Computational evidence on repurposing the anti-influenza drugs baloxavir acid and baloxavir marboxil against COVID-19 [PDF]
arXiv, 2020 The main reasons for the ongoing COVID-19 (coronavirus disease 2019) pandemic are the unavailability of recommended efficacious drugs or vaccines along with the human to human transmission nature of SARS-CoV-2 virus. So, there is urgent need to search appropriate therapeutic approach by repurposing approved drugs.
arxiv
In silico Prediction of Mozenavir as potential drug for SARS-CoV-2 infection via Binding Multiple Drug Targets [PDF]
arXiv, 2021 Since the epidemic began in November 2019, no viable medicine against SARS-CoV-2 has been discovered. The typical medication discovery strategy requires several years of rigorous research and development as well as a significant financial commitment, which is not feasible in the face of the current epidemic.
arxiv
Targeting the RdRp of Emerging RNA Viruses: The Structure-Based Drug Design Challenge [PDF]
Molecules, 2020 The RNA-dependent RNA polymerase (RdRp) is an essential enzyme for the viral replication process, catalyzing the viral RNA synthesis using a metal ion-dependent mechanism. In recent years, RdRp has emerged as an optimal target for the development of antiviral drugs, as demonstrated by recent approvals of sofosbuvir and remdesivir against Hepatitis C ...
Picarazzi F. +4 more
openaire +6 more sources
The problem of SARS-CoV-2 virus resistance to direct-acting antivirals
Биопрепараты: Профилактика, диагностика, лечениеINTRODUCTION. The high prevalence of mutations in the SARS-CoV-2 genome raises particular concerns about the resistance of the virus to current antiviral therapy, including inhibitors of the main protease, or 3C-like protease (3CLpro), and RNA-dependent ...
E. L. Gasich +6 more
doaj +1 more source
Computationally repurposed drugs and natural products against RNA dependent RNA polymerase as potential COVID-19 therapies [PDF]
arXiv, 2020 For fast development of COVID-19, it is only feasible to use drugs (off label use) or approved natural products that are already registered or been assessed for safety in previous human trials. These agents can be quickly assessed in COVID-19 patients, as their safety and pharmacokinetics should already be well understood.
arxiv
RNA‐Based Biopesticides: Pioneering Precision Solutions for Sustainable Aquaculture in China
Animal Research and One Health, EarlyView.The Chinese dragon represents RNA biopesticides, which effectively counteract bacterial, viral, and parasitic threats, safeguarding aquatic life. This method is precise, focusing solely on harmful agents and sparing beneficial aquaculture species. Its innovative nature protects aquatic environments while reducing ecological footprint.
Yiran Huang +7 more
wiley +1 more source
Virtual Screening of Plant Metabolites against Main protease, RNA-dependent RNA polymerase and Spike protein of SARS-CoV-2: Therapeutics option of COVID-19 [PDF]
arXiv, 2020 Covid-19, a serious respiratory complications caused by SARS-CoV-2 has become one of the global threat to human healthcare system. The present study evaluated the possibility of plant originated approved 117 therapeutics against the main protease protein (MPP), RNA-dependent RNA polymerase (RdRp) and spike protein (S) of SARS-CoV-2 including drug ...
arxiv
Total controllability analysis discovers explainable drugs for Covid-19 treatment [PDF]
arXiv, 2022 Network medicine has been pursued for Covid-19 drug repurposing. One such approach adopts structural controllability, a theory for controlling a network (the cell). Motivated to protect the cell from viral infections, we extended this theory to total controllability and introduced a new concept of control hubs.
arxiv
Partial RdRp sequences offer a robust method for Coronavirus subgenus classification [PDF]
, 2020 AbstractThe recent reclassification of theRiboviria, and the introduction of multiple new taxonomic categories including both subfamilies and subgenera for coronaviruses (familyCoronaviridae, subfamilyOrthocoronavirinae) represents a major shift in how official classifications are used to designate specific viral lineages.
Wilkinson, David A +3 more
openaire +2 more sources
ChemCatChem, EarlyView.The challenge of recycling heterogeneous catalysts and reusing them in different reactions was addressed. To this end, salen complexes were anchored on methacrylate insoluble polymers obtained using the Cu(0)‐mediated RDRP method. Their reactivity and recyclability were analyzed in asymmetric ring opening and dynamic kinetic resolution of epoxides ...
Rafaela Bechara +8 more
wiley +1 more source