Results 71 to 80 of about 49,631 (197)

Restoring failed inhibition in the substantia nigra pars reticulata suppresses absence seizures in rats

open access: yesEpilepsia, EarlyView.
Abstract Objective For over four decades, the substantia nigra pars reticulata (SNr) has been recognized as a critical structure in the modulation of seizure activity. Pharmacological and optogenetic inhibition of the SNr produces robust seizure suppression in a range of seizure models.
Devin Palmer, Patrick A. Forcelli
wiley   +1 more source

The power of a stewardship mind: Reorienting organizations around the duty to care to better address grand challenges

open access: yesInternational Journal of Management Reviews, EarlyView.
Abstract The present article presents an integrative review related to stewardship in all the business and management disciplines, from its initial development in 1980 to the present. Specifically, we applied a latent Dirichlet allocation‐based topic modelling analysis to almost 1200 articles, seeking to creatively synthesize the concept of stewardship
Debora Casoli   +3 more
wiley   +1 more source

New Wistar Kyoto and spontaneously hypertensive rat transgenic models with ubiquitous expression of green fluorescent protein

open access: yesDisease Models & Mechanisms, 2016
The Wistar Kyoto (WKY) rat and the spontaneously hypertensive (SHR) rat inbred strains are well-established models for human crescentic glomerulonephritis (CRGN) and metabolic syndrome, respectively.
Ana Isabel Garcia Diaz   +6 more
doaj   +1 more source

Use of Cluster Analysis for Identifying Metafounders

open access: yesJournal of Animal Breeding and Genetics, EarlyView.
ABSTRACT In the metafounder approach, the relationship matrix of metafounders, Γ$$ \boldsymbol{\Gamma} $$ is used to transfer information on relationships between pedigree founders into the numerator relationship matrix A$$ \mathbf{A} $$, creating matrix AΓ$$ {\mathbf{A}}^{\boldsymbol{\Gamma}} $$.
Christine Anglhuber   +5 more
wiley   +1 more source

The maize mitogen‐activated protein kinase kinase kinase gene ZmMAPKKK45 is associated with multiple disease resistance

open access: yesNew Phytologist, EarlyView.
Summary Southern leaf blight (SLB), caused by the necrotrophic fungus Cochliobolus heterostrophus, is a major foliar disease of maize (Zea mays) world‐wide. A genome‐wide association study was performed to dissect the genetic basis of SLB resistance in maize. Functional validation was performed using mutant and transgenic analyses.
Tao Zhong   +8 more
wiley   +1 more source

Sex differences in corneal neovascularization in response to superficial corneal cautery in the rat.

open access: yesPLoS ONE, 2019
Sex-based differences in susceptibility have been reported for a number of neovascular ocular diseases. We quantified corneal neovascularization, induced by superficial silver nitrate cautery, in male and female inbred albino Sprague-Dawley, inbred ...
Yazad D Irani   +6 more
doaj   +1 more source

ClAPRT3‐Mediated Adenine Salvage Pathway Enhances Purine Metabolites to Sustain Seed Vigour During Selfing in Cunninghamia lanceolata

open access: yesPlant Biotechnology Journal, EarlyView.
ABSTRACT Selfing often causes inbreeding depression, especially during seed and seedling stages. However, some selfed progeny show low inbreeding depression with enhanced vigour, differing from inbred counterparts. This study investigates the molecular mechanisms maintaining seed vigour during selfing in Cunninghamia lanceolata.
Houyin Deng   +13 more
wiley   +1 more source

BEHAVIOR OF RAT NEONATES WITH INHERITED STRESS-INDUCED ARTERIAL HYPERTENSION

open access: yesВавиловский журнал генетики и селекции, 2015
The present work concerns the development of locomotor activity, rates of weight gain, vibrissa growth, and time of eyelid opening in two inbred rate strains in the early development.
I. O. Meshkov   +2 more
doaj  

Chemically Induced Oncogenesis in the Peripheral Nervous System Is Suppressed in Congenic BDIX.BDIV-Mss1 and -Mss7 Rats

open access: yesG3: Genes, Genomes, Genetics, 2016
Human malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive soft-tissue sarcomas with a poor prognosis that arise either in the context of neurofibromatosis 1 or sporadically.
Bernd Koelsch   +5 more
doaj   +1 more source

Trans‐QTL Alliance of HKT1 and PHL7 Modulate Salinity Stress Tolerance and Enhance Crop Yield Endurance

open access: yesPlant Biotechnology Journal, EarlyView.
ABSTRACT Salinity stress can cause significant yield losses in crops because of its major impact on reproductive success. The complexity of salinity stress responses, particularly their tissue‐ and cell‐specific regulation, continues to challenge the translation of molecular insights into tangible crop yield improvements.
Jitendra K. Mohanty   +8 more
wiley   +1 more source

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