Results 131 to 140 of about 159,497 (267)

To Study the Effect of Nilotinib, a Tyrosine Kinase Inhibitor, on Learning and Memory and Its Comparison with Nitric Oxide Synthase Inhibitor in an Animal Model of Alzheimer's Disease. [PDF]

Ann Neurosci
Kumar A, Fatima N, Kumar P, Nath R, Sachan AK, Dixit RK, Pal R.   +6 more
europepmc   +1 more source

Natural Polysaccharides for Rheumatoid Arthritis Therapy: Mechanism, Drug Delivery and Clinical Application

Phytotherapy Research, EarlyView.
Schematic overview of the experimental models, therapeutic mechanisms, drug delivery systems, and clinical potential of natural polysaccharides in rheumatoid arthritis. ABSTRACT Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized primarily by chronic synovitis.
Luxin Li, Junnan Li, Guangzhi Li, Lili Huang, Tiantian Wen, Yanying Li, Yan Sun, Zhenqiang Liu, Qingshan Chen, Lili Zhang, Tiangang Lu, Ruiyan Wu, Haixue Kuang, Xiaochi Ma, Yan Liu   +14 more
wiley   +1 more source

Anticonvulsant potential of tolfenamic acid in pentylenetetrazol-induced acute symptomatic seizures in male wistar rats. [PDF]

J Physiol Sci
Hakimi Naeini S, Azizi V, Hosseini A.
europepmc   +1 more source

Herbal Therapeutics in Osteoporosis: Mechanisms, Evidence, and Translational Potential

Phytotherapy Research, EarlyView.
Schematic overview of bone remodeling dysregulation in osteoporosis and the multi‐target protective role of herbal therapeutics. ABSTRACT Osteoporosis is a chronic bone disease marked by reduced density and increased fracture risk. Current treatments face limitations in safety, efficacy, and long‐term adherence, prompting interest in alternative ...
Elnaz Vafadar Moradi, Sina Vossoughinia, Zahra Yazdanpanah, Hossein Sobhani, Jalileh Jalali, Mahboobeh Ghasemzadeh Rahbardar   +5 more
wiley   +1 more source

Toll‐Like Receptor 4 Signaling in Natural N‐Acylethanolamines and Derivative NAE‐Like Compounds: Mechanisms and Implications for Neuroimmune and Inflammatory Processes in a Systematic Search Approach

Phytotherapy Research, EarlyView.
ABSTRACT N‐acylethanolamines (NAEs) are endogenous fatty acid amides structurally related to the endocannabinoid anandamide and function as bioactive lipid mediators with broad regulatory roles in inflammation and neuroinflammation. Among pattern‐recognition receptors, Toll‐like receptor 4 (TLR4) occupies a central position in innate immune ...
Damiana Scuteri, Francesca Guida, Giacinto Bagetta, Sabatino Maione, Maria Tiziana Corasaniti, Morena Zusso   +5 more
wiley   +1 more source

Chronic High-Fat Diet Downregulates M3 Muscarinic and β1-Adrenergic Receptor mRNA Expression and Alters Submandibular Gland Histology in Wistar Rats. [PDF]

Diabetes Metab Syndr Obes
Fitria D, Veronica F, Radhiyanti PT, Sari KI, Goenawan H.   +4 more
europepmc   +1 more source

Disrupted joint clock is associated with rhythmic expression of bone destruction factors in collagen‐induced arthritis

Rheumatology &Autoimmunity, EarlyView.
Schematic Summary of Circadian Dysregulation in Arthritic Joints. This graphical abstract illustrates the key circadian disruptions observed in the collagen‑induced arthritis (CIA) model. The diagram depicts three main findings: (1) Nocturnal elevations in pro‑inflammatory cytokines (TNF‑α, IL‑6, IL‑17, IL‑1β, MIF) and bone‑destructive factors (DKK‑1 ...
Xiaogang Zhang, Mingming Zhang, Zhiqiang Wang, Jie Bai, Xing Feng, Yajing Wang, Zhenbin Li, Dongbao Zhao   +7 more
wiley   +1 more source

Gestational Low Protein Diet Increases the Susceptibility to N-Bis(2-Hydroxypropyl)nitrosamine-Induced Lung Tumors in Female Wistar Rats. [PDF]

Environ Mol Mutagen
Ferreira VCMP, Carvalho VH, Boer PA, Barbisan LF.   +3 more
europepmc   +1 more source

Reverse Micelles: The Gateway for Oral (Poly)Peptide Delivery

Small, EarlyView.
RM achieve superior oral peptide delivery through high loading capacity, strong lipophilicity, and a low‐hydration microenvironment that protects against enzymatic degradation. Meanwhile, dRM provides favorable permeation‐enhancing interactions and a consistent safety profile, collectively driving enhanced oral performance.
Marlene Ramona Schmidt, Melanie Lena Ebert, Andreas Bernkop‐Schnürch   +2 more
wiley   +1 more source

A thermally processed cafeteria diet reproducibly mimics early metabolic syndrome through obesity, insulin resistance, and inflammatory activation in Wistar rats. [PDF]

Biosci Rep
Ribeiro SB, de Oliveira Melo RC, de Carvalho LVS, da Silva Júnior AA, de Araújo Júnior RF, da Silva AS, de Paiva GM, Garcia VB, de Araújo Morais AH, Aguiar AJFC, de Medeiros CACX, de Morais M, Dos Santos BRM, Mokwa RL, de Souza Junior FC, de Souza Lima MCJ, Soares CD, de Araújo AA.   +17 more
europepmc   +1 more source