Results 71 to 80 of about 82,493 (288)
Acta Biomedica ScientificaBackground. Squalene represents a promising basis for the development of novel adjuvant compositions with efficacy comparable to traditional adjuvants but with an improved safety profile.Objective.
E. A. Volosnikova +10 more
doaj +1 more source
Neutralizing Potency of Prototype and Omicron RBD mRNA Vaccines Against Omicron Variant
Frontiers in Immunology, 2022 The newly emerged Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contains more than 30 mutations on the spike protein, 15 of which are located within the receptor binding domain (RBD).
Jinkai Zang +8 more
doaj +1 more source
Parkinson Disease Subtype Stability and Eventual Convergence
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Previous research identified distinct Parkinson disease (PD) clinical subtypes of “Motor Only,” “Psychiatric & Motor,” and “Cognitive & Motor” based on comprehensive, multidomain classification. Whether these subtypes reflect distinct trajectories or progressive disease stages remains unknown.
Laura M. Rosok +10 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.An ultrathin azide‐functionalized carbon nanomembrane (N3‐CNM) provides a versatile biointerface for antibody immobilization on gold SPR sensors. Integrated with a multichannel SPR platform, the functionalized surface enables label‐free, simultaneous detection of SARS‐CoV‐2, Influenza A, and RSV antigens, demonstrating the potential of CNM‐based ...
Ghazaleh Eshaghi +6 more
wiley +1 more source
Frontiers in Immunology, 2021 The increase in confirmed COVID-19 cases and SARS-CoV-2 variants calls for the development of safe and broad cross-protective vaccines. The RBD of the spike protein was considered to be a safe and effective candidate antigen.
Jintao Zou +14 more
doaj +1 more source
Superimposition of the structures for Nb-015/S-RBD and CB6/S-RBD complexes [PDB code: 7C01] [74].
, 2023 Nanobody Nb-015 and antibody CB6 are shown in cartoon and colored by cyan and orange, respectively. S-RBD is depicted as magenta surface and the RBS-A site on RBD is shown in gray. (TIF)
Haoyu Ye (6588242) +21 more
core +1 more source
Advanced Science, EarlyView.Functional amyloid conversion of the translation regulator CPEB3 is essential for long‐term memory persistence. This study demonstrates that targeting this molecular switch with the anti‐amyloidogenic peptide QBP1 selectively blocks CPEB3 fibrillation without disrupting phase separation.
Paula López‐García +13 more
wiley +1 more source
, 2021 (A) The overall structure of anti-SARS-CoV mAb CR3022 and anti-SARS-CoV-2 mAb B38 bound with SARS-CoV-2 RBD. (B) The potential mechanism of reduction in binding affinity due to the loss of an interaction in the K417N mutation in SARS-CoV-2 RBD.
Kittikhun Wangkanont (1507636) +5 more
core +1 more source
Small Molecules to Destabilize the ACE2-RBD Complex: A Molecular Dynamics Study for Potential COVID-19 Therapeutics [PDF]
, 2020 The ongoing COVID-19 pandemic has infected millions of people, claimed hundreds of thousands of lives, and made a worldwide health emergency. Understanding the SARS-CoV-2 mechanism of infection is crucial in the development of potential therapeutics and ...
Mehdi, Nikfar +2 more
core +1 more source
Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis
Advanced Science, EarlyView.Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang +9 more
wiley +1 more source