Results 81 to 90 of about 97,044 (222)

Sex‐Dependent Influence of Major Histocompatibility Complex Diversity on Fitness in a Social Mammal

Molecular Ecology, EarlyView.
ABSTRACT Parasite infections affect males and females differently across a wide range of species, often due to differences in immune responses. Generally, females tend to have stronger immune defences and lower parasite loads than males. The major histocompatibility complex (MHC) plays a crucial role in the adaptive immune response, and extensive ...
Nadine Schubert, Hazel J. Nichols, Francis Mwanguhya, Robert Businge, Solomon Kyambulima, Kenneth Mwesige, Joseph I. Hoffman, Michael A. Cant, Jamie C. Winternitz   +8 more
wiley   +1 more source

BEHAVIOR OF RAT NEONATES WITH INHERITED STRESS-INDUCED ARTERIAL HYPERTENSION

Вавиловский журнал генетики и селекции, 2015
The present work concerns the development of locomotor activity, rates of weight gain, vibrissa growth, and time of eyelid opening in two inbred rate strains in the early development.
I. O. Meshkov, T. A. Alekhina, T. A. Moreva   +2 more
doaj  

Transcriptome Profiling in Rat Inbred Strains and Experimental Cross Reveals Discrepant Genetic Architecture of Genome-Wide Gene Expression

G3: Genes, Genomes, Genetics, 2016
To test the impact of genetic heterogeneity on cis- and trans-mediated mechanisms of gene expression regulation, we profiled the transcriptome of adipose tissue in 20 inbred congenic strains derived from diabetic Goto–Kakizaki (GK) rats and Brown–Norway (
Pamela J. Kaisaki, Georg W. Otto, Karène Argoud, Stephan C. Collins, Robert H. Wallis, Steven P. Wilder, Anthony C. Y. Yau, Christophe Hue, Sophie Calderari, Marie-Thérèse Bihoreau, Jean-Baptiste Cazier, Richard Mott, Dominique Gauguier   +12 more
doaj   +1 more source

Immunomodulation of salivary gland function due to cancer therapy

Oral Diseases, EarlyView.
Abstract Functional salivary glands (SG) are essential for maintaining oral health, and salivary dysfunction is a persistent major clinical challenge. Several cancer therapies also have off‐target effects leading to SG dysfunction. Recent advances highlight the role of SG immune populations in homeostasis, dysfunction and gland regeneration.
Ana C. Costa‐da‐Silva, Carlos U. Villapudua, Matthew P. Hoffman, Marit H. Aure   +3 more
wiley   +1 more source

A Major Locus Conferring Both Fusarium Crown Rot Resistance and Drought Tolerance in Barley (Hordeum vulgare L.)

Plant Breeding, EarlyView.
ABSTRACT The detrimental effects of drought on crop production are strongly influenced by interactions with other biotic and abiotic stresses, including Fusarium crown rot (FCR), a disease known to cause severe yield loss in crops experiencing drought after anthesis. This study aimed to identify loci that simultaneously confer drought tolerance and FCR
Zhouyang Su, Shang Gao, Haiyan Hu, Sergey Shabala, Meixue Zhou, Chunji Liu, Zhi Zheng   +6 more
wiley   +1 more source

Fruit Quality and Fusarium Wilt Race 2 Resistance in Cucumis melo Breeding Lines and Their F1 Hybrids

Plant Breeding, EarlyView.
ABSTRACT Cucumis melo, a sweet‐tasting fruit from the Cucurbitaceae family, is popular in global markets. While some varieties of C. melo are used for pickling or salads, melons such as cantaloupes and honeydews are consumed as a dessert. Desirable appearance, shelf life and palatability are crucial in determining a variety's success.
Cheyenne G. Cotie, Kevin M. Crosby, Kevin L. Ong, Jorge A. Da Silva   +3 more
wiley   +1 more source

Estrogen-Dependent Upregulation of Adcyap1r1 Expression in Nucleus Accumbens Is Associated With Genetic Predisposition of Sex-Specific QTL for Alcohol Consumption on Rat Chromosome 4

Frontiers in Genetics, 2018
Humans show sex differences related to alcohol use disorders (AUD). Animal model research has the potential to provide important insight into how sex differences affect alcohol consumption, particularly because female animals frequently drink more than ...
John Paul Spence, Jill L. Reiter, Bin Qiu, Hao Gu, Dawn K. Garcia, Lingling Zhang, Tamara Graves, Kent E. Williams, Paula J. Bice, Yi Zou, Zhao Lai, Weidong Yong, Tiebing Liang   +12 more
doaj   +1 more source

Controlled study of autoimmunization against liver in inbred rat strains [PDF]

Gut, 1971
By prolonged immunization of an inbred rat strain with isologous liver homogenate in Freund's complete adjuvant a low grade autoimmune ;cholangitis' with periductular fibrosis has been demonstrated. The lesion could be transferred to isogeneic animals by serial spleen cell injections and was associated with mild but variable delayed skin sensitivity to
openaire   +3 more sources

Technical considerations and review of urinary microRNAs as biomarkers for chronic kidney disease in dogs and cats

Veterinary Clinical Pathology, EarlyView.
Abstract MicroRNAs (miRNAs or miRs) are small, non‐coding RNAs that play a crucial role in gene regulation, making them potential biomarkers for various diseases. In the field of veterinary medicine, there is a growing interest in exploring the diagnostic and therapeutic potential of miRNAs in kidney diseases affecting dogs and cats.
Candice P. Chu, Mary B. Nabity
wiley   +1 more source

Systems Genetics Approaches in Rat Identify Novel Genes and Gene Networks Associated With Cardiac Conduction

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background Electrocardiographic (ECG) parameters are regarded as intermediate phenotypes of cardiac arrhythmias. Insight into the genetic underpinnings of these parameters is expected to contribute to the understanding of cardiac arrhythmia mechanisms ...
Michiel E. Adriaens, Elisabeth M. Lodder, Aida Moreno‐Moral, Jan Šilhavý, Matthias Heinig, Charlotte Glinge, Charly Belterman, Rianne Wolswinkel, Enrico Petretto, Michal Pravenec, Carol Ann Remme, Connie R. Bezzina   +11 more
doaj   +1 more source