Results 81 to 90 of about 53,463 (191)

Multi‐omics analysis identified the GmUGT88A1 gene, which coordinately regulates soybean resistance to cyst nematode and isoflavone content

Plant Biotechnology Journal, Volume 23, Issue 4, Page 1291-1307, April 2025.
Summary Soybean cyst nematode (SCN, Heterodera glycines) is a major pathogen harmful to soybean all over the world, causing huge yield loss every year. Soybean resistance to SCN is a complex quantitative trait controlled by a small number of major genes (rhg1 and Rhg4) and multiple micro‐effect genes.
Haipeng Jiang, Shuo Qu, Fang Liu, Haowen Sun, Haiyan Li, Weili Teng, Yuhang Zhan, Yongguang Li, Yingpeng Han, Xue Zhao   +9 more
wiley   +1 more source

Writing biology with mutant mice: the monstrous potential of post genomic life [PDF]

, 2011
Social scientific accounts identified in the biological grammars of early genomics a monstrous reductionism, ‘an example of brute life, the minimalist essence of things’ (Rabinow, 1996, p. 89).
Davies, GF
core  

Modulation of lignin and anthocyanin homeostasis by GTP cyclohydrolase1 in maize

Plant Biotechnology Journal, EarlyView.
Summary Maize is a key biomass resource with wide agricultural applications. Anthocyanins, potent antioxidants, offer health benefits like reducing oxidative stress. The biosynthesis of anthocyanins competes with that of lignin for shared metabolic precursors, which can lead to trade‐offs in plant growth and feed quality.
Mingyue Zhang, Xiaohan Li, Xiao Wang, Shuzhen Jiang, Junli Zhang, Mingfei Sun, Zixian Zhou, Jinxiao Zhang, Mengyao Li, Yanxiao Lv, Enlong Qi, Ziang Tian, Hongjie Zhu, Xuebin Zhang, Xiangyu Zhao, Changcheng Xu, Thomas Lübberstedt, Xiansheng Zhang, Xuerong Yang, Chao Zhou, Hongjun Liu   +20 more
wiley   +1 more source

Non‐coding RNAs in plant stress responses: molecular insights and agricultural applications

Plant Biotechnology Journal, EarlyView.
Summary Non‐coding RNAs (ncRNAs) have emerged as crucial regulators in plant responses to environmental stress, orchestrating complex networks that finetune gene expression under both abiotic and biotic challenges. To elucidate this intricate ncRNA crosstalk, this review comprehensively summarizes recent advances in understanding the mechanisms of key ...
Xiaotong Chen, Zhaohui Chen, Ryan Watts, Hong Luo   +3 more
wiley   +1 more source

Technical considerations and review of urinary microRNAs as biomarkers for chronic kidney disease in dogs and cats

Veterinary Clinical Pathology, EarlyView.
Abstract MicroRNAs (miRNAs or miRs) are small, non‐coding RNAs that play a crucial role in gene regulation, making them potential biomarkers for various diseases. In the field of veterinary medicine, there is a growing interest in exploring the diagnostic and therapeutic potential of miRNAs in kidney diseases affecting dogs and cats.
Candice P. Chu, Mary B. Nabity
wiley   +1 more source

Mitochondrial haplotype and sex modulate responses to endurance exercise training

The Journal of Physiology, EarlyView.
Abstract figure legend Using OKC‐HETB/W rats we demonstrate that mitochondrial haplotype influences training responses of endurance exercise. Overall OKC‐HETW rats showed greater responses than OKC‐HETB in exercise tolerance, mitochondrial bioenergetics, mitochondrial DNA (mtDNA) mutation frequencies and motor co‐ordination.
Bumsoo Ahn, Tianhao Wei, Ryan Pettit‐Mee, Eunyoung Kim, Robert V. Musci, Jonathan Wanagat, Hoang Van M. Nguyen, Arlan Richardson, Hyunyoung Kim   +8 more
wiley   +1 more source

Creation of a Computational Pipeline to Extract Genes from Quantitative Trait Loci for Diabetes and Obesity [PDF]

, 2015
Type 2 Diabetes is a disease of relative insulin deficiency resulting from a combination of insulin resistance and decreased beta-cell function. Over the past several years, over 60 genes have been identified for Type 2 Diabetes in human genome-wide ...
Fox, Joseph
core   +1 more source

14‐3‐3 proteins: Regulators of cardiac excitation–contraction coupling and stress responses

The Journal of Physiology, EarlyView.
Abstract figure legend 14‐3‐3 protein interactions in cardiac regulation. Schematic representation of 14‐3‐3 binding partners in excitation–contraction coupling, transcriptional regulation/development and stress response pathways. Asterisks indicate targets where the exact 14‐3‐3 binding site is unknown.
Heather C. Spooner, Rose E. Dixon
wiley   +1 more source

How Do Individually Ventilated Cages Affect the Welfare of Male BALB/c Mice? Comprehensive Assessment of Behavior, Metabolism, and Responses to Acute Painful Stimuli

Brain and Behavior, Volume 15, Issue 6, June 2025.
IVC housing conditions cause significant changes in behavioral patterns, metabolism, and nociceptive responses in mice. ABSTRACT Introduction Housing conditions, which have a major impact on the welfare of laboratory animals, are an important issue in experimental research.
Aslı Çelik, Cemre Ural, Hatice Efsun Kolatan, Pembe Keskinoğlu, Mehmet Ateş, Zahide Çavdar, Osman Yılmaz, Mehmet Ensari Güneli   +7 more
wiley   +1 more source

Elucidation of Mechanism of Action in Drug Invention: Using Stable Isotope Tracers to Unravel Biochemical Kinetics

Pharmacology Research &Perspectives, Volume 13, Issue 3, June 2025.
ABSTRACT The invention of a therapeutic begins by characterizing features that differentiate healthy versus diseased states; this often presents as changes in the concentration of an analyte. Examples include elevated blood glucose in diabetes, high cholesterol in heart disease, and protein aggregation in neurodegeneration.
Rebecca A. Kohnz, Dan Zhou, Bin Lou, Huifang Yao, David McKenney, Dhiraj Dokwal, Ruth Villanueva, Heidi Kocalis, Jeanine E. Ballard, Jennifer Piesvaux, Stephen F. Previs   +10 more
wiley   +1 more source