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Table_1_Neutralizing Potency of Prototype and Omicron RBD mRNA Vaccines Against Omicron Variant.xlsx

, 2022
The newly emerged Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contains more than 30 mutations on the spike protein, 15 of which are located within the receptor binding domain (RBD).
Yannan Yin (10689001) +8 more
core +1 more source

An Oral Antiviral Combination Against Severe COVID‐19 Enabled by the Synergistic Mechanisms of Action of Auranofin and Remdesivir

Advanced Science, EarlyView.
FDA‐approved anti‐inflammatory drug Auranofin inhibits SARS‐CoV‐2 replication by inhibiting viral Main protease activity and Spike processing required for viral entry. It shows strong synergy with nucleoside analogue Remdesivir, due to non‐overlapping mechanisms.
Oyahida Khatun +13 more
wiley +1 more source

Correlation and underlying brain mechanisms between rapid eye movement sleep behavior disorder and executive functions in Parkinson’s disease: an fNIRS study

Frontiers in Aging Neuroscience
PurposeRapid eye movement sleep behavior disorder (RBD) affects 30%–40% of patients with Parkinson’s disease (PD) and has been linked to a higher risk of cognitive impairment, especially executive dysfunction. The aim of this study was to investigate the
Lu Ren +9 more
doaj +1 more source

VLP-RBD vaccine induces high-titer antibody responses in mice.

, 2021
Mice were immunized with RBD, VLP-RBD-M (VLP was prepared from mammalian cells), VLP-RBD-E (VLP was prepared from bacterial cells), or PBS. Mouse sera were collected on day 10 post-2nd immunization for detection of RBD-specific antibodies (A) and spike ...
Jian Shang (1358481) +20 more
core +1 more source

Arhgef1 Deletion Disrupts Early Cortical Neurogenesis via PAK1 Overactivation and Causes Motor Dysfunction in Adulthood

Advanced Science, EarlyView.
ARHGEF1 plays a pivotal role in both embryonic cortical neurogenesis and adult motor function. During early development, it governs genesis of deep‐layer cortical neurons by negatively regulating RAC1/CDC42‐PAK1‐Cofilin signaling. In adulthood, ARHGEF1 is important for the maintenance of neuronal morphology and activity in the motor cortex, ensuring ...
Liuren Li +14 more
wiley +1 more source

RBD-Ig and ACE2-Ig bind their respective targets.

, 2021
(A) Schematic representation of our proposed treatments. (Left panel) SARS-CoV-2 spike protein binds to the ACE2 receptor on host cells to mediate virus entry.
Orit Berhani (11136072) +15 more
core +1 more source

Structural and biophysical evidence of simultaneous binding of two RBD-chAbs to SARS-CoV-2 S protein.

, 2021
A. Overlay of cryo-EM maps of the Fabs of chAb-25 and -45 to the same RBD. The color scheme is the same as that of Fig 4.B. Size-exclusion chromatograms (SEC) of the free S protein (black), RBD-chAb-25-bound S protein (orange), RBD-chAb-45 bound S ...
Mei-Jung Wang (219858) +29 more
core +1 more source

Assessing prevalence and risk factors for REM sleep behavior disorder among patients with inflammatory bowel disease

npj Parkinson's Disease
REM sleep behavior disorder (RBD) and inflammatory bowel disease (IBD) are associated with Parkinson’s Disease. Using a cross-sectional design, we assessed RBD prevalence in IBD and controls.
Vijaya L. Reddy +11 more
doaj +1 more source

Prevalence and impact of rapid eye movement sleep behavior disorder in multiple system atrophy: a systematic review and meta-analysis

Frontiers in Neurology
ObjectiveMultiple system atrophy (MSA) is commonly associated with rapid eye movement sleep behavior disorder (RBD). Research on the prevalence of RBD in MSA and its effects on MSA patients has yielded inconsistent results.
Hui Wang, Ting Zhang, Wenhui Fan
doaj +1 more source

Surface plasmon resonance sensorgrams of RBD variants.

, 2023
Surface plasmon resonance sensorgrams of RBD variants.
Harsh Bansia (9381458) +17 more
core +1 more source

sars-cov-2
covid-19
receptor-binding domain

medicine
spike
adjuvant

subunit vaccine
neurology