Results 91 to 100 of about 36,268 (188)

Primers for amplification and sequencing of partial RdRP/VP1 gene.

, 2013
Primers for amplification and sequencing of partial RdRP/VP1 gene.
Huarong Hong (411382), Xuerong Xu (411380), Jianwei Huang (233026), Jianjun Niu (233028), Zhinan Guo (411383), Qinyun Weng (411381), Shuizhen He (363539)   +6 more
core   +1 more source

4′‐ThioRNA Substitution and Sense‐Strand Segmentation for the Design of Functional Fully Modified siRNAs Targeting SARS‐CoV‐2

Chemistry – A European Journal, Volume 32, Issue 40, 27 October 2026.
4′‐ThioRNA was broadly tolerated across multiple positions in SARS‐CoV‐2‐targeting siRNAs, but full 4'‐thio modification of both strands caused a reduction in RNAi activity. Sense‐strand segmentation improved RNAi and antiviral activity, particularly when the nick was located at position 10 from the 5′‐end of the sense strand, thereby unlocking the ...
Yuhei Nogi, Jun Tsukimoto, Noriko Saito‐Tarashima, Takaaki Koma, Masako Nomaguchi, Noriaki Minakawa   +5 more
wiley   +1 more source

The modeled structure of the RNA dependent RNA polymerase of GBV-C Virus suggests a role for motif E in Flaviviridae RNA polymerases

BMC Bioinformatics, 2005
Background The Flaviviridae virus family includes major human and animal pathogens. The RNA dependent RNA polymerase (RdRp) plays a central role in the replication process, and thus is a validated target for antiviral drugs.
Dutartre Hélène, Bussetta Cécile, Ferron François, Canard Bruno   +3 more
doaj   +1 more source

In silico screening for human norovirus antivirals reveals a novel non-nucleoside inhibitor of the viral polymerase

Scientific Reports, 2018
Human norovirus causes approximately 219,000 deaths annually, yet there are currently no antivirals available. A virtual screening of commercially available drug-like compounds (~300,000) was performed on the suramin and PPNDS binding-sites of the ...
Salvatore Ferla, Natalie E. Netzler, Sebastiano Ferla, Sofia Veronese, Daniel Enosi Tuipulotu, Salvatore Guccione, Andrea Brancale, Peter A. White, Marcella Bassetto   +8 more
doaj   +1 more source

Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling.

PLoS Pathogens, 2016
Flaviviruses comprise major emerging pathogens such as dengue virus (DENV) or Zika virus (ZIKV). The flavivirus RNA genome is replicated by the RNA-dependent-RNA polymerase (RdRp) domain of non-structural protein 5 (NS5).
Siew Pheng Lim, Christian Guy Noble, Cheah Chen Seh, Tingjin Sherryl Soh, Abbas El Sahili, Grace Kar Yarn Chan, Julien Lescar, Rishi Arora, Timothy Benson, Shahul Nilar, Ujjini Manjunatha, Kah Fei Wan, Hongping Dong, Xuping Xie, Pei-Yong Shi, Fumiaki Yokokawa   +15 more
doaj   +1 more source

Homology Modeling and Expression of Recombinant NS5-RdRp Based on the Indonesian Local Strain of Dengue Virus for Anti-Dengue Drug Development

Progress in Microbes and Molecular Biology
This study aims to isolate the RNA-dependent RNA polymerase (RdRp) gene of the dengue virus (DENV) isolates from Indonesia, determine the serotype of the local DENV strain through homology modeling, and express the recombinant RdRp protein in ...
Toto Subroto, Ade Rizqi Ridwan Firdaus, Shinta Kusumawardani, Taufik Ramdani Tohari, Theresia Adventina Nababan, Wulan Pertiwi, Muhammad Fadhlillah, Sri Agung Fitri Kusuma, Yaya Rukayadi   +8 more
doaj   +1 more source

Hitting Coronaviruses Where It Hurts: Antiviral Strategies Targeting Viral Proteins

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
Viral proteins represent key vulnerabilities in human coronaviruses (HCoVs). This review outlines inhibitors targeting spike (S), main protease (Mpro), papain‐like protease (PLpro), and RNA‐dependent RNA polymerase (RdRp), mapping chemically diverse strategies that disrupt entry and replication, and provides an integrated view of current candidates ...
Álvaro de la Cruz‐Potenciano, Miguel Maldonado, María‐José Camarasa, Sonia de Castro   +3 more
wiley   +1 more source

Human THP-1 cells expressing a catalytically-active RdRP display highly augmented antiviral defenses.

, 2015
(A) Stable RdRP THP-1 cell lines were generated using lentiviral vectors that co-express GFP-puro with RdRP, RdRPΔcat, or no RdRP (null). (B) Heat map of differentially expressed genes in THP-1 monocytes, presented as fold change (blue = 1-fold induction;
Louisa M. Papke (746703), Laurie J. Zoecklein (833266), Allan J. Bieber (289677), Arthur E. Warrington (156029), William E. Matchett (833268), James H. Morrison (261909), Meghan M. Painter (746702), Jens O. Watzlawik (278985), Kari L. Turkowski (833269), Moses Rodriguez (156032), Eric M. Poeschla (261918), Tommy A. Rinkoski (833267)   +11 more
core   +1 more source

An OTU deubiquitinating enzyme in Eimeria tenella interacts with Eimeria tenella virus RDRP

, 2018
Background Chicken coccidiosis, a disease caused by seven species of Eimeria (Apicomplexa: Coccidia), inflicts severe economic losses on the poultry industry. Eimeria tenella is the one of the most virulent species pathogenic to chickens.
Weirong Wang, Jianhua Li, Pengtao Gong, Pu Wang, Xichen Zhang, Yongxing Ai   +5 more
core   +1 more source

Synthesis rates for Coat and RdRp proteins in Bacteriophage MS2.

, 2023
(A) Temporal dynamics of coat protein and RdRp synthesis from bacteriophage MS2 mRNA in a bacterial cell over 30 minutes. Red dashed line corresponds to the initial synthesis rate of RdRp before coat protein binding to the TR stem-loop (c.f.
Eric C. Dykeman (9922923)
core   +1 more source