Tobeña, Adolf   +15 more
core   +1 more source

The origin, connectivity, and individual specialization of island wolves after deer extirpation

Ecology and Evolution, Volume 14, Issue 4, April 2024.
We applied DNA metabarcoding and SNP genotyping to quantify variation in marine foraging behavior within wolf packs, among sexes, and individuals using 957 scats collected from an island and the adjacent mainland from 2016 to 2022. Island wolves consistently consumed sea otters while mainland wolves fed mainly on ungulates and voles with more variation
Charlotte E. Eriksson, Gretchen H. Roffler, Jennifer M. Allen, Alex Lewis, Taal Levi   +4 more
wiley   +1 more source

Limits to species distributions on tropical mountains shift from high temperature to competition as elevation increases

Ecological Monographs, Volume 94, Issue 1, February 2024.
Abstract Species turnover with elevation is a widespread phenomenon and provides valuable information on why and how ecological communities might reorganize as the climate warms. It is commonly assumed that species interactions are more likely to set warm range limits, while physiological tolerances determine cold range limits.
Jinlin Chen, Owen T. Lewis
wiley   +1 more source