Results 91 to 100 of about 5,986,284 (284)

Reversing Macrophage Immunometabolic Dysfunction in Prolonged Infections Via a Glutaminolysis‐Fueled Restoration‐Based Hierarchically Selective Therapeutic System

Advanced Science, EarlyView.
A hierarchically selective immunotherapeutic nanoplatform, mGls@HEV‐MTP, selectively restores macrophage immunocompetence through GLS1‐mediated restoration of glutaminolysis‐fueled anaplerosis. Concurrently, it renders Staphylococcus aureus (S. aureus) more readily recognizable to the metabolically reprogrammed macrophages, thereby facilitating ...
Weinan Yang, Zihao An, Honglu Cai, Congsun Li, Jiaxuan Zou, Wushi Cui, Wentao Chen, Tao Zhang, Shicheng Wang, Zizhan Su, Jian Xiao, Tao Sun, Bin Hu, Min Cheng, Zhongru Gou, Jianbin Xu, An Liu, Haobo Wu   +17 more
wiley   +1 more source

Cadmium activates NLRP3 inflammasome-mediated pyroptosis in murine macrophage cell line RAW 264.7

, 2022
Introduction: Cadmium (Cd) is an environmental toxin that affects the kidney, liver and lungs. Its effect on innate immunity is not well known. Methods: RAW 264.7 macrophage cells were treated with different concentrations of CdCl₂ (5, 10, 15 μM) for ...
Robinson, Caila
core  

Quantitative Visualization of Intracellular Nanometabolism Using Peak‐Shifted Dual‐State Emissive FRET Nanoprobes

Advanced Science, EarlyView.
This study reveals the long‐elusive intracellular dissolution mechanism of carrier‐free nanomedicines. By utilizing peak‐shifted dual‐state emissive FRET nanoprobes (PDFNPs) that undergo a distinct ratiometric fluorescence peak shift upon disassembly, we achieve real‐time, quantitative tracking of dissolution kinetics in live cells.
Farsai Taemaitree, Jinwoo Sung, Yutaro Miki, Ryuju Suzuki, Yoshitaka Koseki, Kunikazu Ishii, Minsang Kim, Keita Tanita, Kota Sato, Toru Nakazawa, Satoshi Katsube, Daisuke Unabara, Tasuku Hamaguchi, Keisuke Kawakami, Koji Yonekura, Akihide Hibara, Atsushi Wakamiya, Hiroshi Uji‐I, Hitoshi Kasai   +18 more
wiley   +1 more source

lncRNA NEAT1 mediates sepsis progression by regulating Irak2 via sponging miR-370-3p

Biology Open, 2020
Sepsis is a life-threatening condition and often associated with multiple organ failure. Nuclear-enriched abundant transcript 1 (NEAT1), a member of the long non-coding RNAs (lncRNAs), was reported to be involved in the regulation of sepsis progression ...
Ting Xiao, Chuihua Sun, Ying Xiao, Yunbao Li   +3 more
doaj   +1 more source

Aldosterone induced galectin-3 expression mainly through MRs in macrophage cell line Raw 264.7.

, 2014
Raw 264.7 cells(1×106/ml) were serum-starved for 24 h, then treated with 10−7 M of spironolactone or 10−7 M of RU-486 for 1 h, followed by 10−6 M aldosterone or vehicle treatment for 24 h.
Ying-Hsien Chen (309332), Xue-Ming Wu (624751), Vin-Cent Wu (111853), Yi-Lwun Ho (224736), Yi-Yao Chang (624752), Yen-Hung Lin (224739), Chia-Hung Chou (426474), Fon-Jou Hsieh (194587), Yu-Lin Tzeng (624753), Chi-Sheng Hung (405362), Kwan-Dun Wu (141755)   +10 more
core   +1 more source

An Injectable ROS‐Responsive Nanozyme Hydrogel Regulates the Uterine Microenvironment to Prevent Intrauterine Adhesions

Advanced Science, EarlyView.
The injectable CeTA@GPP hydrogel is administered via intrauterine injection, forming a protective barrier. In the high ROS inflammatory microenvironment of injured endometrium, boronate ester cleavage triggers responsive CeTA release and local enrichment.
Peixian Cheng, Jian Song, Yuxin Li, Ming Chen, Zeshen Liang, Binyao Qiu, Xuemin Liu, Xuetao Shi, Yong Fan   +8 more
wiley   +1 more source

RAW 264.7 cell phagocytosis assay v1

This protocol describes in vitro methods for evaluating phagocytosis using the macrophage-like cell line, RAW 264.7. The two methods discussed here include (1) a photographic phagocytosis assay, which is compatible with any target that is visible via 100x microscopy, and measures total uptake of target material per macrophage, and (2) the phagocytosis ...
Matthew Slarve, travis nielsen, Dongran Yu, Jordyn VanOrman, Brian Luna, Brad spellberg   +5 more
openaire   +1 more source

Inhibition of osteoclast differentiation and bone resorption by polyunsaturated fatty acids in RAW 264.7 murine macrophages. [PDF]

, 2011
This study investigated the effects of polyunsaturated fatty acids on osteoclast formation and bone resorption in RAW 264.7 murine pre-osteoclasts.
Joubert, Annie M., Coetzee, Magdalena, Kruger, Marlena C., Chua, Wei-Hang, Boeyens, Jan Christoffel Antonie, Kruger M, Coetzee M, Chua WH, Boeyens JCA, Joubert AM   +9 more
core   +1 more source

Force‐Electric Nanotentacles of Tantalum Implant Accelerate Cellular Energy Metabolism/Crosstalk for Immunomodulation‐Vascularized Bone Integration

Advanced Science, EarlyView.
A biomimetic force‐electric nanotentacle‐enabled tantalum (Ta) implant with surface‐nanostructured LiTaO3 (n‐LiTaO3) was first developed via laser nanofabrication combined with Li+‐induced in situ reaction, enabling the transduction of ultrasound into bioelectrical cues.
Taixing Zhang, Ke Ma, Kangqing Zuo, Pandong Lin, Tailong Zhang, Rongliang Ding, Linbo Zhang, Aonan Li, Yinchuan Wang, Yanling Huang, Jichao Feng, Guiyong Xiao, Yupeng Lu, Bing Han, Zhiqiang Wang, Ningbo Li   +15 more
wiley   +1 more source

Berberine Inhibits the Inflammatory Response Induced by Staphylococcus aureus Isolated from Atopic Eczema Patients via the TNF-α/Inflammation/RAGE Pathways

Cells
Atopic eczema patients exhibit high levels of Staphylococcus aureus (S. aureus) skin colonization. S. aureus can stimulate macrophages and the expression of proinflammatory cytokines. Berberine (BBR), an alkaloid, attenuates S.
Anish R. Maskey, Daniel Kopulos, Matthew Kwan, Niradiz Reyes, Christian Figueroa, Xian Mo, Nang Yang, Raj Tiwari, Jan Geliebter, Xiu-Min Li   +9 more
doaj   +1 more source