Results 71 to 80 of about 97,044 (222)

‘Disease‐smart’ outcrossing can enhance individual fitness and increase survival via immune priming against pathogens: New approaches to strengthen genetic rescue efforts

open access: yesInsect Conservation and Diversity, EarlyView.
Our study provides a proof of concept for combining immune priming with assisted migration for insect conservation. Introducing genetically diverse, immune‐primed migrants improves both pathogen resistance and reproductive success in inbred individuals.
Enakshi Ghosh   +2 more
wiley   +1 more source

Genomic organization of the rat Clock gene and sequence analysis in inbred rat strains

open access: yesGenomics, 2006
While mutations in genes that function in the core molecular clock may disrupt circadian periodicity, their relevance to diurnal variation in metabolic, cardiovascular, and respiratory function is unknown. The circadian Clock gene product is an essential regulator of central and peripheral circadian rhythms in mammals.
Woon, P   +7 more
openaire   +4 more sources

Adsorption of antigen to polymeric nanoparticles enhances cytotoxic T‐cell responses and anti‐tumor immunity by targeting conventional type 1 dendritic cells

open access: yesImmunology &Cell Biology, EarlyView.
Therapeutic cancer vaccines require CD8+ T‐cell activation for efficacy. This response can be enhanced by rationally designing polymeric nanoparticle adjuvants. The importance of antigen location for the adjuvanticity of polymeric nanoparticles has not been fully resolved.
Jorge Huete‐Carrasco   +6 more
wiley   +1 more source

New Wistar Kyoto and spontaneously hypertensive rat transgenic models with ubiquitous expression of green fluorescent protein

open access: yesDisease Models & Mechanisms, 2016
The Wistar Kyoto (WKY) rat and the spontaneously hypertensive (SHR) rat inbred strains are well-established models for human crescentic glomerulonephritis (CRGN) and metabolic syndrome, respectively.
Ana Isabel Garcia Diaz   +6 more
doaj   +1 more source

Development of cytosine and adenine base editors for maize precision breeding

open access: yesJournal of Integrative Plant Biology, EarlyView.
A series of maize cytosine and adenine base editors was developed using various deaminase variants, enabling efficient multiplex genome editing in maize. Precise editing of the ZmACC1/2 genes generated herbicide‐tolerant maize germplasm, offering a solution for weed management in maize‐soybean intercropping systems.
Xiao Fu   +8 more
wiley   +1 more source

Empowering Regional Conservation: Genetic Diversity Assessments as a Tool for Eelgrass Management

open access: yesMolecular Ecology, EarlyView.
ABSTRACT To halt the loss of biodiversity, collaboration among scientists, managers and decision‐makers is vital. Although biodiversity loss is a global problem, management actions influencing diversity are often on a local to regional scale. Our study is an example of a regional conservation genomic assessment developed in collaboration between ...
Ellika Faust   +5 more
wiley   +1 more source

Sex differences in corneal neovascularization in response to superficial corneal cautery in the rat.

open access: yesPLoS ONE, 2019
Sex-based differences in susceptibility have been reported for a number of neovascular ocular diseases. We quantified corneal neovascularization, induced by superficial silver nitrate cautery, in male and female inbred albino Sprague-Dawley, inbred ...
Yazad D Irani   +6 more
doaj   +1 more source

Genomic Insights Into the Origin, Decline and Recovery of the Once Critically Endangered Iberian Lynx

open access: yesMolecular Ecology, EarlyView.
ABSTRACT The Iberian lynx was at the brink of extinction by the year 2000 but has since then, and thanks to intensive conservation measures, gone through a remarkable recovery, providing a much‐welcomed and encouraging conservation success story.
José A. Godoy   +13 more
wiley   +1 more source

Chemically Induced Oncogenesis in the Peripheral Nervous System Is Suppressed in Congenic BDIX.BDIV-Mss1 and -Mss7 Rats

open access: yesG3: Genes, Genomes, Genetics, 2016
Human malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive soft-tissue sarcomas with a poor prognosis that arise either in the context of neurofibromatosis 1 or sporadically.
Bernd Koelsch   +5 more
doaj   +1 more source

A Comparative Study of Puberty, and Plasma Gonadotropin and Testicular Hormone Levels in Two Inbred Strains of Hatano Rats

open access: yes, 2002
We found that two inbred strains of Hatano rats bred selectively for shuttlebox avoidance responses, had different characteristics of responses to stress and adrenal function.
Masako Sato   +7 more
semanticscholar   +1 more source

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