Results 61 to 70 of about 97,044 (222)

Genetic Background Influences Acute Response to TBI in Kindling-Susceptible, Kindling-Resistant, and Outbred Rats

Frontiers in Neurology, 2020
We hypothesized that the acute response to traumatic brain injury (TBI) shares mechanisms with brain plasticity in the kindling model. Utilizing two unique, complementary strains of inbred rats, selected to be either susceptible or resistant to seizure ...
Robert J. Kotloski, Robert J. Kotloski, Paul A. Rutecki, Paul A. Rutecki, Thomas P. Sutula   +4 more
doaj   +1 more source

Strain-Dependent Differences in Oxygen-Induced Retinopathy in the Inbred Rat

Investigative Opthalmology & Visual Science, 2005
To examine the susceptibilities of different rat strains to oxygen-induced retinopathy, a model of human retinopathy of prematurity.Litters of newborn rats of five inbred strains (Fischer 344 [F344], Dark Agouti [DA], Sprague-Dawley [SD], Wistar-Furth [WF], Lewis [LEW]) and one outbred strain (Hooded Wistar [HW]) were maintained in room air or were ...
van Wijngaarden, Peter, Coster, Douglas John, Brereton, Helen Mary, Gibbins, Ian Lewis, Williams, Keryn Anne   +4 more
openaire   +4 more sources

Critical insights into the potential risks of antipsychotic drugs to fish, including through effects on behaviour

Biological Reviews, EarlyView.
ABSTRACT Antipsychotic drugs (APDs) are a diverse class of neuroactive pharmaceuticals increasingly detected in surface and ground waters globally. Some APDs are classified as posing a high environmental risk, due, in part, to their tendency to bioaccumulate in wildlife, including fish.
Gabrielle Wasser‐Bennett, A. Ross Brown, Samuel K. Maynard, Stewart F. Owen, Charles R. Tyler   +4 more
wiley   +1 more source

Digit ratio (2Dratio4D) differences between 20 strains of inbred mice.

PLoS ONE, 2009
The second to fourth digit ratio (2Dratio4D) is sexually differentiated in a variety of species, including humans, rats, birds, and lizards. In humans, this ratio tends to be lower in males than in females.
Reginia H Y Yan, Mark Bunning, Douglas Wahlsten, Peter L Hurd   +3 more
doaj   +1 more source

Using liquid chromatography mass spectrometry (LC-MS) to assess the effect of age, high-fat diet, and rat strain on the liver metabolome.

PLoS ONE, 2020
The goal of this study was to use liquid chromatography mass spectrometry to assess metabolic changes of two different diets in three distinct rat strains.
Greg Boyce, Mohammad Shoeb, Vamsi Kodali, Terence Meighan, Jenny R Roberts, Aaron Erdely, Michael Kashon, James M Antonini   +7 more
doaj   +1 more source

Differences in response to anaesthetics and analgesics between inbred rat strains

Laboratory Animals, 2007
Differences in response to analgesic and anaesthetic drugs can partly be attributed to variations in the genetic background of experimental animals. This study was carried out to determine differences in the response of inbred rat strains to a selection of analgesics and drugs used in anaesthetic protocols. A cross between the most contrasting strains
Avsaroglu, H., van der Sar, A.S., van Lith, H.A., van Zutphen, L.F.M., Hellebrekers, L.J.   +4 more
openaire   +5 more sources

PAC‐FOS: A novel translational concordance framework identifies preclinical seizure models with highest predictive validity for clinical focal onset seizures

Epilepsia, EarlyView.
Abstract Objective Central to the development of novel antiseizure medications (ASMs) is testing of antiseizure activity in preclinical models. Although various well‐established models exist, their predictive validity across the spectrum of clinical epilepsies has been less clear.
Lyndsey L. Anderson, Kristopher M. Kahlig, Melissa L. Barker‐Haliski, Lillian G. Matthews, Hamish D. Toop, Brian Hannigan, Jacqueline French, H. Steve White, Marcio Souza, Steven Petrou   +9 more
wiley   +1 more source

Profiles of parents' upward and downward comparisons and their associations with parenting

Family Relations, EarlyView.
ABSTRACT Objective The aim of this study was to explore whether there are naturally occurring groups of parents who display different profiles of upward (i.e., comparing with those better off) and downward (i.e., comparing with those worse off) social comparisons, and if these differ on parental symptoms, self‐efficacy, and positive parenting behaviors.
Lovisa Burman, Johanna Jonsson, Terese Glatz, Bénédicte Mouton   +3 more
wiley   +1 more source

Mitochondrial DNA phylogeography of the Norway rat.

PLoS ONE, 2014
Central Eastern Asia, foremost the area bordering northern China and Mongolia, has been thought to be the geographic region where Norway rats (Rattus norvegicus) have originated.
Ying Song, Zhenjiang Lan, Michael H Kohn
doaj   +1 more source

A genetic linkage map of the rat derived from recombinant inbred strains

Mammalian Genome, 1996
We have constructed a genetic linkage map in the rat by analyzing the strain distribution patterns of 500 genetic markers in a large set of recombinant inbred strains derived from the spontaneously hypertensive rat and the Brown-Norway rat (HXB and BXH recombinant inbred strains).
Pravenec, M, Gauguier, D, Schott, Jean-Jacques, Buard, J, Kren, V, Bílá, V, Szpirer, C, Szpirer, J, Wang, J M, Huang, He, St Lezin, E, Spence, M A, Flodman, P, Printz, M, Lathrop, G M, Vergnaud, Gilles, Kurtz, T W   +16 more
openaire   +4 more sources