Results 31 to 40 of about 134,959 (219)

Ecological Restoration of Antibiotic-Disturbed Gastrointestinal Microbiota in Foregut and Hindgut of Cows

Frontiers in Cellular and Infection Microbiology, 2018
Antibiotically disturbed gastrointestinal microbiota needs a long period time to be restored to normal, which may cause a series of problems to the host.
Shoukun Ji, Tao Jiang, Tao Jiang, Hui Yan, Chunyan Guo, Chunyan Guo, Jingjing Liu, Huawei Su, Gibson M. Alugongo, Haitao Shi, Yajing Wang, Zhijun Cao, Shengli Li   +12 more
doaj   +1 more source

The Antioxidant Properties of Selenium and Vitamin E; Their Role in Periparturient Dairy Cattle Health Regulation

Antioxidants, 2021
Dairy cattle experience health risks during the periparturient period. The continuous overproduction of reactive oxygen species (ROS) during the transition from late gestation to peak lactation leads to the development of oxidative stress.
Jianxin Xiao, Muhammad Zahoor Khan, Yulin Ma, Gibson Maswayi Alugongo, Jiaying Ma, Tianyu Chen, Adnan Khan, Zhijun Cao   +7 more
doaj   +1 more source

Effect of Limit-Fed Diets With Different Forage to Concentrate Ratios on Fecal Bacterial and Archaeal Community Composition in Holstein Heifers

Frontiers in Microbiology, 2018
Limit-feeding of a high concentrate diet has been proposed as an effective method for improving feed efficiency and reducing total manure output of dairy heifers; meanwhile the effects of this method on hindgut microbiota are still unclear.
Jun Zhang, Haitao Shi, Haitao Shi, Yajing Wang, Zhijun Cao, Hongjian Yang, Shengli Li   +6 more
doaj   +1 more source

Complementary hepatic metabolomics and proteomics reveal the adaptive mechanisms of dairy cows to the transition period

Journal of Dairy Science, 2023
: The transition period from late pregnancy to early lactation is a vital time of the lifecycle of dairy cows due to the marked metabolic challenges. Besides, the liver is the pivot point of metabolism in cattle.
Jun Zhang, Naren Gaowa, Yajing Wang, Huanxu Li, Zhijun Cao, Hongjian Yang, Xiaoming Zhang, Shengli Li   +7 more
doaj   +1 more source

Novel Process Methods for the Whole Cottonseed: Effect on the Digestibility, Productivity, Fat Profile, and Milk Gossypol Levels in Lactating Dairy Cows

Frontiers in Nutrition, 2022
In this study, we aimed to determine the effect of mixed-process methods on the ruminal degradability of whole cottonseed (WCS) both in situ and in vitro, and the effect on the production performance of dairy cows.
Xiaoge Sun, Yitong Su, Yangyi Hao, Jun Zhang, Xiaomei Yue, Wei Wang, Zhu Ma, Kangkang Chu, Shuang Wang, Yajing Wang, Shengli Li   +10 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Preparing the Gut with Antibiotics Enhances Gut Microbiota Reprogramming Efficiency by Promoting Xenomicrobiota Colonization

Frontiers in Microbiology, 2017
Gut microbiota plays multiple important roles in intestinal and physiological homeostasis, and using fecal microbiota transplantation (FMT) to reprogram gut microbiota has demonstrated promise for redressing intestinal and physiological disorders.
Shou K. Ji, Hui Yan, Tao Jiang, Tao Jiang, Chun Y. Guo, Chun Y. Guo, Jing J. Liu, Shuang Z. Dong, Kai L. Yang, Ya J. Wang, Zhi J. Cao, Sheng L. Li   +11 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Overview of the effect of rumen-protected limiting amino acids (methionine and lysine) and choline on the immunity, antioxidative, and inflammatory status of periparturient ruminants

Frontiers in Immunology, 2023
Overproduction of reactive oxygen species (ROS) is a well-known phenomenon experienced by ruminants, especially during the transition from late gestation to successful lactation.
Muhammad Zahoor Khan, Muhammad Zahoor Khan, Shuai Liu, Yulin Ma, Mei Ma, Qudrat Ullah, Ibrar Muhammad Khan, Jingjun Wang, Jianxin Xiao, Tianyu Chen, Adnan Khan, Zhijun Cao   +11 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source