Results 11 to 20 of about 93,372 (292)
Cells, 2021 In human cells, each rDNA unit consists of the ~13 kb long ribosomal part and ~30 kb long intergenic spacer (IGS). The ribosomal part, transcribed by RNA polymerase I (pol I), includes genes coding for 18S, 5.8S, and 28S RNAs of the ribosomal particles, as well as their four transcribed spacers.
Evgeny Smirnov +2 more
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Variability of Human rDNA [PDF]
Cells, 2021 In human cells, ribosomal DNA (rDNA) is arranged in ten clusters of multiple tandem repeats. Each repeat is usually described as consisting of two parts: the 13 kb long ribosomal part, containing three genes coding for 18S, 5.8S and 28S RNAs of the ribosomal particles, and the 30 kb long intergenic spacer (IGS).
Evgeny Smirnov +4 more
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Calorie restriction reduces rDNA recombination independently of rDNA silencing [PDF]
Aging Cell, 2009 SummaryCalorie restriction (CR) extends lifespan in yeast, worms, flies and mammals, suggesting that it acts via a conserved mechanism. In yeast, activation of the NAD‐dependent histone deacetylase, Sir2, by CR is thought to increase silencing at the ribosomal DNA, thereby reducing the recombination‐induced generation of extrachromosomal rDNA circles ...
Riesen, Michèle, Morgan, Alan
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Autophagy deficiency activates rDNA transcription
Autophagy, 2021 Macroautophagy/autophagy, a highly conserved lysosome-dependent degradation pathway, has been intensively studied in regulating cell metabolism by degradation of intracellular components. In this study, we link autophagy to RNA metabolism by uncovering a regulatory role of autophagy in ribosomal RNA (rRNA) synthesis.
Yinfeng, Xu +9 more
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Allelic inactivation of rDNA loci [PDF]
Genes & Development, 2009 Human cells contain several hundred ribosomal genes (rDNA) that are clustered into nucleolar organizer regions (NORs) on the short arms of five different acrocentric chromosomes. Only ∼50% of the gene copies are actually expressed in somatic cells. Here, we used a new cytological technique to demonstrate that rDNA is regulated allelically in a regional
Sharon, Schlesinger +3 more
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Genomic organization of rat rDNA [PDF]
Nucleic Acids Research, 1983 A detailed restriction map was determined for a 10.9 KB region that contains the initiation site for 45S pre-rRNA and the first 1.7 KB of the 18S rRNA coding region. When the restriction pattern of the cloned rDNA was compared with that of total rat DNA, the rDNA regions of both Sprague-Dawley and BD-9 rats were identical to each other and to that of ...
D M, Chikaraishi +3 more
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Quelling targets the rDNA locus and functions in rDNA copy number control [PDF]
BMC Microbiology, 2009 RNA silencing occurs in a broad range of organisms. Although its ancestral function is probably related to the genome defense mechanism against repetitive selfish elements, it has been found that RNA silencing regulates different cellular processes such as gene expression and chromosomal segregation.
Germano Cecere, COGONI, Carlo
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Helminthologia, 2022 Aphelenchoides bicaudatus associated with grass in South Africa was identified morphologically and molecularly. This population is characterized by a body length of 409 – 529 μm, a stylet length of 9.5 – 13 μm, a post-vulval uterine sac of 45 – 50 μm ...
Shokoohi E., Moyo N. A. G.
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Spatial distribution, host specificity and genetic diversity of Onchobothrium antarcticum in the Southern Ocean [PDF]
Polish Polar Research, 2021 In this work we summarize the current knowledge on the spatial distribution, host specificity and genetic diversity of Onchobothrium antarcticum, an endemic Antarctic cestode.
Ilya I. Gordeev +2 more
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Cytogenetic variability among Bradyporinae species (Orthoptera: Tettigoniidae)
European Journal of Entomology, 2013 Chromosomes of six European species (one with two subspecies) of Orthoptera belonging to the tribes Ephippigerini and Bradyporini were analyzed using C-banding, Ag-NOR, DAPI (AT-rich)/CMA3 (GC-rich) staining and fluorescence in situ hybridization (FISH ...
Elżbieta WARCHAŁOWSKA-ŚLIWA +5 more
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