Results 21 to 30 of about 104,598 (50)

Integrated multi-omics and artificial intelligence to explore new neutrophils clusters and potential biomarkers in sepsis with experimental validation

Frontiers in Immunology
BackgroundSepsis, causing serious organ and tissue damage and even death, has not been fully elucidated. Therefore, understanding the key mechanisms underlying sepsis-associated immune responses would lead to more potential therapeutic strategies ...
Peng Xu, Zuo Tao, Cheng Zhang
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A co-culture model to study modulators of tumor immune evasion through scalable arrayed CRISPR-interference screens

Frontiers in Immunology
Cancer cells effectively evade immune surveillance, not only through the well-known PD-1/PD-L1 pathway but also via alternative mechanisms that impair patient response to immune checkpoint inhibitors.
Ramiro Martinez, Ramiro Martinez, Ramiro Martinez, Chiara Finocchiaro, Louis Delhaye, Louis Delhaye, Louis Delhaye, Louis Delhaye, Fien Gysens, Fien Gysens, Fien Gysens, Jasper Anckaert, Jasper Anckaert, Jasper Anckaert, Wim Trypsteen, Wim Trypsteen, Wim Trypsteen, Maarten Versteven, Eva Lion, Sandra Van Lint, Sandra Van Lint, Sandra Van Lint, Karim Vermaelen, Karim Vermaelen, Karim Vermaelen, Eric James de Bony, Eric James de Bony, Eric James de Bony, Pieter Mestdagh, Pieter Mestdagh, Pieter Mestdagh   +30 more
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The vacuolar anti-Pseudomonal activity of neutrophil primary granule peptidyl-arginine deiminase enzymes

Frontiers in Immunology
The role of neutrophils in host defense involves several cell processes including phagocytosis, degranulation of antimicrobial proteins, and the release of neutrophil extracellular traps (NETs).
Rory Baird, Azeez Yusuf, Luke Forde, Kerstin Pohl, Kevin Kavanagh, Fidelma Fitzpatrick, Fidelma Fitzpatrick, Debananda Gogoi, Emer P. Reeves   +8 more
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Construction of an immune‐related prognostic model and potential drugs screening for esophageal cancer based on bioinformatics analyses and network pharmacology

Immunity, Inflammation and Disease
Background Esophageal cancer (ESCA) is a highly invasive malignant tumor with poor prognosis. This study aimed to discover a generalized and high‐sensitivity immune prognostic signature that could stratify ESCA patients and predict their overall survival,
Pengju Qi, Bo Qi, Chengwei Gu, Shuhua Huo, Xinchen Dang, Yuzhen Liu, Baosheng Zhao   +6 more
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Single-cell analysis of matrisome-related genes in breast invasive carcinoma: new avenues for molecular subtyping and risk estimation

Frontiers in Immunology
BackgroundThe incidence of breast cancer remains high and severely affects human health. However, given the heterogeneity of tumor cells, identifying additional characteristics of breast cancer cells is essential for accurate treatment.PurposeThis study ...
Lingzi Su, Zhe Wang, Mengcheng Cai, Qin Wang, Man Wang, Wenxiao Yang, Yabin Gong, Fanfu Fang, Ling Xu   +8 more
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Knowledge framework of intravenous immunoglobulin resistance in the field of Kawasaki disease: A bibliometric analysis (1997−2023)

Immunity, Inflammation and Disease
Background Kawasaki disease (KD) is an autoimmune disease with cardiovascular disease as its main complication, mainly affecting children under 5 years old.
Jiaying Zhang, Hongbiao Huang, Lei Xu, Shuhui Wang, Yang Gao, Wenyu Zhuo, Yan Wang, Yiming Zheng, Xuan Tang, Jiaqi Jiang, Haitao Lv   +10 more
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Differentially expressed proteins and microbial communities of the skin regulate disease resistance to Chinese tongue sole (Cynoglossus semilaevis)

Frontiers in Immunology
Vibriosis, caused by Vibrio, seriously affects the health of fish, shellfish, and shrimps, causing large economic losses. Teleosts are represent the first bony vertebrates with both innate and adaptive immune responses against pathogens.
Lei Wang, Lei Wang, Lei Wang, Min Tian, Min Tian, Min Tian, Min Tian, Songlin Chen, Songlin Chen, Songlin Chen   +9 more
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The development of anticyclic citrullinated peptide (anti‐CCP) antibody following severe COVID‐19

Immunity, Inflammation and Disease
Objectives The dysregulated immune response is one of the cardinal features of severe coronavirus disease 2019 (COVID‐19). This study was conducted to clarify the occurrence of autoantibodies (AABs) associated with systemic autoimmune rheumatic diseases (
Seyed Askar Roghani, Mohammad Dastbaz, Ramin Lotfi, Afsaneh Shamsi, Zahra Abdan, Rezvan Rostampour, Bijan Soleymani, Mohammad Hossein Zamanian, Parviz Soufivand, Mehran Pournazari, Mahdi Taghadosi   +10 more
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The Immunomodulatory effect of exosomes in diabetes: a novel and attractive therapeutic tool in diabetes therapy

Frontiers in Immunology
Exosomes carry proteins, metabolites, nucleic acids and lipids from their parent cell of origin. They are derived from cells through exocytosis, are ingested by target cells, and can transfer biological signals between local or distant cells.
Na Li, Lingli Hu, Jingyang Li, Yang Ye, Zhengyang Bao, Zhice Xu, Daozhen Chen, Jiaqi Tang, Ying Gu, Ying Gu   +9 more
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Scrutiny of chimeric antigen receptor activation by the extracellular domain: experience with single domain antibodies targeting multiple myeloma cells highlights the need for case-by-case optimization

Frontiers in Immunology
IntroductionMultiple myeloma (MM) remains incurable, despite the advent of chimeric antigen receptor (CAR)-T cell therapy. This unfulfilled potential can be attributed to two untackled issues: the lack of suitable CAR targets and formats.
Heleen Hanssens, Heleen Hanssens, Heleen Hanssens, Fien Meeus, Yannick De Vlaeminck, Quentin Lecocq, Janik Puttemans, Pieterjan Debie, Timo W. M. De Groof, Cleo Goyvaerts, Kim De Veirman, Karine Breckpot, Nick Devoogdt   +12 more
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