Results 141 to 150 of about 82,493 (288)
The GBA1 p.E427K (p.E388K) Variant Is a Risk Factor for Synucleinopathies: A Meta‐Analysis
Movement Disorders, EarlyView.Abstract Background
Variants in GBA1 are important genetic risk factors for synucleinopathies, including Parkinson's disease (PD). Although several GBA1 variants are established risk or severity modifiers, the role of the p.E427K variant remains unclear.Leah V. Chifamba, Sitki Cem Parlar, Emma N. Somerville, Lang Liu, Eric Yu, Farnaz Asayesh, Jamil Ahmad, Meron Teferra, Jennifer A. Ruskey, Cheryl Waters, Oury Monchi, Yves Dauvilliers, Nicolas Dupré, Alla Timofeeva, Anton Emelyanov, Sofya Pchelina, Irina Miliukhina, Lior Greenbaum, Sharon Hassin‐Baer, Orly Goldstein, Mandy Radefeldt, Peter Bauer, Christian Beetz, Allison A. Dilliott, James C. Beck, Konstantin Senkevich, ROPAD Study Group, The Parkinson's Foundation PD GENEration Study, Christine Klein, Roy N. Alcalay, Ziv Gan‐Or +30 morewiley +1 more sourceDecoding Sleep Architecture from Ambulatory Basal Ganglia Signals in Parkinson's Disease
Movement Disorders, EarlyView.Abstract Background
Sleep architecture and circadian rhythms are frequently disrupted in Parkinson's disease (PD). BrainSense‐enabled neurostimulators combined with wearable technology enable chronic assessment of nocturnal brain activity, with potential for future diagnostics and personalized treatments. Objectives
To neurophysiologically characterize Alberto Averna, Elena Bernasconi, Aaron Colombo, Laura Alva, Mario Sousa, Michael Schuepbach, Ines Debove, Georg Kägi, Andreas Nowacki, Claudio Pollo, Lenard Lachenmayer, Paul Krack, Syed Ahmar Shah, Damian Marc Herz, Benoit Duchet, Gerd Tinkhauser +15 morewiley +1 more sourceIntegrative Multi‐Omics Analysis Reveals Convergent Epigenome and Transcriptome Changes in Parkinson's Disease
Movement Disorders, EarlyView.Abstract Background
The mechanisms that predispose dopaminergic neurons (DAN) to degeneration in Parkinson's disease (PD) are incompletely understood. Objective
To perform an integrative multi‐omics reanalysis of single‐cell transcriptomic and epigenomic data to identify convergent alterations predisposing dopaminergic neurons to degeneration in ...Mirco Macchi, Aurélien Ginolhac, Tony Heurtaux, Borja Gomez‐Ramos, Lasse Sinkkonen, Enrico Glaab, on behalf of the NCER‐PD Consortium, Mariella Graziano, Alexandre Bisdorff, Rene Dondelinger, Elodie Thiry, Gelani Zelimkhanov, Guy Berchem, Liliana Vilas Boas, Linda Hansen, Martine Goergen, Nancy De Bremaeker, Nico Diederich, Romain Nati, Roxane Batutu, Sylvia Herbrink, Jochen Klucken, Rejko Krüger, Claire Pauly, Lukas Pavelka, Marijus Giraitis, Maria Fernanda Niño Uribe, Achilleas Pexaras, Alexander Hundt, Alexia Mendibide, Ana Festas Lopes, Angelo Ferrari, Brian Dewitt, Carlos Gamio, Estelle Henry, Gaël Hamot, Geeta Acharya, Hermann Thien, Ilsé Richard, Johanna Trouet, Kate Sokolowska, Katy Beaumont, Laura Georges, Lorieza Castillo, Lucie Remark, Maeva Munsch, Margaux Henry, Maud Theresine, Olga Kofanova, Olivia Roland, Pauline Lambert, Saïda Mtimet, Wim Ammerlaan, Anne Grünewald, Armin Rauschenberger, Clarissa P.C. Gomes, Dheeraj Reddy Bobbili, Ekaterina Soboleva, Elisa Gómez de Lope, Enrico Glaab, Evi Wollscheid‐Lengeling, Francoise Meisch, Giuseppe Arena, Ibrahim Boussaad, Iñigo Yoldi Bergua, Jens Schwamborn, Kirsten Roomp, Laure Pauly, Michael T. Heneka, Michele Bassis, Muhammad Ali, Jade Jaber, Patricia Martins Conde, Patrick May, Paul Wilmes, Piotr Gawron, Rebecca Ting Jiin Loo, Reinhard Schneider, Ruxandra Soare, Sabine Schmitz, Sarah Nickels, Sascha Herzinger, Sinthuja Pachchek, Soumyabrata Ghosh, Stefano Sapienza, Valentin Groues, Venkata Satagopam, Isabel Schwaninger, Liyousew Borga, Sijmen Van Schagen, Gabriel Martinez Tirado, Alan Castro Mejia, Messaline Fomo, Niloofar Kheradbin, Francesca Boschi, Francesca Terranova, Jochen Ohnmacht, Anne‐Marie Hanff, Carlos Vega, Chouaib Mediouni, Deborah Mcintyre, Eduardo Rosales, Fozia Noor, Gessica Contesotto, Gloria Aguayo, Guilherme Marques, Jérôme Graas, Joëlle Fritz, Magali Perquin, Manon Gantenbein, Maura Minelli, Michel Vaillant, Myriam Alexandre, Myriam Menster, Olena Tsurkalenko, Raquel Severino, Sibylle Béchet, Tainá M. Marques, Ulf Nehrbass, Victoria Lorentz, Zied Landoulsi, Sonja Jónsdóttir, David Bouvier, Katrin Frauenknecht, Michel Mittelbronn, Roseline Lentz, Jean‐Paul Nicolay, Nadine Jacoby +127 morewiley +1 more sourceConsistency of Serial Cerebrospinal Fluid α‐Synuclein Seed Amplification Assay Results in the Parkinson's Precision Medicine Initiative
