Results 161 to 170 of about 82,493 (288)

Molecular mechanism of KRAS binding to BRAF and its regulation by the BRAF-specific region. [PDF]

Structure
Bonsor DA, Sandin Lawrence SI, Tran TH, Swain M, Dharmaiah S, Mehalko J, Messing SA, Nissley DV, McCormick F, Stephen AG, Simanshu DK.   +10 more
europepmc   +1 more source

Kinetic signatures of RAS–BRAF engagement reveal isoform selectivity, oncogenic amplification, and mutation‐dependent inhibitor resistance

The FEBS Journal, EarlyView.
The BRAF N terminus uses a cooperative BSR–CRD gate that restricts RAS binding to the RBD, which can be mitigated by oncogenic RAS mutations. KRAS engages BRAF through stability‐driven, long‐lived complexes, whereas NRAS binds transiently in a frequency‐driven mode.
Sravani Malasani, Zhihong Wang
wiley   +1 more source

Probable Rapid Eye Movement Sleep Behavior Disorder Associated With Escitalopram in a Patient With Schizoaffective Disorder: A Case Report. [PDF]

Cureus
Bin Kamil AlShamsi MK, Ali MZ, Medhat Youssef H.   +2 more
europepmc   +1 more source

Enhancing the Evidence for Care in Underserved Bleeding Disorders Communities

Haemophilia, EarlyView.
ABSTRACT Background Major advances in haemophilia care have not translated equitably across all populations. Individuals with rare bleeding disorders (RBDs), people living in low‐ and lower‐middle‐income countries (LMICs) and women and girls with inherited bleeding disorders (WGWBD) continue to face significant diagnostic, therapeutic and research ...
Johnny Mahlangu
wiley   +1 more source

Disulfide bonds stabilize the SARS-CoV-2 RBD and preserve binding to ACE2 following thermal denaturation. [PDF]

Biosci Rep
McCann NR, Castellino FJ.
europepmc   +1 more source

Performing Large‐Scale Genetic Analysis in the Bleeding Disorders Community

Haemophilia, EarlyView.
ABSTRACT Inherited bleeding disorders encompass a diverse group of conditions caused by genetic defects affecting coagulation factors, fibrinogen, von Willebrand factor, or platelet function. Despite major advances in quantitative and functional laboratory assays, a substantial diagnostic gap remains, particularly in patients with mild or atypical ...
Anna R. Blankstein, Sterre P. E. Willems, Saskia E. M. Schols, Rosanna Asselta, Gillian Lowe, Neil V. Morgan, Paula D. James   +6 more
wiley   +1 more source

Computationally Guided Design and Experimental Validation of ssDNA Aptamers Targeting the SARS-CoV-2 Spike Protein. [PDF]

Biomolecules
Márquez Montesinos JCE, Bernardez AM, Mazola Y, Vaccaro L, Sáez-Álvarez Y, Agudo R, Valdivieso E, Llorens-Berzosa S, Fenoy S, González W, Izquierdo F, Ollero D, Del Aguila C, Hurtado-Marcos C.   +13 more
europepmc   +1 more source

Rare Bleeding Disorders and Bleeding Disorder of Unknown Cause: Current Understanding and Recent Developments

Haemophilia, EarlyView.
ABSTRACT Rare bleeding disorders (RBDs) represent a diverse group of inherited conditions involving coagulation factors or platelets. These conditions, such as Glanzmann thrombasthenia (GT) or severe coagulation factor deficiencies, are uncommon. In contrast, bleeding disorder of unknown cause (BDUC) is a diagnosis of exclusion without an identifiable ...
Alessandro Casini, Robert Klamroth, Bauke Haisma, Dino Mehic, Saskia E. M. Schols   +4 more
wiley   +1 more source

Construction and Immunogenicity Evaluation of a Ferritin-Based Nanoparticle Vaccine Displaying the PDCoV Spike Receptor-Binding Domain. [PDF]

Vet Sci
Cao S, Nie N, Zhang L, Chen C, Zhou M, Zhu S.   +5 more
europepmc   +1 more source

Mapping wild bee diversity and flower use for an effective conservation of the Doñana biodiversity hotspot

Insect Conservation and Diversity, EarlyView.
We compiled the first checklist of wild bees in Doñana Protected Area, documenting 385 species, including three vulnerable and one endangered species listed in the Red List. Bee species exhibit diverse floral preferences, highlighting the need to incorporate plant–pollinator interactions and the role of plants in conservation and management strategies ...
Francisco P. Molina, Nerea Montes‐Pérez, Luis Villagarcía, Ignasi Bartomeus   +3 more
wiley   +1 more source