Results 11 to 20 of about 104,598 (50)

Factors and co-factors influencing clinical manifestations in nsLTPs allergy: between the good and the bad

Frontiers in Allergy, 2023
Non-specific lipid transfer proteins (nsLTPs) are a family of plant pan-allergens that represent the primary cause of food allergies in the Mediterranean area, characterized by a wide range of clinical manifestations, ranging from the total absence of ...
Erminia Ridolo, Erminia Ridolo, Alessandro Barone, Martina Ottoni, Silvia Peveri, Marcello Montagni, Francesca Nicoletta   +6 more
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Elucidating the molecular landscape of tendinitis: the role of inflammasome-related genes and immune interactions

Frontiers in Immunology
Tendinitis, characterized by the inflammation of tendons, poses significant challenges in both diagnosis and treatment due to its multifaceted etiology and complex pathophysiology.
Hongwei Xu, Xiaolang Lu, Yang Yu, Yifei Zhou, Tengfei Qi, Yijing Zheng   +5 more
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NOD2 activation enhances macrophage Fcγ receptor function and may increase the efficacy of antibody therapy

Frontiers in Immunology
IntroductionTherapeutic antibodies have become a major strategy to treat oncologic diseases. For chronic lymphocytic leukemia, antibodies against CD20 are used to target and elicit cytotoxic responses against malignant B cells. However, efficacy is often
Giovanna Merchand-Reyes, Mikayla F. Bull, Ramasamy Santhanam, Maria L. Valencia-Pena, Rakesh A. Murugesan, Aadesh Chordia, Xiaokui-Molly Mo, Frank H. Robledo-Avila, Juan De Dios Ruiz-Rosado, Juan De Dios Ruiz-Rosado, William Edgar Carson, John C. Byrd, Jennifer A. Woyach, Susheela Tridandapani, Jonathan P. Butchar   +14 more
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The impact of cholesteryl ester transfer protein on the progression of cutaneous leishmaniasis

Frontiers in Immunology
IntroductionPathogenesis of cutaneous leishmaniases involves parasite growth, persistent inflammation, and likely participation of lipoproteins (LP). The cholesteryl ester transfer protein (CETP), involved in LP remodeling, has been shown to participate ...
Francisca Elda Batista-Dantas, Christiane Yumi Ozaki, Kelly Gomes Santana, Valéria Sutti Nunes, Bernardina Amorin Uscata, Cinthia Siess-Portugal, Luiza Campos Reis, Luiza Campos Reis, Edite H. Yamashiro-Kanashiro, Wagner Luiz Tafuri, Amaro Nunes Duarte-Neto, Mirian Nacagami Sotto, Hiro Goto, Hiro Goto, Patrícia Miralda Cazita   +14 more
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Therapeutic strategies targeting folate receptor α for ovarian cancer

Frontiers in Immunology, 2023
Epithelial ovarian cancer (EOC) is the deadliest gynecological cancer, and presents a major clinical challenge due to limited treatment options. Folate receptor alpha (FRα), encoded by the FOLR1 gene, is an attractive therapeutically target due to its ...
Jia Mai, Limei Wu, Limei Wu, Ling Yang, Ting Sun, Xiaojuan Liu, Rutie Yin, Yongmei Jiang, Jinke Li, Qintong Li   +9 more
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Translatability of findings from cynomolgus monkey to human suggests a mechanistic role for IL-21 in promoting immunogenicity to an anti-PD-1/IL-21 mutein fusion protein

Frontiers in Immunology
AMG 256 is a bi-specific, heteroimmunoglobulin molecule with an anti-PD-1 antibody domain and a single IL-21 mutein domain on the C-terminus. Nonclinical studies in cynomolgus monkeys revealed that AMG 256 administration led to the development of ...
Mark A. Kroenke, Marta Starcevic Manning, Christina L. Zuch de Zafra, Xinwen Zhang, Kevin D. Cook, Michael Archer, Martijn P. Lolkema, Jin Wang, Sarah Hoofring, Gurleen Saini, Famke Aeffner, Elizabeth Ahern, Elena Garralda Cabanas, Ramaswamy Govindan, Mun Hui, Shalini Gupta, Daniel T. Mytych   +16 more
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Real-world comprehensive genomic and immune profiling reveals distinct age- and sex-based genomic and immune landscapes in tumors of patients with non-small cell lung cancer

Frontiers in Immunology
IntroductionYounger patients with non-small cell lung cancer (NSCLC) (<50 years) represent a significant patient population with distinct clinicopathological features and enriched targetable genomic alterations compared to older patients.
Zachary D. Wallen, Heidi Ko, Mary K. Nesline, Stephanie B. Hastings, Kyle C. Strickland, Kyle C. Strickland, Rebecca A. Previs, Rebecca A. Previs, Shengle Zhang, Sarabjot Pabla, Jeffrey Conroy, Jennifer B. Jackson, Kamal S. Saini, Taylor J. Jensen, Marcia Eisenberg, Brian Caveney, Pratheesh Sathyan, Eric A. Severson, Shakti H. Ramkissoon, Shakti H. Ramkissoon   +19 more
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Impact of maternal Bifidobacterium breve M-16V and scGOS/lcFOS supplementation during pregnancy and lactation on the maternal immune system and milk composition

Frontiers in Immunology
IntroductionMaternal synbiotic supplementation during pregnancy and lactation can significantly influence the immune system. Prebiotics and probiotics have a positive impact on the immune system by preventing or ameliorating among others intestinal ...
Laura Sáez-Fuertes, Laura Sáez-Fuertes, Garyfallia Kapravelou, Blanca Grases-Pintó, Blanca Grases-Pintó, Malen Massot-Cladera, Malen Massot-Cladera, Manuel Bernabeu, Karen Knipping, Johan Garssen, Johan Garssen, Raphaëlle Bourdet-Sicard, Margarida Castell, Margarida Castell, Margarida Castell, Maria José Rodríguez-Lagunas, Maria José Rodríguez-Lagunas, Maria Carmen Collado, Francisco José Pérez-Cano, Francisco José Pérez-Cano   +19 more
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The ΔfbpAΔsapM candidate vaccine derived from Mycobacterium tuberculosis H37Rv is markedly immunogenic in macrophages and induces robust immunity to tuberculosis in mice

Frontiers in Immunology
Tuberculosis (TB) remains a significant global health challenge, with approximately 1.5 million deaths per year. The Bacillus Calmette-Guérin (BCG) vaccine against TB is used in infants but shows variable protection.
Abhishek Mishra, Arshad Khan, Vipul Kumar Singh, Emily Glyde, Sankaralingam Saikolappan, Omar Garnica, Kishore Das, Raja Veerapandian, Subramanian Dhandayuthapani, Chinnaswamy Jagannath   +9 more
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An emerging maestro of immune regulation: how DOT1L orchestrates the harmonies of the immune system

Frontiers in Immunology
The immune system comprises a complex yet tightly regulated network of cells and molecules that play a critical role in protecting the body from infection and disease.
Liam Kealy, Jessica Runting, Daniel Thiele, Sebastian Scheer, Sebastian Scheer   +4 more
doaj   +1 more source