Results 181 to 190 of about 5,986,284 (284)

Dental resin composites generate microparticles and impact on gingival keratinocytes—In vitro study

European Journal of Oral Sciences, EarlyView.
Abstract Along with our increased understanding of the spread of microplastic pollution, the awareness of microparticle release from medical and dental materials has increased. Still, their effects on human health are largely unknown. As the use of resin composite materials in dentistry continues to increase, it is essential to understand the formation
Ella Pullinen, Saara V. Sirkiä, Johan Nyman, Pekka K. Vallittu, Vuokko Loimaranta   +4 more
wiley   +1 more source

SHIP1 regulates TREM2 signalling and macrophage functions in a hiPSC‐derived model

The FEBS Journal, EarlyView.
In this study, we characterised the role of SHIP1 in regulating TREM2 signalling and global microglial myeloid functions using human‐induced pluripotent stem cell (hiPSC)‐derived macrophages. Knockout of SHIP1 (SHIP1 KO) in macrophages decreased inflammatory activation and levels of scavenger receptors. SHIP1 KO macrophages also exhibited reduced TREM2
Kim S. Martin, Juliane Obst, Shania Ibarra, Emma J. Murphy, Katerina O. Gospodinova, Emma Mead   +5 more
wiley   +1 more source

Immunometabolic Modulation by Low‐Dose Sodium Butyrate: PI3K/Akt/mTOR Signalling Orchestrates Macrophage Polarization to Protect Against Clostridioides difficile Colitis

Immunology, EarlyView.
Clostridioides difficile toxins TcdA and TcdB enter intestinal epithelial cells (IECs) via specific receptors, disrupt tight‐junction integrity and activate PI3K/Akt/mTOR signalling, promoting inflammasome assembly and IL‐1β release. Toxin‐induced IEC apoptosis further weakens the epithelial barrier.
Sisi Zhang, Zhou Jingxiang, Caixia Tan, Yuanyuan Xiao, Ju Zou, Biyue Tian, Anhua Wu, Chunhui Li   +7 more
wiley   +1 more source

IL15.3, a synthetic antimicrobial peptide, attenuates LPS-induced inflammatory responses in RAW 264.7 macrophages via transcriptional and proteomic modulation. [PDF]

PLoS One
Boonmark C, Roytrakul S, Saengyotha F, Tankrathok A, Wanthong A, Daduang J, Daduang S, Chaveerach A, Jangpromma N.   +8 more
europepmc   +1 more source

Stem Cells From Dental Pulp, Periodontal Tissues, and Other Oral Sources: Biological Concepts and Regenerative Potential

Journal of Periodontal Research, EarlyView.
A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed, Sara El Moshy, Israa Ahmed Radwan, Dina Rady, Aiah A. El‐Rashidy, Marwa M. S. Abbass, Christof E. Dörfer   +6 more
wiley   +1 more source

Modulation of Osteogenesis by Conditioned Media of Differently Activated Macrophages: A Comparative In Vitro Study. [PDF]

Int J Mol Sci
Najman SJ, Živković J, Stojanović S.
europepmc   +1 more source

Next Generation Smart Implant Surfaces: Engineering Multifunctional Antimicrobial, Immunomodulatory and Regenerative Interfaces

Journal of Periodontal Research, EarlyView.
Natural‐inspired nano‐textured implant surfaces can be functionalised to modulate macrophage polarisation and local immune responses. This bioactive control promotes improved tissue integration and healing outcomes. ABSTRACT Dental implants rely on a stable and functional interface between the implant surface, surrounding tissues, and the oral ...
Roberto S. Pessoa, Lauren E. Steele, Mehvish Mumtaz, Denver P. Linklater, Neil M. O'Brien‐Simpson, Vladimir Baulin, Peter Kingshott, Roy Judge, Alastair J. Sloan, Elena P. Ivanova   +9 more
wiley   +1 more source

Pulsed Electric Field-Induced Ablation of Atherosclerotic Plaque-Forming Cells: A Preliminary In Vitro Investigation. [PDF]

J Cardiovasc Dev Dis
Jing Y, Xue Z, Cui X, Wu Y, Ye X, Lu C, Yin H, Liu M, Sun X, Zhang Z.   +9 more
europepmc   +1 more source

Combined Effects of Romosozumab and Zoledronate on the Development of Osteonecrosis of the Jaw

Oral Diseases, EarlyView.
ABSTRACT Objective This study aimed to assess the occurrence of medication‐related osteonecrosis of the jaw (MRONJ) in mice following the sequential administration of romosozumab and zoledronate and to confirm their inhibitory effects on osteoclast differentiation in vitro.
Hae‐Seo Park, Shihyun Kim, Seo‐Yeong An, Reuben H. Kim, Jongho Choi, Moon‐Young Kim   +5 more
wiley   +1 more source

Multimodal Analytical Platform Coupled With Biological Assays Unravels Tissue‐Specific Chemical Profiles, Spatial Metabolite Distributions and Bioactivities of Root Xylem and Root Bark of Tripterygium wilfordii

Analytical Science Advances, Volume 7, Issue 2, December 2026.
ABSTRACT Characterising chemical and biological differences among different tissues of medicinal plants is important for understanding their tissue‐specific characteristics and medicinal efficacy. The root xylem (RX) and root bark (RB) of Tripterygium wilfordii have historically been used differently; however, the basis underlying their differential ...
Zhong Mou Zhang, Kai Ling Xu, Qing Zhang, Yong Qiang Lin, Feng Wei, Ya Dan Wang   +5 more
wiley   +1 more source