Results 91 to 100 of about 82,493 (288)

RSF1‐Dependent PAR Turnover Promotes 53BP1 Liquid Condensate Formation at DNA Damage Sites

Advanced Science, EarlyView.
At sites of DNA damage, RSF1 recruits PARG to accelerate PAR turnover, triggering a switch from PAR‐driven condensates to 53BP1 condensates. This condensate transition enables p53‐dependent gene transcription and coordinates the DNA damage response.
Yungyeong Heo, Yonghyeon Kim, Nangyeong Hwang, Gwanho Sung, Sujin Jo, Yeonhu Lee, Ho‐Chul Kang, Jae‐Ho Lee, Yong Won Choi, Hyeseong Cho, Sunwoo Min   +10 more
wiley   +1 more source

Mannans: Obtaining from the cell walls of Saccharomyces cerevisiae yeast and assessing their adjuvant properties in a subunit vaccine model

Acta Biomedica Scientifica
Background. Polysaccharides are known to possess adjuvant properties, they are biodegradable, safe, and are of low-labor production. In this regard, the development of polysaccharide-based adjuvants is an urgent task.The aim.
T. I. Esina, E. A. Volosnikova, D. N. Shcherbakov, N. V. Volkova, A. V. Zaykovskaya, G. G. Shimina, E. D. Danilenko   +6 more
doaj   +1 more source

Switching Spike Plasticity Shapes ACE2 Engagement Across SARS‐CoV‐2 Variants

Advanced Science, EarlyView.
Conformational plasticity governs SARS‐CoV‐2 spike function and ACE2 recognition. Using high‐speed AFM and single‐molecule force spectroscopy, we analyzed the ancestral spike and nine variants, revealing progressive rigidification from Delta, variable plasticity in Omicron sublineages, and JN.1 compaction.
Sarah Stainer, Rong Zhu, Manuel Reithofer, Gerhard Stadlmayr, Katharina Stadlbauer, Panchika Prangkio, Christoph Rippel, Markus Hahn, Aniko Eva Kasztner, Stefanie Stohl, Petr Bednar, Daniel Ruzek, David Glück, Robert Tampé, Gordana Wozniak‐Knopp, Yoo Jin Oh, Miriam Klausberger, Peter Hinterdorfer   +17 more
wiley   +1 more source

Comparison of the BSA between RBD variants and ACE2 with that of the ACE2&RBD wildtype started from the crystal structure.

, 2023
Comparison of the BSA between RBD variants and ACE2 with that of the ACE2&RBD wildtype started from the crystal structure.
George Rucker (17101889), Hong Qin (279614), Liqun Zhang (115900)   +2 more
core   +1 more source

Intelligent Programmable Membrane Nanosponge for Early Virus Blocking

Advanced Science, EarlyView.
A smart programmable nanosponge (ACNPs) displays high‐density viral receptors on its membrane and encapsulates fusion inhibitors to capture virions at the infection source through competitive binding and blocks their entry through protease inhibition for ultra‐early cascade interception. This modular, mucus‐penetrating platform shifts antiviral defence
Ze Chen, Zhuojun He, Huimin Guo, Min Shi, Ruijing Liang, Lanlan Liu, Yeneng Dai, Qi Zhao, Ke Liu, Yang Zhou, Yang Zhang, Jian Ren, Bin Ju, Quan Fang, Zhaozhen Li, Pengfei Zhao, Mingbin Zheng, Lintao Cai   +17 more
wiley   +1 more source

DataSheet_1_Neutralizing Potency of Prototype and Omicron RBD mRNA Vaccines Against Omicron Variant.pdf

, 2022
The newly emerged Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contains more than 30 mutations on the spike protein, 15 of which are located within the receptor binding domain (RBD).
Yannan Yin (10689001), Shiqi Xu (2059951), Zhong Huang (358974), Weihua Qiao (119099), Haikun Wang (1905514), Jinkai Zang (11996706), Dimitri Lavillette (232360), Chao Zhang (51048), Qiuyue Liu (4855696)   +8 more
core   +1 more source

Prion‐Like Protein LENG8‐Mediated Nucleation Drives Stress Granule Assembly

Advanced Science, EarlyView.
LENG8 is a newly identified stress granule (SG) nucleator required for SG assembly. Following stress, nuclear LENG8 granules disassemble, allowing LENG8 to translocate into the cytoplasm and form independent nucleation foci. These foci fuse with canonical early G3BP1/TIA1 seeds via LENG8‐TIA1 binding to drive SG maturation.
Mingxing Zhang, Xin Wang, Yilan Teng, Zhicheng Wu, Jing Fan, Hongwen Zhu, Peng Dai   +6 more
wiley   +1 more source

Analisis Penurunan Kualitas Minyak Kelapa RBD dan Non-RBD Setelah Pemakaian Berulang: Studi Bilangan Asam dan Peroksida [PDF]

Pemakaian berulang minyak goreng dapat mempengaruhi kualitas minyak, yang pada akhirnya mempengaruhi nilai gizi makanan dan dapat menimbulkan resiko kesehatan.
Zahara, Budi, Efendi, Jon
core   +2 more sources

REM sleep behavior disorder (RBD)

Neurobiology of Disease, 2020
Since its first description in 1986 by Dr. Carlos Schenck, and his group's subsequent report of the delayed emergence of a Parkinsonian disorder in idiopathic RBD patients one decade later, RBD has emerged in recent years as one of the most promising markers of prodromal Parkinson's (References 2, 3). RBD is present in 25-58% of patients with Parkinson'
openaire   +3 more sources

MODIFICATION OF RBD PALM KERNEL AND RBD PALM STEARIN OIL WITH ZDDP ADDITIVE ADDITION

Jurnal Teknologi, 2015
Vegetable oils have gained worldwide concern due to environmental issues since it is biodegradable, renewable and environmental-friendly. However, the limitations of vegetable oils such as having low oxidation stability and poor low temperature properties need to be solved.
Farhanah, A. N., Samion, Syahrullail, Musa, Md. Nor, Bahak, M. Z.   +3 more
openaire   +2 more sources