Results 71 to 80 of about 53,016 (292)
Recombinant viral RdRps can initiate RNA synthesis from circular templates [PDF]
RNA, 2005 The crystal structure of the recombinant hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) revealed extensive interactions between the fingers and the thumb subdomains, resulting in a closed conformation with an established template channel that should specifically accept single-stranded templates. We made circularized RNA templates and found
C T, Ranjith-Kumar, C C, Kao
openaire +2 more sources
FEBS Open Bio, 2014 Identification of viral encoded proteins that interact with RNA-dependent RNA polymerase (RdRp) is an important step towards unraveling the mechanism of replication.
Kunduri Govind +2 more
doaj +1 more source
Hantavirus RdRp Requires a Host Cell Factor for Cap Snatching [PDF]
Journal of Virology, 2019 Humans acquire hantavirus infection by the inhalation of aerosolized excreta of infected rodent hosts. Hantavirus infections cause hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS), with mortality rates of 15% and 50%, respectively (1).
Subbiah, Jeeva +7 more
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The problem of SARS-CoV-2 virus resistance to direct-acting antivirals
Биопрепараты: Профилактика, диагностика, лечениеINTRODUCTION. The high prevalence of mutations in the SARS-CoV-2 genome raises particular concerns about the resistance of the virus to current antiviral therapy, including inhibitors of the main protease, or 3C-like protease (3CLpro), and RNA-dependent ...
E. L. Gasich +6 more
doaj +1 more source
A brief overview of current drug repurposing approaches for COVID-19 management [PDF]
, 2020 This brief overview is intended to shed light on the current drug repositioning (also called drug repurposing) in the therapeutics of the novel coronavirus disease which emerged in 2019 (COVID-19).
Rodrigues, Pedro da Fonseca Soares +1 more
core +2 more sources
Unbiased RNA shotgun metagenomics in social and solitary wild bees detects associations with eukaryote parasites and new viruses [PDF]
, 2016 The diversity of eukaryote organisms and viruses associated with wild bees remains poorly characterized in contrast to the well-documented pathosphere of the western honey bee, Apis mellifera.
Braeckman, Bart +5 more
core +3 more sources
Analysis of RdRp Gene in SARS CoV-2 Variants
International Journal of Research and Review, 2023 SARS CoV-2 was discovered in Wuhan, China, in December 2019 and has since mutated into new variants. One of the genes that mutated in SARS CoV-2 is RNA-dependent RNA polymerase (RdRp), a gene playing roles in viral replication and transcription. This study aimed to determine the variation of the RdRp gene in the SARS CoV-2 variant.
SM Rezvi +2 more
openaire +1 more source
PLoS ONE, 2021 Drug repurposing studies targeting inhibition of RNA dependent RNA polymerase (RdRP) of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) have exhibited the potential effect of small molecules.
Shruti Koulgi +4 more
doaj +1 more source
Advanced Science, 2023 Photoinduced reversible deactivation radical polymerization (photo‐RDRP) or photoinduced controlled/living radical polymerization has emerged as a versatile and powerful technique for preparing functional and advanced polymer materials under mild ...
Zilong Wu, Cyrille Boyer
doaj +1 more source
In situ structures of the segmented genome and RNA polymerase complex inside a dsRNA virus. [PDF]
, 2015 Viruses in the Reoviridae, like the triple-shelled human rotavirus and the single-shelled insect cytoplasmic polyhedrosis virus (CPV), all package a genome of segmented double-stranded RNAs (dsRNAs) inside the viral capsid and carry out endogenous ...
Chang, Winston +5 more
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