Results 81 to 90 of about 130,261 (276)

Enhancer Rewiring Orchestrates Inflammation and Loss of Cell Identity During Muscle Stem Cell Aging

Aging Cell, EarlyView.
A comprehensive multi‐omic profiling of murine muscle stem cells across three ages and both sexes reveals extensive enhancer and 3D genome rewiring, concomitant with increased inflammation, lineage drift, loss of quiescence, and reduced myogenic potential.
Changyou Shi, Na Yang, Evelyn Pizano, Lin Wang, James R. Occean, Chang‐Yi Cui, Ling Liu, Christopher Dunn, Frimpong Boadu, Qiong Meng, Nirad Banskota, Jen‐Hao Yang, Jinshui Fan, Supriyo De, Jianlin Cheng, Thomas A. Rando, Vittorio Sartorelli, Payel Sen   +17 more
wiley   +1 more source

Genetical genomic determinants of alcohol consumption in rats and humans

BMC Biology, 2009
Background We have used a genetical genomic approach, in conjunction with phenotypic analysis of alcohol consumption, to identify candidate genes that predispose to varying levels of alcohol intake by HXB/BXH recombinant inbred rat strains.
Mangion Jonathan, Pravenec Michal, Hübner Norbert, Heinig Matthias, Bell Richard L, Kechris Katerina, Richardson Heather N, Koob George, Goldman David, Hodgkinson Colin, Flodman Pam, Printz Morton, Saba Laura, Tabakoff Boris, Legault Lucie, Dongier Maurice, Conigrave Katherine M, Whitfield John B, Saunders John, Grant Bridget, Hoffman Paula L   +20 more
doaj   +1 more source

Murine models of renal disease: Possibilities and problems in studies using mutant mice [PDF]

, 2000
The elucidation of the pathogenesis of human renal disease at the molecular level has been facilitated by the growing field of gene targeting and the development of mouse strains with single-gene deletions - the `knock-out' mice. Experimental nephrology,
Anders, Hans-Joachim, Schlöndorff, Detlef   +1 more
core   +1 more source

Body surface temperatures as biomarkers of physiological environmental adaptation in wild birds and mammals

Biological Reviews, EarlyView.
ABSTRACT The ability of individuals to cope with their environment, and therefore the likelihood that they survive and pass on their genes (i.e. fitness), is largely determined by physiological state. Tracking physiological state in wild animals, however, is challenging.
Paul Jerem, L. Michael Romero
wiley   +1 more source

Fischer 344 and Lewis rat strains as a model of genetic vulnerability to drug addiction

Frontiers in Neuroscience, 2016
Today it is well acknowledged that both nature and nurture play important roles in the genesis of psychopathologies, including drug addiction. Increasing evidence suggests that genetic factors contribute for at least 40-60 % of the variation in liability
Cristina eCadoni
doaj   +1 more source

Neuroimaging Evidence of Major Morpho-Anatomical and Functional Abnormalities in the BTBR T+TF/J Mouse Model of Autism [PDF]

, 2013
BTBR T+tf/J (BTBR) mice display prominent behavioural deficits analogous to the defining symptoms of autism, a feature that has prompted a widespread use of the model in preclinical autism research.
A Gozzi, A Gozzi, A Gozzi, A Gozzi, A Gozzi, AA Turk, AC Stanfield, AE Dorr, Alberto Galbusera, Alessandro Gozzi, Allan V. Kalueff, Angelo Bifone, AY Hardan, AY Hardan, B Avants, BA Babineau, BB Avants, BB Avants, BB Avants, BU Meye, D Badaruddin, D Wahlsten, D Wahlsten, E Anagnostou, F Tovar-Moll, G Zaharchuk, H Ito, H Utsunomiya, J Ashburner, J Ellegood, JL Silverman, JL Silverman, JL Silverman, JL Whitwell, JM Mountz, JP Lerch, JP Lerch, KL Hyde, L Ferrari, L Ferrari, LK Paul, LK Paul, Luca Dodero, M Magnuson, M Sasaki, M Wohr, M Yang, M Yang, M Yang, M Zilbovicius, MA Just, Maria Luisa Scattoni, Mario Damiano, ME Vissers, ML Scattoni, ML Senjem, MM Haznedar, MM Haznedar, MS George, N Boddaert, N Hadjikhani, O Devinsky, R Adolphs, R Via E, RG Gonzalez, RJ Zatorre, S Mori, S Schobel, S Shen, SM Smith, Sotirios A. Tsaftsaris, SR Das, SS Moy, SS Moy, T Ohnishi, T Ren, TW Frazier, VJ Bolivar, WS Brown   +78 more
core   +3 more sources

Shear Stress Is Differentially Regulated Among Inbred Rat Strains [PDF]

Circulation Research, 2003
An important compensatory response to atherosclerosis is vascular remodeling, with maintenance of vessel lumen diameter and shear stress. Both hemodynamic and environmental factors contribute to vascular remodeling and shear stress regulation, and the process is probably also influenced by genetic factors.
Jamila, Ibrahim, Jody K, Miyashiro, Bradford C, Berk   +2 more
openaire   +2 more sources

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, EarlyView.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

Social learning promotes nicotine self-administration by facilitating the extinction of conditioned aversion in isogenic strains of rats

Scientific Reports, 2017
Both social environment and genetic factors are critical for smoking initiation and nicotine addiction. We reported that rats developed conditioned flavor (i.e., taste and odor) aversion to intravenously self-administered (IVSA) nicotine, and that social
Wenyan Han, Tengfei Wang, Hao Chen
doaj   +1 more source

Self-Confirmation and Ascertainment of the Candidate Genomic Regions of Complex Trait Loci - A None-Experimental Solution.

PLoS ONE, 2016
Over the past half century, thousands of quantitative trait loci (QTL) have been identified by using animal models and plant populations. However, the none-reliability and imprecision of the genomic regions of these loci have remained the major hurdle ...
Lishi Wang, Yan Jiao, Yongjun Wang, Mengchen Zhang, Weikuan Gu   +4 more
doaj   +1 more source