Results 131 to 140 of about 852,599 (306)

Glycemic index, nutrient density, and promotion of aberrant crypt foci in rat colon [PDF]

open access: yes, 1998
We speculated that a diet with a high glycemic index (GI), or a diet with a low nutrient density (nutrient-to-calorie ratio), would enhance colon carcinogenesis, presuma-bly via increased insulin resistance.
Peiffer, Ginette   +2 more
core  

Unilateral thyroid dysgenesis in Wistar/ST rats.

open access: yes, 2019
(A) Gross features of the thyroid glands in Wistar/ST rats. In this case, the left lobe and isthmus of the thyroid gland is absent, and the parathyroid glands are localized alongside the trachea (arrowhead). TC: thyroid cartilage, TG: thyroid glands, Tr:
Hideki Hattori (7325933)   +8 more
core   +1 more source

Protective Role of Polydatin Against Vancomycin‐Induced Lung Toxicity via Oxidative Stress, Inflammation, Endoplasmic Reticulum Stress, Apoptosis, and Ferroptosis Pathways

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT This study aimed to evaluate whether polydatin (Poly) could eliminate the harmful effects of vancomycin (VCM) on the lungs of rats. Rats were administered VCM (200 mg/kg) and Poly (50 mg/kg), both separately and in combination, for a duration of 7 days.
Serpil Aygörmez   +6 more
wiley   +1 more source

The Effects of Angiotensin Receptor Neprilysin Inhibitor on Endoplasmic Reticulum Stress in Doxorubicin‐Mediated Cardiomyopathy‐Associated Heart Failure Model in Rats

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT One of the most serious complications associated with the use of the chemotherapeutic agent doxorubicin (DOX) is cardiomyopathy. Although cardioprotective drugs such as angiotensin receptor‐neprilysin inhibitors (ARNI) are used to prevent cardiomyopathy in DOX patients, no studies have reported the relationship between ARNI and endoplasmic ...
Mert Unvan   +3 more
wiley   +1 more source

Lipidemic effects of common edible oils and risk of atherosclerosis in diabetic Wistar rats

open access: yesARYA Atherosclerosis, 2017
BACKGROUND: Diabetic state potentiates atherosclerosis and the type of edible oil consumed by the individual may affect this further. This study aimed to determine if the common edible oils in Nigeria have any effects on the lipid profiles and arteries ...
Olulola Olutoyin Oladapo   +3 more
doaj  

Epirubicin Alters Pancreatic Autophagy and Insulin Synthesis Through a Zinc‐Dependent Mechanism

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT Epirubicin (EPI) can cause metabolic side effects, including chemotherapy‐related diabetes, partly through oxidative stress that disrupts zinc (Zn) homeostasis and impairs autophagy. This study investigated the effects of EPI on Zn regulation and autophagy in the pancreas, as well as the modulatory role of N‐acetylcysteine (NAC). Rats received
Ebru Afşar, Işıl Eranıl
wiley   +1 more source

Diferentes respostas reforçadoras e locomotoras induzidas pela ativação de endocanabinóide em ratos adolescentes e adultos das linhagens Wistar e Shr [PDF]

open access: yes, 2007
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Farmacologia.Várias evidências apontam para a adolescência como um período crítico para o início de uma ampla escala de ...
Pandolfo, Pablo
core  

Toxic Effects of Bisphenol A and Its Analogs on Ovarian Structure and Function: A Narrative Review of Ovary‐Focused Studies

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) is a widely used industrial chemical found in polycarbonate plastics and epoxy resins and is recognized for its endocrine‐disrupting properties. Human exposure is common due to its presence in food packaging and everyday products. As BPA use has been restricted, structurally similar compounds such as BPS, BPB, BPAF, and BADGE
Nurbanu Zengin   +4 more
wiley   +1 more source

Reduced hippocampal GABAergic function in Wistar audiogenic rats

open access: yesBrazilian Journal of Medical and Biological Research, 2011
Epilepsy is a neurological disorder associated with excitatory and inhibitory imbalance within the underlying neural network. This study evaluated inhibitory γ-amino-butyric acid (GABA)ergic modulation in the CA1 region of the hippocampus of male ...
L.E. Drumond   +5 more
doaj   +2 more sources

Response to letter by Yao (Differences in the evolution of the ischemic penumbra in stroke-prone spontaneously hypertensive and Wistar-Kyoto rats) [PDF]

open access: yes, 2010
Graham, D.   +11 more
core   +1 more source

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