Results 11 to 20 of about 104,598 (50)
Non-specific lipid transfer proteins (nsLTPs) are a family of plant pan-allergens that represent the primary cause of food allergies in the Mediterranean area, characterized by a wide range of clinical manifestations, ranging from the total absence of ...
Erminia Ridolo +6 more
doaj +1 more source
Tendinitis, characterized by the inflammation of tendons, poses significant challenges in both diagnosis and treatment due to its multifaceted etiology and complex pathophysiology.
Hongwei Xu +5 more
doaj +1 more source
IntroductionTherapeutic antibodies have become a major strategy to treat oncologic diseases. For chronic lymphocytic leukemia, antibodies against CD20 are used to target and elicit cytotoxic responses against malignant B cells. However, efficacy is often
Giovanna Merchand-Reyes +14 more
doaj +1 more source
The impact of cholesteryl ester transfer protein on the progression of cutaneous leishmaniasis
IntroductionPathogenesis of cutaneous leishmaniases involves parasite growth, persistent inflammation, and likely participation of lipoproteins (LP). The cholesteryl ester transfer protein (CETP), involved in LP remodeling, has been shown to participate ...
Francisca Elda Batista-Dantas +14 more
doaj +1 more source
Therapeutic strategies targeting folate receptor α for ovarian cancer
Epithelial ovarian cancer (EOC) is the deadliest gynecological cancer, and presents a major clinical challenge due to limited treatment options. Folate receptor alpha (FRα), encoded by the FOLR1 gene, is an attractive therapeutically target due to its ...
Jia Mai +9 more
doaj +1 more source
AMG 256 is a bi-specific, heteroimmunoglobulin molecule with an anti-PD-1 antibody domain and a single IL-21 mutein domain on the C-terminus. Nonclinical studies in cynomolgus monkeys revealed that AMG 256 administration led to the development of ...
Mark A. Kroenke +16 more
doaj +1 more source
IntroductionYounger patients with non-small cell lung cancer (NSCLC) (<50 years) represent a significant patient population with distinct clinicopathological features and enriched targetable genomic alterations compared to older patients.
Zachary D. Wallen +19 more
doaj +1 more source
IntroductionMaternal synbiotic supplementation during pregnancy and lactation can significantly influence the immune system. Prebiotics and probiotics have a positive impact on the immune system by preventing or ameliorating among others intestinal ...
Laura Sáez-Fuertes +19 more
doaj +1 more source
Tuberculosis (TB) remains a significant global health challenge, with approximately 1.5 million deaths per year. The Bacillus Calmette-Guérin (BCG) vaccine against TB is used in infants but shows variable protection.
Abhishek Mishra +9 more
doaj +1 more source
An emerging maestro of immune regulation: how DOT1L orchestrates the harmonies of the immune system
The immune system comprises a complex yet tightly regulated network of cells and molecules that play a critical role in protecting the body from infection and disease.
Liam Kealy +4 more
doaj +1 more source

