Results 151 to 160 of about 82,493 (288)

Neuromelanin‐Sensitive MRI as a Marker of Clinical Severity and Disease Burden in Parkinson's Disease: A Systematic Review and Meta‐analysis

Movement Disorders, EarlyView.
Abstract The neuropathology of Parkinson's disease (PD) is characterized in part by the degeneration of catecholaminergic neurons, particularly dopaminergic neurons in the substantia nigra pars compacta (SNpc) and noradrenergic neurons in the locus coeruleus (LC), yet no validated in vivo biomarker quantifies this process.
Rayo Akande, Thomas Kustermann, Štefan Holiga, Judith Anzures‐Cabrera, Patrik Brundin, Gennaro Pagano   +5 more
wiley   +1 more source

Effects of Development Finance on Energy Transitions and Green Growth in Sub‐Saharan Africa

Sustainable Development, EarlyView.
ABSTRACT While global agendas promote energy transition and green growth, Africa south of the Sahara (SSA) struggles with low energy access, highlighting a development paradox between climate goals and energy poverty. By aligning aid and development finance with SDGs 7 and 13, we analyze whether development finance is at a crossroads in supporting ...
Clement Oteng, Pius Gamette, Edward Kweku Nunoo, Frederick Takyi   +3 more
wiley   +1 more source

Artificial intelligence in out‐of‐hospital sleep monitoring: Bridging polysomnography and wearable signals

Sleep Research, EarlyView.
Abstract Polysomnography (PSG), the reference standard for sleep assessment, has limited scalability for large‐scale screening, driving the development of wearable and unobtrusive monitors. However, the physiological signals these devices capture are physiologically correlated with PSG channels but are not completely equivalent.
Jing Yan, Zixi Huang, Haowen Zeng, Hanrong Cheng, Dongxing Zhao, Yuxi Luo   +5 more
wiley   +1 more source

High‐Throughput FRET Affinity Screening Technique (HTFAST) for Cell‐Free Expressed Binding Protein Characterization

Small, EarlyView.
High‐Throughput FRET Affinity Screening Technique (HTFAST) for quantitative, purification‐free affinity screening of cell‐free expressed binders. A fluorescent‐protein‐fused binder (donor) is expressed directly in crude E. coli cell‐free lysate and titrated against a dye‐labeled antigen (acceptor).
Sepehr Hejazi, Bret Lange, Kimia Noroozi, Vito Jurasic, Laura R Jarboe, Nigel F Reuel   +5 more
wiley   +1 more source

Harnessing the nonthermal effects of ultrasound for cancer treatment: From mechanisms to applications

Smart Molecules, EarlyView.
Nonthermal ultrasound transforms acoustic energy into diverse therapeutic bioeffects through cavitation, mechanical stimulation, and physicochemical activation. This review discusses how acoustic parameters, biological mechanisms, and responsive materials interact to influence nonthermal ultrasound‐enabled cancer therapies. Mechanism‐guided engineering
Liu Wang, Huan Tang, Yue Pan, Mingle Li, Weijie Zhao, Kai Liu   +5 more
wiley   +1 more source

Extraocular Photoreception in Optic Lobes, Suckers, and Skin of Octopus vulgaris

Integrative Zoology, EarlyView.
Evidence of extra‐ocular photoreception in Octopus vulgaris (a) Diagram of the O. vulgaris different tissues considered: SPB, sucker proximal big; SPL, sucker proximal large; SM, sucker medium; SD, sucker distal; SK, skin; OL, optic lobes; RT, retina; (b‐d) Gene expression analysis of Ov‐GRK1 (red), Ov‐retinochrome (green), Ov‐rhodopsin (blue) mRNA ...
Valeria Maselli, Al‐Sayed Al‐Soudy, Mariangela Norcia, Stefania Galdiero, Sara Palladino, Emanuela Cirillo, Gianluca Polese, Anna Di Cosmo   +7 more
wiley   +1 more source

Hydrophobic remodeling of the SARS-CoV-2 RBD large loop attenuates ACE2 engagement and viral fitness. [PDF]

PLoS Pathog
Wang A, Guo H, Yang H, Chen H, Imojara A, Ju B, Zhang Z, Yan R.   +7 more
europepmc   +1 more source

Daraxonrasib and Beyond: Pan‐RAS Inhibition, Resistance, and Next‐Generation Strategies

Cancer Science, EarlyView.
ABSTRACT RAS proteins have long been considered difficult therapeutic targets, but allele‐selective inhibitors established the clinical tractability of mutant RAS. Daraxonrasib (RMC‐6236), an oral pan‐RAS inhibitor, has now extended this concept by targeting multiple mutant and wild‐type RAS proteins.
Ryo Honda
wiley   +1 more source

3D Video RBD Detection

, 2018
Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by unphysiological skeletal muscle activity during REM sleep and often accompanied by vivid dream enactment.
Taupe, Philip
core   +1 more source

Effects of organic solvents on the depth‐of‐cure determination of conventional and bulk‐fill resin composites

European Journal of Oral Sciences, EarlyView.
Abstract This study investigated the influence of organic solvents on the depth of cure (DOC) of resin composites. Two conventional (Filtek Universal [FU] and Beautifil II [BE]) and two bulk‐fill (Filtek One Bulk Fill [FO] and Beautifil‐Bulk [BB]) composites were evaluated.
Beatriz de Cássia Romano, Frederick Allen Rueggeberg, Jorge Soto‐Montero, Carolina Bosso Andre, Marcelo Giannini   +4 more
wiley   +1 more source