Movement Disorders, EarlyView.Abstract Background
Studies reporting α‐synuclein seed amplification assay (aSyn‐SAA) results are often cross‐sectional. Objectives
In this study, we investigated the intraindividual consistency of aSyn‐SAA results (Amprion) over time from participants in the Parkinson's Precision Medicine Initiative (PPMI).David G. Coughlin, Caroline Gochanour, Jie Yin, Luis Concha‐Marambio, Carly Farris, Yihua Ma, David‐Erick Lafontant, Edwin Jabbari, Tanya Simuni, Ken Marek, Thomas F. Tropea, the Parkinson's Precision Medicine Initiative, Neha Prakash, Tanya Simuni, Nabila Dahodwala, Caroline Tanner, Lana Chahine, Brit Mollenhauer, Sebastian Schade, Douglas Galasko, Anat Mirelman, Roy Alcalay, Katherine Leaver, Marie Saint‐Hilaire, Ruth Schneider, Christopher Tarolli, Werner Poewe, Aleksandar Videnovic, David Standaert, Marissa Dean, Sonja Jonsdottir, Rejko Krueger, Claire Pauly, Stewart Factor, Penelope Hogarth, Robert Hauser, Amy Amara, Michelle Fullard, Cyrus Zabetian, Hubert Fernandez, Kathrin Brockmann, Isabel Wurster, Yen Tai, Paolo Barone, Marina Picillo, Stuart Isaacson, Alberto Espay, Eduardo Tolosa, Javier Ruiz Martinez, Leonidas Stefanis, Kelvin Chou, Lorraine Kalia, Connie Marras, David Grimes, Tiago Mestre, Rajesh Pahwa, Mark Lew, Holly Shill, Shyamal Mehta, Giulietta Riboldi, Nikolaus McFarland, Ron Postuma, Zoltan Mari, David Ledingham, Nicola Pavese, Michele Hu, Norbert Brueggemann, Christine Klein, Bastiaan Bloem, Cristina Simonet, Alastair Noyce, Anette Janzen, David Pedrosa, Wolfgang Oertel, Njideka Okubadejo, David Shprecher, Arjun Tarakad, Emile Moukheiber +77 morewiley +1 more sourceGCH1 p.Ser80Asn Confers Risk for Parkinson's Disease in East Asian Populations
Movement Disorders, EarlyView.Abstract Introduction
GCH1 has been implicated in Parkinson's disease (PD), but its risks variants and associations are not well defined. Objectives
Our goal was to investigate the clinical relevance and PD risk associated with the GCH1 p.Ser80Asn variant.Yi Wen Tay, Andrew Leslie Lee, Jie Ping Schee, Chin‐Hsien Lin, Eng King Tan, Jung Hwan Shin, Pin‐Shiuan Chen, Sung‐Pin Fan, Cheng‐Hsuan Li, Ebonne Yu Lin Ng, Han Joon Kim, Beomseok Jeon, Sulev Koks, Huyen Thi Thanh Vu, Kin Ying Mok, Yi Ting Lim, Mohd Salahuddin Kamaruddin, Tzi Shin Toh, Hans Xing Ding, Anis Nadhirah Khairul Anuar, Norlisah Ramli, Ignacio J. Keller Sarmiento, Maria Teresa Periñan, Zih‐Hua Fang, Lara M. Lange, Kishore R. Kumar, Soraya Bardien, Joanne Trinh, Enza Maria Valente, SG10K_Health Consortium, the Global Parkinson's Genetics Program (GP2), Peter Heutink, Katja Lohmann, Christine Klein, Niccolò E. Mencacci, Shen‐Yang Lim, Azlina Ahmad‐Annuar, Ai Huey Tan +37 morewiley +1 more sourceNeuropsychiatric and Cognitive Symptom Evolution over the First Decade of Biomarker‐Positive, Sporadic Parkinson's Disease
Movement Disorders, EarlyView.Abstract Background
Parkinson's disease (PD) is frequently accompanied by neuropsychiatric symptoms (NPS), including cognitive impairment, which often emerge early and co‐occur. Their long‐term evolution remains incompletely characterized, particularly in biomarker‐positive cohorts.Izabelle Schoen, Jing Wang, Sharon X. Xie, Chelsea Caspell‐Garcia, Eugenia Mamikonyan, Melanie Stark, Nabila Dahodwala, Andrew D. Siderowf, Roseanne Dobkin, Michele K. York, Daniel Weintraub +10 morewiley +1 more sourceHabitual Diet, Gut Microbiome Dysbiosis, and α‐Synucleinopathy Conversion in Isolated Rapid Eye Movement (REM) Sleep Behavior Disorder
Movement Disorders, EarlyView.Abstract Background
Accumulating evidence indicates that habitual diet, including plant‐based dietary patterns, is associated with neurodegenerative α‐synucleinopathy risk. However, the role of diet and its correlation with the gut microbiome in prodromal α‐synucleinopathy, specifically among patients with isolated rapid eye movement (REM) sleep ...Suyi Xie, Yuhua Yang, Shi Tang, Li Zhou, Jing Wang, Joey W.Y. Chan, Brian Or, Ningning Li, Siyi Gong, Zhixuan He, Jianzhang Ni, Yaping Liu, Jihui Zhang, Paul K.S. Chan, Zigui Chen, Sunny Hei Wong, Vincent C.T. Mok, Ngan Yin Chan, Steven W.H. Chau, Yun Kwok Wing, Bei Huang +20 morewiley +1 more source
