Results 291 to 300 of about 107,123 (321)

Ginsenoside Rb1 attenuates doxorubicin induced cardiotoxicity by suppressing autophagy and ferroptosis.

Biochemical and Biophysical Research Communications - BBRC
Ginsenoside Rb1 (Rb1), an active component isolated from traditional Chinese medicine Ginseng, is beneficial to many cardiovascular diseases. However, whether it can protect against doxorubicin induced cardiotoxicity (DIC) is not clear yet. In this study,
Yafei Zhai, Jinmeng Bai, Ying Peng, Jinhua Cao, Guangming Fang, Yiming Dong, Ze Wang, Yanyu Lu, Mengyu Wang, Mengduan Liu, Yangyang Liu, Xiaowei Li, Jianzeng Dong, Xiaoyan Zhao   +13 more
semanticscholar   +1 more source

Preparation of pH-sensitive carboxymethyl chitosan nanoparticles loaded with ginsenoside Rb1 and evaluation of drug release in vitro.

International Journal of Biological Macromolecules
Oral absorption of ginsenoside Rb1 (Rb1) is often hindered by the gastrointestinal tract. Carboxymethyl chitosan deoxycholic acid loaded with ginsenoside Rb1 nanoparticles (CMDA@Rb1-NPs), were prepared as a delivery system using a self-assembly technique
Ziyuan An, Yujia Dong, Wanying Wang, Jiani Wang, Zhansheng Wu, Wenfei Wang, Yanhui He, Guoqiang Bao   +7 more
semanticscholar   +1 more source

Ginsenoside-Rb1 prevents bone cartilage destruction through down-regulation of p-Akt, p-P38, and p-P65 signaling in rabbit.

Phytomedicine, 2022
BACKGROUND Osteoarthritis (OA) is the most common joint complaint resulting in pain, disability, and loss of quality of life. On the other hand, ginsenoside-Rb1 is a plant product derived from ginseng that possesses immune-regulation and anti ...
M. A. Hossain, J. Alam, Bumseok Kim, C. Kang, Jong-Hoon Kim   +4 more
semanticscholar   +1 more source

Compound Genomic Alterations of TP53, PTEN, and RB1 Tumor Suppressors in Localized and Metastatic Prostate Cancer.

European Urology, 2019
BACKGROUND TP53, PTEN, and RB1 tumor suppressor genes (TSGs) are recurrently altered in treatment-resistant prostate cancer. Cooperative loss of two or more TSGs may drive more aggressive disease.
A. Hamid, K. Gray, G. Shaw, L. Macconaill, Carolyn P. Evan, Brandon Bernard, M. Loda, N. Corcoran, E. V. Van Allen, A. Choudhury, C. Sweeney   +10 more
semanticscholar   +1 more source

RB1 deletion in gonadoblastoma in an XY female

Human Genetics, 1997
Cytogenetic studies of normal and tumor cells in a patient with gonadal dysgenesis and bilateral gonadoblastoma were performed. The karyotype was 46,XY in peripheral blood lymphocytes and skin fibroblasts. The conserved region of the SRY gene was detected by polymerase chain reaction amplification.
S, Antonini, A S, Barbosa, C, Rosenberg, A C, Barbosa, A C, Moreira-Filho, A M, Vianna-Morgante   +5 more
openaire   +2 more sources

Ginsenoside Rb1 exerts anti-inflammatory effects in vitro and in vivo by modulating toll-like receptor 4 dimerization and NF-kB/MAPKs signaling pathways.

Phytomedicine, 2020
BACKGOUND Ginsenoside Rb1, the main active constituent of Panax ginseng, displays significant anti-inflammatory activity, although the mechanism has not been clearly unraveled. In this study, Rb1's mechanism of anti-inflammatory effects were investigated.
Hongwei Gao, Nai-xin Kang, Chao Hu, Ziyu Zhang, Qiongming Xu, Yanli Liu, Shilin Yang   +6 more
semanticscholar   +1 more source

Differential effects of ginsenoside Rb1 and malonylginsenoside Rb1 on long-term potentiation in the dentate gyrus of rats

Brain Research, 1994
Ginseng saponins are known to have various pharmacological actions on the central nervous system. In the present study, we investigated the effects of ginsenoside Rb1 (GRb1) and malonylginsenoside Rb1 (GRb1-m) on the induction of long-term potentiation (LTP) in the dentate gyrus using anesthetized rats.
K, Abe, S I, Cho, I, Kitagawa, N, Nishiyama, H, Saito   +4 more
openaire   +2 more sources

A splicing mutation in RB1 in low penetrance retinoblastoma

Human Genetics, 1997
The pediatric eye-tumor retinoblastoma is widely held as a paradigm of human cancer genetics and has been a model system for both the two-hit hypothesis of dominantly inherited cancer as well as for the concept of tumor-specific loss of constitutional heterozygosity to achieve expression of the tumorigenic phenotype.
E L, Schubert, L C, Strong, M F, Hansen
openaire   +2 more sources

[Research advances on RB1 gene].

Yi chuan = Hereditas, 2011
The retinoblastoma1 (RB1) gene is the first cloned tumor suppressor gene. As a negative regulator of the cell cycle, RB1 gene could maintain a balance between cell growth and development through binding to transcription factors and regulating the expression of genes involved in cell proliferation and differentiation. Thus, it is involved in cell cycle,
Shuang-Hu, Liu, Shou-Zhi, Wang, Hui, Zhang, Hui, Li   +3 more
openaire   +1 more source

Intestinal Lactobacillus species improve immune enhancement by ginsenoside Rb1 and ginsenoside Rb1 increases intestinal Akkermansia proportions

Journal of Functional Foods, 2021
Yohan Yoon, Jeeyeon Lee
exaly