Results 11 to 20 of about 106,527 (50)

Mast Cells Drive Systemic Inflammation and Compromised Bone Repair After Trauma

Frontiers in Immunology, 2022
There is evidence that mast cells contribute to inflammation induced by hemorrhagic shock, severe tissue injury or sepsis. Mast cells are highly responsive to alarm signals generated after trauma, and release many inflammatory mediators including ...
Deniz Ragipoglu, Jasmin Bülow, Kristin Hauff, Martin Voss, Melanie Haffner-Luntzer, Anne Dudeck, Anita Ignatius, Verena Fischer   +7 more
doaj   +1 more source

Increased HIV-1 pretreatment drug resistance with consistent clade homogeneity among ART-naive HIV-1 infected individuals in Ethiopia

Retrovirology, 2020
Background The development of pretreatment drug resistance (PDR) is becoming an obstacle to the success of antiretroviral therapy (ART). Besides, data from developing settings including Ethiopia is still limited. Therefore, this study was aimed to assess
Mulugeta Kiros, Dawit Hailu Alemayehu, Eleni Geberekidan, Adane Mihret, Melanie Maier, Woldaregay Erku Abegaz, Andargachew Mulu   +6 more
doaj   +1 more source

Comparison of human B cell activation by TLR7 and TLR9 agonists

BMC Immunology, 2008
Background Human B cells and plasmacytoid dendritic cells (pDC) are the only cells known to express both TLR7 and TLR9. Plasmacytoid dendritic cells are the primary IFN-α producing cells in response to TLR7 and TLR9 agonists.
Neys Lori, Riter Christie L, Vasilakos John P, Hanten John A, Lipson Kenneth E, Alkan Sefik S, Birmachu Woubalem   +6 more
doaj   +1 more source

PRMT6 diminishes HIV-1 Rev binding to and export of viral RNA

Retrovirology, 2006
Background The HIV-1 Rev protein mediates nuclear export of unspliced and partially spliced viral RNA through interaction with the Rev response element (RRE) by means of an arginine rich motif that is similar to the one found in Tat.
Wainberg Mark A, Richard Stéphane, Xie Baode, Invernizzi Cédric F   +3 more
doaj   +1 more source

Predictive value of IgE/IgG₄ antibody ratio in children with egg allergy

Allergy, Asthma & Clinical Immunology, 2012
Background The aim of this study was to investigate the role of specific IgG4 antibodies to hen’s egg white and determine their utility as a marker for the outcome of oral challenge test in children sensitized to hen’s egg Methods The hen’s egg oral food
Okamoto Shindou, Taniuchi Shoichiro, Sudo Kyoko, Hatano Yasuko, Nakano Keiji, Shimo Tomohiko, Kaneko Kazunari   +6 more
doaj   +1 more source

High systemic levels of interleukin-10, interleukin-22 and C-reactive protein in Indian patients are associated with low in vitro replication of HIV-1 subtype C viruses

Retrovirology, 2010
Background HIV-1 subtype C (HIV-1C) accounts for almost 50% of all HIV-1 infections worldwide and predominates in countries with the highest case-loads globally. Functional studies suggest that HIV-1C is unique in its biological properties, and there are
Bala Manju, Nishihara Reiko, Arias Juan F, Ikuta Kazuyoshi   +3 more
doaj   +1 more source

Studies on the Use of Flagellin as an Immunostimulant and Vaccine Adjuvant in Fish Aquaculture

Frontiers in Immunology, 2019
Immunostimulants and vaccines are important for controlling infectious diseases in fish aquaculture. In this study we assess the potential of flagellin to be used for such purposes in rainbow trout (Oncorhynchus mykiss).
Eakapol Wangkahart, Eakapol Wangkahart, Christopher J. Secombes, Tiehui Wang   +3 more
doaj   +1 more source

The innate interferon gamma response of BALB/c and C57BL/6 mice to in vitro Burkholderia pseudomallei infection

BMC Immunology, 2006
Background Burkholderia pseudomallei is the causative agent for melioidosis. For many bacterial infections, cytokine dysregulation is one of the contributing factors to the severe clinical outcomes in the susceptible hosts.
Gan Yunn-Hwen, Koo Ghee
doaj   +1 more source

BCG Vaccination Prevents Reactivation of Latent Lymphatic Murine Tuberculosis Independently of CD4+ T Cells

Frontiers in Immunology, 2019
Tuberculosis (TB) is a major global public health problem causing significant mortality and morbidity. In addition to ~10.4 million cases of active TB annually, it is estimated that about two billion people are latently infected with Mycobacterium ...
Harindra D. Sathkumara, Saparna Pai, Michel de Jesús Aceves-Sánchez, Natkunam Ketheesan, Mario Alberto Flores-Valdez, Andreas Kupz   +5 more
doaj   +1 more source

Mycobacteria-Specific T Cells May Be Expanded From Healthy Donors and Are Near Absent in Primary Immunodeficiency Disorders

Frontiers in Immunology, 2019
Mycobacterial Infections can be severe in patients with T-cell deficiency or phagocyte disorders, and treatment is frequently complicated by antimicrobial resistance.
Shabnum Patel, Shabnum Patel, Haili Lang, Gelina Sani, Alexandra F. Freeman, Jennifer Leiding, Jennifer Leiding, Jennifer Leiding, Patrick J. Hanley, Patrick J. Hanley, Conrad Russell Cruz, Conrad Russell Cruz, Melanie Grant, Yunfei Wang, Benjamin Oshrine, Cindy Palmer, Steven M. Holland, Catherine M. Bollard, Catherine M. Bollard, Catherine M. Bollard, Michael D. Keller, Michael D. Keller   +21 more
doaj   +1 more source