Results 91 to 100 of about 1,831,838 (319)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Influence of diabetes on the character of changes of resorption and repair processes in the parodontium and mandibular tissues after tooth extraction

Patologìâ
Today, diabetes mellitus (DM) represents a problem on which the attention of endocrinologists, general practitioners, and dentists is focused. Early pathological changes, which manifest themselves in the oral cavity, determine the relevance and social ...
A. V. Abramov, K. S. Hanchev
doaj   +1 more source

Disturbance of nitric oxide synthase constitutive isoforms expression as a pathogenetic factor of complications development after tooth extraction in experimental diabetes mellitus

Patologìâ, 2018
The role of constitutive NOS isoforms (endothelial and neuronal) in pathogenesis of complications development and repair processes disturbances in periodontium after tooth extraction in experimental diabetes mellitus is not studied completely. The aim
K. S. Hanchev, A. V. Abramov
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Genistein affects the morphology of pituitary ACTH cells and decreases circulating levels of ACTH and corticosterone in middle-aged male rats

Biological Research, 2009
The soybean phytoestrogen, genistein, is increasingly consumed as an alternative therapeutic for age-related diseases, namely cardiovascular conditions, cancer and osteoporosis.
VLADIMIR Z AJDŽANOVI, BRANKA T ŠOŠI-JURJEVI, BRANKO R FILIPÓVI, SVETLANA L TRIFUNOVI, DEJAN D BRKIC, MILKA I SEKULI, VERICA LJ MILOSEVI   +6 more
doaj  

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Effect Of Spray-dried Ethanolic Extract of Andrographis Paniculata (Burm. F.) Nees On Streptozotocin-induced Diabetic Female Rats. [PDF]

, 2006
The objective of this study was to evaluate the effect of commercially prepared spray-dried ethanolic extract ol Andrographis paniculafa (AP) on streptozotocin (STZ)-induced diabetic female rats.
Amrah, S. S., Hasenan, N., Hasnan, J., Ghan, K. L., Mohsins, S. J., Syahrin, A. S., Lim, B.Y.   +6 more
core  

The effect of eight weeks of intense interval training combined with bee pollen consumption on the levels of serotonin, dopamine, and PGC-1α proteins in the hippocampus of rats exposed to cadmium [PDF]

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām
Introduction:  Neurotransmitters and PGC1α enhance neurological disorders, regulate mitochondrial function, and oxidative stress in the central nervous system, while toxic cadmium damages nervous system structures.
Aref Heydari, Vahid Valipour Dehnou, Firuz Sharafi Deharham, Mehdi Roozbahani   +3 more
doaj  

Impact of Teriparatide Acetate on Caspase-9 Gene Expression in Relation to Histological and Tunnel Assay of Apoptosis in Rat Kidneys and Livers [PDF]

Journal of Applied Veterinary Sciences
The study aimed to evaluate the effects of Teriparatide on liver and kidney tissues in rats and to examine the relationship between these effects and the gene expression of caspase-9 focusing on the mechanism of apoptosis. The experiment included 20 male
Saif Al-Jammas, Ghada Taqa, Ayad AL_Saraj   +2 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source