Results 81 to 90 of about 798,166 (289)

Toxicity of PAO1 toward RAW 264.7 cells.

, 2013
A) RAW 264.7 cells were exposed to PAO1 in the presence of different kinase inhibitors: SP600125 (for JNK, 10 mg/ml), U0126 (for MEK, 10 mg/ml) and BMS345541 (for IKK, 10 mg/ml). MTT assays quantitated cell viability after 1 day.
Alan M. Tartakoff (276669), Sanhita Roy (276667), Tracey Bonfield (276668)   +2 more
core   +1 more source

Natural‐Inspired Engineered Microalgae With Selenium Enrichment Enabled Potent Anti‐Tumor Immunity

Advanced Science, EarlyView.
Se‐Ssp was engineered as a potent immunomodulator for activating innate immunity via the TLR and cGAS‐STING pathways, therefore converting “cold” tumors into “hot” tumors to achieve high efficacy and long‐term therapeutic outcomes. ABSTRACT Immunotherapy has shed light on clinical oncology for several decades.
Yuqi Yang, Xiaowei Cai, Xiaoyan Zhong, Tian Qiu, Qinwei Lu, Jiahao Qin, Fei Gong, Yecheng Huang, Chenyu Jiang, Youdong Chen, Yuan Cheng, Liang Cheng   +11 more
wiley   +1 more source

Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis

Hepatology, EarlyView., 2022
EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu, Xiude Fan, Megan R. McMullen, Tatsunori Miyata, Adam Kim, Vai Pathak, Jianguo Wu, Le Z. Day, Josiah E. Hardesty, Nicole Welch, Jaividhya Dasarathy, Daniela S. Allende, Arthur J. McCullough, Jon M. Jacobs, Daniel M. Rotroff, Srinivasan Dasarathy, Laura E. Nagy   +16 more
wiley   +1 more source

Shikonin Directly Inhibits Nitric Oxide Synthases: Possible Targets That Affect Thoracic Aorta Relaxation Response and Nitric Oxide Release From RAW 264.7 Macrophages

Journal of Pharmacological Sciences, 2010
Recently, an isomeric mixture of herbal anti-inflammatory naphthoquinones shikonin and alkannin, and their derivatives, have been found to impair cellular responses involving nitric oxide (NO) and NO synthesis, like the acetylcholine-induced relaxation ...
Lucia S. Yoshida, Tomie Kawada, Kaoru Irie, Yasukatsu Yuda, Toshiyuki Himi, Fumihiko Ikemoto, Hiromi Takano-Ohmuro   +6 more
doaj   +1 more source

Lipopolysaccharide-induced innate immune responses are exacerbated by Prohibitin 1 deficiency and mitigated by S-adenosylmethionine in murine macrophages.

PLoS ONE, 2020
Prohibitin 1 (Phb1) is a pleiotropic protein with multiple functions in mammalian cells including cell cycle regulation and mitochondrial protein stabilization.
Soohan Jung, Jaehee Park, Kwang Suk Ko
doaj   +1 more source

Matrix effect in Raw 264.7, RBL-2H3 and Jurkat T-cell extracts.

, 2015
aEach point is based on five replicates.Matrix effect in Raw 264.7, RBL-2H3 and Jurkat T-cell extracts.
Adele Cutignano (159219), Daniela Corda (259902), Stefania Mariggiò (259878), Angelo Fontana (404567), Laura Grauso (720463)   +4 more
core   +1 more source

Reversing Macrophage Immunometabolic Dysfunction in Prolonged Infections Via a Glutaminolysis‐Fueled Restoration‐Based Hierarchically Selective Therapeutic System

Advanced Science, EarlyView.
A hierarchically selective immunotherapeutic nanoplatform, mGls@HEV‐MTP, selectively restores macrophage immunocompetence through GLS1‐mediated restoration of glutaminolysis‐fueled anaplerosis. Concurrently, it renders Staphylococcus aureus (S. aureus) more readily recognizable to the metabolically reprogrammed macrophages, thereby facilitating ...
Weinan Yang, Zihao An, Honglu Cai, Congsun Li, Jiaxuan Zou, Wushi Cui, Wentao Chen, Tao Zhang, Shicheng Wang, Zizhan Su, Jian Xiao, Tao Sun, Bin Hu, Min Cheng, Zhongru Gou, Jianbin Xu, An Liu, Haobo Wu   +17 more
wiley   +1 more source

HPLC-PDA Analysis and Anti-inflammatory Effects of Mori Cortex Radicis

Natural Product Communications, 2013
Mori Cortex Radicis (MCR, Moraceae) is used traditionally in the treatment of jaundice, hematemesis, edema, and pollakisuria in Korea. In this study, the anti-inflammatory effects of MCR extract were investigated using RAW 264.7 cells.
Chang-Seob Seo, Hye-Sun Lim, Soo-Jin Jeong, Hyekyung Ha, Hyeun-Kyoo Shin   +4 more
doaj   +1 more source

Effect of morin on MSU crystal-induced production of pro-inflammatory meditors in RAW 264.7 macrophage cells.

, 2016
(a) The levels of (i) PGE2 and NO were measured in the culture medium. (b) The level of (i) TNF-α, (ii) IL-1β, (iii) IL-6, (iv) MCP-1, (v) VEGF and PGE2 in the culture medium was measured by its respective ELISA kits.
Sowmiya Kalaiselvan (841575), Chitra Dhanasekar (841574), Mahaboobkhan Rasool (841576)   +2 more
core   +1 more source

Quantitative Visualization of Intracellular Nanometabolism Using Peak‐Shifted Dual‐State Emissive FRET Nanoprobes

Advanced Science, EarlyView.
This study reveals the long‐elusive intracellular dissolution mechanism of carrier‐free nanomedicines. By utilizing peak‐shifted dual‐state emissive FRET nanoprobes (PDFNPs) that undergo a distinct ratiometric fluorescence peak shift upon disassembly, we achieve real‐time, quantitative tracking of dissolution kinetics in live cells.
Farsai Taemaitree, Jinwoo Sung, Yutaro Miki, Ryuju Suzuki, Yoshitaka Koseki, Kunikazu Ishii, Minsang Kim, Keita Tanita, Kota Sato, Toru Nakazawa, Satoshi Katsube, Daisuke Unabara, Tasuku Hamaguchi, Keisuke Kawakami, Koji Yonekura, Akihide Hibara, Atsushi Wakamiya, Hiroshi Uji‐I, Hitoshi Kasai   +18 more
wiley   +1 more source