Results 1 to 10 of about 104,598 (50)

Unraveling the role of Major Vault Protein as a novel immune-related biomarker that promotes the proliferation and migration in pancreatic adenocarcinoma

Frontiers in Immunology
BackgroundPancreatic adenocarcinoma (PAAD) is a formidable challenge in oncology research, with a complex pathogenesis that requires to be explored. Major Vault Protein (MVP) is the principal structural component of the vault complex, and its expression ...
Xinyi Wu, Leiyu Hao, Jianghua Lin, Xinyu Guo, Yuping Luo, Chun Li, Chun Li   +6 more
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Association of tumor immune infiltration and prognosis with homologous recombination repair genes mutations in early triple-negative breast cancer

Frontiers in Immunology
The aim of this study was to evaluate the mutation spectrum of homologous recombination repair (HRR) genes and its association with tumor immune infiltration and prognosis in triple-negative breast cancer (TNBC).
Zheng Wang, Anqi Li, Yujie Lu, Mengyuan Han, Miao Ruan, Chaofu Wang, Xiaotian Zhang, Changbin Zhu, Kunwei Shen, Lei Dong, Xiaosong Chen   +10 more
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Long-term cardiovascular inflammation and fibrosis in a murine model of vasculitis induced by Lactobacillus casei cell wall extract

Frontiers in Immunology
BackgroundKawasaki disease (KD), an acute febrile illness and systemic vasculitis, is the leading cause of acquired heart disease in children in industrialized countries. KD leads to the development of coronary artery aneurysms (CAA) in affected children,
Ana Paula Lombardi Pereira, Ana Paula Lombardi Pereira, Ana Paula Lombardi Pereira, Emily Aubuchon, Emily Aubuchon, Debbie P. Moreira, Debbie P. Moreira, Malcolm Lane, Malcolm Lane, Thacyana T. Carvalho, Thacyana T. Carvalho, Thassio R. R. Mesquita, Youngho Lee, Youngho Lee, Timothy R. Crother, Timothy R. Crother, Rebecca A. Porritt, Rebecca A. Porritt, Rebecca A. Porritt, Waldiceu A. Verri, Magali Noval Rivas, Magali Noval Rivas, Moshe Arditi, Moshe Arditi, Moshe Arditi   +24 more
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Multi-omic validation of the cuproptosis-sphingolipid metabolism network: modulating the immune landscape in osteosarcoma

Frontiers in Immunology
BackgroundThe current understanding of the mechanisms by which metal ion metabolism promotes the progression and drug resistance of osteosarcoma remains incomplete.
Qingbiao Li, Jiarui Fang, Kai Liu, Peng Luo, Xiuzhuo Wang   +4 more
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FAM20A: a potential diagnostic biomarker for lung squamous cell carcinoma

Frontiers in Immunology
BackgroundLung squamous cell carcinoma (LUSC) ranks among the carcinomas with the highest incidence and dismal survival rates, suffering from a lack of effective therapeutic strategies.
Yalin Zhang, Qin Sun, Yangbo Liang, Xian Yang, Hailian Wang, Siyuan Song, Yi Wang, Yi Wang, Yong Feng   +8 more
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Rational approach to the prescription of anti-rheumatic drugs in rheumatoid arthritis: a product leaflet-based strategy in Italy

Frontiers in Immunology
The treatment of patients with rheumatoid arthritis (RA) has dramatically changed in the past 30 years. Currently, numerous conventional, biologic, and targeted synthetic DMARDs have been licensed and used following recommendations provided by ...
Carlo Perricone, Andrea Castellucci, Giacomo Cafaro, Santina Calvacchi, Lorenza Bruno, Roberto Dal Pozzolo, Francesco Tromby, Anna Colangelo, Roberto Gerli, Elena Bartoloni   +9 more
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Cathepsin S (CTSS) in IgA nephropathy: an exploratory study on its role as a potential diagnostic biomarker and therapeutic target

Frontiers in Immunology
IntroductionIgA nephropathy (IgAN), a prevalent form of glomerulonephritis globally, exhibits complex pathogenesis. Cathepsins, cysteine proteases within lysosomes, are implicated in various physiological and pathological processes, including renal ...
Shaojie Fu, Meiyan Wu, Yanli Cheng, Yan Guan, Yan Guan, Jinyu Yu, Xueyao Wang, Sensen Su, Hao Wu, Fuzhe Ma, Yan Zou, Yan Zou, Shan Wu, Hongzhao Xu, Zhonggao Xu   +14 more
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Causality of genetically proxied immunophenotypes on cardiovascular diseases: a Mendelian randomization study

Frontiers in Immunology
BackgroundCardiovascular diseases (CVDs) stand as the foremost global cause of mortality, prompting a growing interest in using the potential of immune cells for heart injury treatment.
Xuehan Wang, Huixin Cheng, Meng Feng, Bing Jiang, Chunzhen Ren, Qilin Chen, Xiaodong Zhi, Yingdong Li, Yingdong Li   +8 more
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Clinical features associated with the presence of anti-Ro52 and anti-Ro60 antibodies in Jo-1 antibody-positive anti-synthetase syndrome

Frontiers in Immunology
IntroductionAnti-SSA antibodies target two unrelated proteins, Ro52 (E3 ligase) and Ro60 (RNA binding protein). Previous studies indicate that anti-Ro52 antibodies are frequently associated with various myositis-specific autoantibodies (MSAs)–including ...
Koichi Yamaguchi, Koichi Yamaguchi, Qi Tang, Qi Tang, Paul Poland, Daniel P. Reay, Alyssa Gregory, Rohit Aggarwal, Chester V. Oddis, Dana P. Ascherman   +9 more
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Circadian rhythm disruption-mediated downregulation of Bmal1 exacerbates DSS-induced colitis by impairing intestinal barrier

Frontiers in Immunology
BackgroundCircadian rhythm disruption (CRD) is thought to increase the risk of inflammatory bowel disease. The deletion of Bmal1, a core transcription factor, leads to a complete loss of the circadian rhythm and exacerbates the severity of dextran sodium
Zhongchao Zhang, Wanneng Li, Xu Han, Dean Tian, Wei Yan, Mei Liu, Li Cao   +6 more
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