Results 51 to 60 of about 389,945 (292)

Early Onset Ataxia with Comorbid Dystonia: Clinical, Anatomical and Biological Pathway Analysis Expose Shared Pathophysiology

Diagnostics, 2020
In degenerative adult onset ataxia (AOA), dystonic comorbidity is attributed to one disease continuum. However, in early adult onset ataxia (EOA), the prevalence and pathogenesis of dystonic comorbidity (EOAD+), are still unclear.
Deborah A. Sival, Martinica Garofalo, Rick Brandsma, Tom A. Bokkers, Marloes van den Berg, Tom J. de Koning, Marina A. J. Tijssen, Dineke S. Verbeek   +7 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Improved [¹⁸F]FDG PET/CT Diagnostic Accuracy for Infective Endocarditis Using Conventional Cardiac Gating or Combined Cardiac and Respiratory Motion Correction (CardioFreeze^TM)

Diagnostics, 2023
Infective endocarditis (IE) is a serious and diagnostically challenging condition. [18F]FDG PET/CT is valuable for evaluating suspected IE, but it is susceptible to motion-related artefacts.
D. ten Hove, B. Sinha, J. H. van Snick, R. H. J. A. Slart, A. W. J. M. Glaudemans   +4 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Cardiac Magnetic Resonance Derived Left Ventricular Eccentricity Index and Right Ventricular Mass Measurements Predict Outcome in Children with Pulmonary Arterial Hypertension

Children, 2023
Pulmonary arterial hypertension (PAH) is associated with increased right ventricular (RV) afterload, affecting RV remodeling and RV performance, a major determinant of outcome in PAH-patients.
Meindina G. Haarman, Iris Coenraad, Quint A. J. Hagdorn, Hans L. Hillege, Tineke P. Willems, Rolf M. F. Berger, Johannes M. Douwes   +6 more
doaj   +1 more source

RB and Cdc2 expression in brain: correlations with 3H-thymidine incorporation and neurogenesis

, 1993
Expression of the cell cycle regulatory proteins RB and p34cdc2 was examined in the adult rat brain, with special emphasis on proliferation and neuronal differentiation in the hippocampal formation and olfactory bulb. RB-like immunoreactivity (RB-IR) was
HJ Okano, RB Gibbs, DW Pfaff
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Beware of the Iceberg Phenomenon: A Case Report of Chest Wall Fibrous Dysplasia

Diagnostics
Thoracic fibrous dysplasia (FD) is a benign, osseous chest wall tumor. It originates from bone marrow and accounts for 30–50% of all benign osseous neoplasms in the chest wall. In FD, normal bone marrow is replaced by fibrous stroma and immature bone. We
Vincent van Suylen, Rienhart F. E. Wolf, Wobbe Bouma, Caroline Van De Wauwer, Albert J. H. Suurmeijer, Massimo A. Mariani, Theo J. Klinkenberg   +6 more
doaj   +1 more source

Left atrial volume and left ventricular mass indices in heart failure with preserved and reduced ejection fraction

ESC Heart Failure, 2021
Aims Two key echocardiographic parameters that are currently used to diagnose heart failure (HF) with preserved ejection fraction (HFpEF) are left atrial volume index (LAVi) and left ventricular mass index (LVMi).
Carolin Gehlken, Elles M. Screever, Navin Suthahar, Peter van derMeer, B. Daan Westenbrink, Jennifer E. Coster, Dirk J. Van Veldhuisen, Rudolf A. deBoer, Wouter C. Meijers   +8 more
doaj   +1 more source

RB depletion is required for the continuous growth of tumors initiated by loss of RB. [PDF]

, 2021
The retinoblastoma (RB) tumor suppressor is functionally inactivated in a wide range of human tumors where this inactivation promotes tumorigenesis in part by allowing uncontrolled proliferation.
Lukas E Dow, Shue, Yan Ting, Andrea C Chaikovsky, Arand, Julia, Yan Ting Shue, David M Feldser, Diana Gong, Myung Chang Lee, Skotheim, Jan M, Alexandros P Drainas, Gong, Diana, Vogel, Hannes, Walter, David M, Hannes Vogel, Julien Sage, Sage, Julien, David M Walter, Alex Doan, Drainas, Alexandros P, Lee, Myung Chang, Zhang, Shuyuan, Doan, Alex, Dow, Lukas E, Jan M Skotheim, Feldser, David M, Julia Arand, Chaikovsky, Andrea C, Shuyuan Zhang   +27 more
core   +1 more source