Results 61 to 70 of about 129,705 (270)

Squamate ventricular cardiomyocytes: Ploidy, proliferation, and heart muscle cell size in the leopard gecko (Eublepharis macularius)

Developmental Dynamics, EarlyView.
Abstract Background While heart function is broadly conserved across vertebrates, the cellular phenotype of muscle cells (cardiomyocytes) varies across taxa and throughout ontogeny. Emerging evidence suggests that some attributes may correlate with the capacity for spontaneous cardiomyocyte replacement following injury.
Kathy Jacyniak, Karemna Barrera Jaimes, Minh Hanh Doan, Jordyn M. Chartrand, Matthew K. Vickaryous   +4 more
wiley   +1 more source

Superovulation with an anti-inhibin monoclonal antibody improves the reproductive performance of rat strains by increasing the pregnancy rate and the litter size

Scientific Reports
Rats are multiparous rodents that have been used extensively in research; however, the low reproductive performance of some rat strains hampers the broader use of rats as a biomedical model.
Keiji Mochida, Kohtaro Morita, Yoshio Sasaoka, Kento Morita, Hitoshi Endo, Ayumi Hasegawa, Masahide Asano, Atsuo Ogura   +7 more
doaj   +1 more source

Detection and Mapping of Quantitative Trait Loci that Determine Responsiveness [PDF]

, 2004
Exposure to 70% N2O evokes a robust antinociceptive effect in C57BL/6 (B6) but not in DBA/2 (D2) inbred mice. This study was conducted to identify quantitative trait loci (QTL) in the mouse genome that might determine responsiveness to N2O.
Belknap, John K., Ellenberger, E. A., Mueller, Janet L., Quock, Raymond M., Vaughn, Linda K.   +4 more
core   +1 more source

Lean ZSF1 rats in basic research on heart failure with preserved ejection fraction

ESC Heart Failure, Volume 12, Issue 2, Page 1474-1478, April 2025.
Abstract Aims ZSF1 obese rats harbouring two mutant leptin receptor alleles (Leprcp and Leprfa) develop metabolic syndrome and heart failure with preserved ejection fraction (HFpEF), making them a widely used animal model in cardiometabolic research.
Petra Büttner, Antje Augstein, Mahmoud Abdellatif, André Lourenço, Adelino Leite‐Moreira, Inês Falcão‐Pires, Sarah Werner, Holger Thiele, Simon Sedej, Antje Schauer, Volker Adams   +10 more
wiley   +1 more source

Genetic divergence and the genetic architecture of complex traits in chromosome substitution strains of mice

BMC Genetics, 2012
Background The genetic architecture of complex traits strongly influences the consequences of inherited mutations, genetic engineering, environmental and genetic perturbations, and natural and artificial selection.
Spiezio Sabrina H, Takada Toyoyuki, Shiroishi Toshihiko, Nadeau Joseph H   +3 more
doaj   +1 more source

Intestinal microbiome alterations in pediatric epilepsy: Implications for seizures and therapeutic approaches

Epilepsia Open, EarlyView.
Abstract The intestinal microbiome plays a pivotal role in maintaining host health through its involvement in gastrointestinal, immune, and central nervous system (CNS) functions. Recent evidence underscores the bidirectional communication between the microbiota, the gut, and the brain and the impact of this axis on neurological diseases, including ...
Teresa Ravizza, Greta Volpedo, Antonella Riva, Pasquale Striano, Annamaria Vezzani   +4 more
wiley   +1 more source

A rat model of early stage osteonecrosis induced by glucocorticoids

Journal of Orthopaedic Surgery and Research, 2011
Background Glucocorticoid (GC)-induced osteonecrosis (ON) is an important complication of medical therapy. The exact pathomechanisms of ON has not been clearly elucidated.
Kerachian Mohammad, Harvey Edward J, Cournoyer Denis, Chow Terry Y, Nahal Ayoub, Séguin Chantal   +5 more
doaj   +1 more source

Inhalation of welding fumes reduced sperm counts and high fat diet reduced testosterone levels; differential effects in Sprague Dawley and Brown Norway rats

Particle and Fibre Toxicology, 2020
Background Previous studies have shown that inhalation of welding fumes may induce pulmonary and systemic inflammation and organ accumulation of metal, to which spermatogenesis and endocrine function may be sensitive.
Astrid Skovmand, Aaron Erdely, James M. Antonini, Timothy R. Nurkiewicz, Mohammad Shoeb, Tracy Eye, Vamsi Kodali, Katrin Loeschner, Janja Vidmar, Jørgen S. Agerholm, Sandra Goericke-Pesch, Ulla Vogel, Karin S. Hougaard   +12 more
doaj   +1 more source

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

Adapting Genotyping-by-Sequencing and Variant Calling for Heterogeneous Stock Rats

G3: Genes, Genomes, Genetics, 2020
The heterogeneous stock (HS) is an outbred rat population derived from eight inbred rat strains. HS rats are ideally suited for genome wide association studies; however, only a few genotyping microarrays have ever been designed for rats and none of them ...
Alexander F. Gileta, Jianjun Gao, Apurva S. Chitre, Hannah V. Bimschleger, Celine L. St. Pierre, Shyam Gopalakrishnan, Abraham A. Palmer   +6 more
doaj   +1 more source