Results 71 to 80 of about 798,166 (289)

A New EGFR Inhibitor from Ficus benghalensis Exerted Potential Anti-Inflammatory Activity via Akt/PI3K Pathway Inhibition

Current Issues in Molecular Biology, 2022
Inflammation is a critical defensive mechanism mainly arising due to the production of prostaglandins via cyclooxygenase enzymes. This study aimed to examine the anti-inflammatory activity of fatty acid glucoside (FAG), which is isolated from Ficus ...
Rania Alaaeldin, Heba Ali Hassan, Islam M. Abdel-Rahman, Reham H. Mohyeldin, Nancy Youssef, Ahmed E. Allam, Sayed F. Abdelwahab, Qing-Li Zhao, Moustafa Fathy   +8 more
doaj   +1 more source

Dual‐Targeting Biomimetic Nanozymes Loaded Microneedle Patch Promotes Scarless Wound Healing Through Anti‐Inflammatory and Anti‐Fibrotic Effects

Advanced Science, EarlyView.
This study developed a dual‐targeting biomimetic nanozyme hybrid system (Cu‐CeO2@ABs‐FTP) and integrated it with HAMA hydrogel to fabricate a microneedle patch (CAF@MN). The patch promotes fibroblast‐mediated wound repair, targets macrophages to induce M2 polarization, and targets myofibroblasts to exert anti‐fibrotic effects, thereby enabling rapid ...
Hongyi Zhang, Jinwei Li, Shan Hua, Shengming Wu, Chenlong He, Yuan Zhu, Ming Yin, Han Zhou, Huawei Liu, Chika Hasegawa, Jun Lyu, Keyue Xiao, Hua Jiang, Yilong Wang, Yuxin Qian   +14 more
wiley   +1 more source

Disease‐Stage Synchronized Nanozyme Therapy for Polymicrobial Sepsis through Adaptive Catalytic and Immune Reprogramming

Advanced Science, EarlyView.
A disease‐stage synchronized nanozyme platform is developed to treat polymicrobial sepsis by adapting its functions to changing infection environments. The system eliminates multidrug‐resistant bacteria during early infection while reducing inflammation and restoring immune balance during recovery, providing an integrated strategy for infection control
Anlai Zou, Xiaoxue Zhu, Runhan Zhu, Chengchu Xue, Qinyu Zhang, Mengke Li, Ting Yu, Yuzhen Gao, Zhi Ruan, Ying Fu, Yunlei Xianyu, Jun Zhang   +11 more
wiley   +1 more source

Nanoscale Bioactive Glass Activates Osteoclastic Differentiation of RAW 264.7 Cells [PDF]

Nanomedicine, 2016
There is limited knowledge regarding differentiation of osteoclasts in the presence of nanoscale bioactive glass (nBG). This investigation examined increasing concentrations of 45S5 nBG and their influence on osteoclast differentiation.Different concentrations of 45S5 nBG were cultured up to 14 days with the murine RAW264.7 cell line and human primary ...
Detsch, Rainer, Rübner, Matthias, Strissel, Pamela L, Mohn, Dirk, Strasser, Erwin, Stark, Wendelin J, Strick, Reiner, Boccaccini, Aldo R   +7 more
openaire   +3 more sources

Raw 264.7 cells bind and phagocytose C. difficile spores.

, 2013
A,B,C,D,E,F) SEM of Raw 264.7 cells infected with C. difficile spores under aerobic conditions. Note the active phagocytosis of the spores by Raw 264.7 cells in both panels. White arrows denote coiling phagocytosis.
Glenda Cofre-Araneda (310434), Mahfuzur R. Sarker (310438), Marjorie Pizarro-Guajardo (310436), Christian Brito-Silva (310435), Daniel Paredes-Sabja (310433)   +4 more
core   +1 more source

Engineered Cyanobacteria‐Hydrogel Microecological System for Oxygen Reprogramming Synergizes Immunomodulation With Anabolism in Osteoarthritis Therapy

Advanced Science, EarlyView.
An injectable cyanobacteria‐laden hydrogel enables light‐dependent oxygen metabolism engineering for osteoarthritis therapy. Photosynthetic oxygen release under red light irradiation suppresses synovial inflammation via HIF‐1α inhibition and M2 macrophage polarization, while respiratory oxygen consumption in darkness stabilizes chondrocyte HIF‐1α to ...
Lerong Yang, Chong Shen, Hongjun Huang, Siyi Liu, Zeyu Huang, Licheng Xi, Huan Cao, Li Zheng, Zainen Qin   +8 more
wiley   +1 more source

Immunomodulatory effects of Substance P in the M1- to M2-like phenotype conversion of RAW 264.7 cells.

, 2016
Immunomodulatory effects of Substance P in the M1- to M2-like phenotype conversion of RAW 264.7 cells.
Nadia Lampiasi (420771), Giovanna Montana (3372680)   +1 more
core   +1 more source

Effects of quinoline-arylamidine hybrids on LPS-induced inflammation in RAW 264.7 cells [PDF]

, 2020
Background and purpose: Inflammation is a common pathogenesis in infection, injury, cancer, and many chronic diseases. Macrophages are among the main cells involved in generation of inflammation.
Jukić, Marijana, Glavaš-Obrovac, Ljubica, Krstulović, Luka, Bajić, Miro, Periš, Antonio, Antonio Peris   +5 more
core   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice

Hepatology, EarlyView., 2022
Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim, Jaewoong Lee, Hyun Joo Shin, Eun Ae Jeong, Hye Min Jang, Yu Jeong Ahn, Hyeong Seok An, Jong Youl Lee, Meong Cheol Shin, Soo Kyoung Kim, Won Gi Yoo, Won Ho Kim, Gu Seob Roh   +12 more
wiley   +1 more source