Results 121 to 130 of about 3,497,773 (355)

LEW.1WR1 Rats Develop Autoimmune Diabetes Spontaneously and in Response to Environmental Perturbation [PDF]

, 2005
John P. Mordes, Dennis L. Guberski, Jean Leif, Bruce A. Woda, Joan F. Flanagan, Dale L. Greiner, Edward Kislauskis, Rebecca S. Tirabassi   +7 more
openalex   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Classification of Epileptic Seizures by Simple Machine Learning Techniques: Application to Animals’ Electroencephalography Signals

IEEE Access
Detection and prediction of the onset of seizures are among the most challenging problems in epilepsy diagnostics and treatment. Small electronic devices capable of doing that will improve the quality of life for epilepsy patients while also open new ...
Illia Pidvalnyi, Anna Kostenko, Oleksandr Sudakov, Dmytro Isaev, Oleksandr Maximyuk, Oleg Krishtal, Olena Iegorova, Ievgen Kabin, Zoya Dyka, Steffen Ortmann, Peter Langendorfer   +10 more
doaj   +1 more source

A Novel Chemically Modified Curcumin “Normalizes” Wound-Healing in Rats with Experimentally Induced Type I Diabetes: Initial Studies [PDF]

, 2016
Yazhou Zhang, Steve A. McClain, Hsi‐Ming Lee, Muna S. Elburki, Huiwen Yu, Ying Gu, Yu Zhang, Mark S. Wolff, Francis Johnson, Lorne M. Golub   +9 more
openalex   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Nitric oxide donation lowers blood pressure in adrenocorticotrophic hormone-induced hypertensive rats.

, 2004
Adrenocorticotrophic hormone (ACTH) elevates systolic blood pressure (SBP) and lowers plasma reactive nitrogen intermediates in rats. We assessed the ability of NO donation from isosorbide dinitrate (ISDN) to prevent or reverse the hypertension caused by
Andrews, Miles C, McKenzie, Katja US, Schyvens, Christopher G, Whitworth, Judith A, Zhang, Yi   +4 more
core   +1 more source

Dietary Choline Deprivation Exacerbates Kidney Injury in Streptozotocin-Induced Diabetes in Adult Rats

Diabetology
Background: Choline (Ch) deprivation causes kidney injury and dysfunction, and diabetic nephropathy is also known to be a complication of diabetes; thus, this interplay could potentially aggravate diabetic kidney disease.
Ahmed W. Al-Humadi, Carel W. le Roux, Neil G. Docherty, Werd Al-Najim, Martin Tze Wah Kueh, Andreas C. Lazaris, Charis Liapi   +6 more
doaj   +1 more source

Melatonin Attenuates Pulmonary Hypertension in Chronically Hypoxic Rats [PDF]

, 2017
Ming Yow Hung, Hang Mee Yeung, Chi Lau, Angela MS Poon, George L. Tipoe, M. K. Fung   +5 more
openalex   +1 more source

Pinostrobin alleviates chronic restraint stress‑induced cognitive impairment by modulating oxidative stress and the function of astrocytes in the hippocampus of rats

, 2023
Sitthisak Thongrong, Serm Surapinit, Tichanon Promsrisuk, Jinatta Jittiwat, Ratchaniporn Kongsui   +4 more
openalex   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source