Results 91 to 100 of about 29,952 (187)

The Changing Landscape of Hantavirus Infections: A Narrative Review of Epidemiology, Pathogenesis, and Countermeasures

Reviews in Medical Virology, Volume 36, Issue 5, September 2026.
ABSTRACT Hantaviruses are emerging zoonotic pathogens of increasing global public health significance. Their epidemiological landscape is rapidly changing due to ecological disruption, climate variability, urbanisation, and evolving human–animal interfaces.
Francesco De Maria, Francesco Branda, Giancarlo Ceccarelli, Fabio Scarpa, Massimo Ciccozzi, Alessandro Russo   +5 more
wiley   +1 more source

Triple targeting of human IMPDH, SARS-CoV-2 RdRp, and Rhizopus oryzae RdRp: An in silico perspective

Journal of King Saud University - Science, 2023
Abdel-moniem S. Hassan, Abdo A. Elfiky, Alaa M. Elgohary   +2 more
openaire   +1 more source

Genomic characterization of a RdRp-recombinat nebovirus strain with a novel VP1 genotype

Virus Research, 2018
Nebovirus is a new genus within the family Caliciviridae and is a causative agent of calf diarrhea. The limited nebovirus genomic sequences that are currently available has hampered understanding of nebovirus genetic evolution. The aim of the present study was to determine the genomic characterization of strain Bo/LZB-1/17/CH, which was previously ...
Zijing, Guo, Qifu, He, Hua, Yue, Bin, Zhang, Cheng, Tang   +4 more
openaire   +2 more sources

Immunoprotection of grouper by combining recombinant Chlorella sorokiniana carrying the NNV RdRp shRNA/dsRNA with Jingfang granules, epigallocatechin gallate, and ribavirin

Aquaculture Reports
RNA interference (RNAi) is a conserved gene-silencing mechanism in eukaryotes, mediated by double-stranded RNA (dsRNA) or small hairpin RNA (shRNA) to induce specific target gene silencing.
Xiaowen Fei, Peng Hong, Chunmei Xue, SiHang Liu, Dianlong Xu, Juncai Li, Yonghua Hu, Xiaodong Deng   +7 more
doaj   +1 more source

Dengue Virus Molecular Targets and Antiviral Drug Development: Advances, Challenges and Therapeutic Perspectives

ChemistrySelect, Volume 11, Issue 33, 1 September 2026.
This narrative review analyzes DENV molecular targets, including structural proteins (C, prM/M, E), non‐structural components (NS1NS5), and host factors, alongside small‐molecule candidates in preclinical and clinical phases. Owing to high structural conservation, the NS2B‐NS3 protease and NS5 (RdRp/MTase) remain primary drug discovery focuses, while ...
Aryane Lucia da Silva Aguiar De Oliveira, José Arion Da Silva Moura, Pedro César de Souza, Marcelo Arthur Dias da Costa Santana, Matheus Vinicius Guimarães de Melo, Douglas Carvalho Francisco Viana, Marina Galdino Da Rocha Pitta, Isabella Luiza Ralph de Oliveira, Maira Galdino Da Rocha Pitta   +8 more
wiley   +1 more source

Origin and Evolution of RNA-Dependent RNA Polymerase

Frontiers in Genetics, 2017
RNA-dependent RNA polymerases (RdRp) are very ancient enzymes and are essential for all viruses with RNA genomes. We reconstruct the origin and evolution of this polymerase since the initial stages of the origin of life. The origin of the RdRp was traced
Savio T. de Farias, Ariosvaldo P. dos Santos Junior, Thais G. Rêgo, Marco V. José   +3 more
doaj   +1 more source

The Polymorphism of Globin and Virus RdRP and Protein Space

Abstract The divergence of protein sequences, structures, and functions reveals Nature’s exploration of evolutionary possibilities within a given structural fold. Globins are ubiquitous across bacteria, fungi, plants, and animals; RNA-dependent RNA polymerases (RdRPs) are responsible for the replication of RNA viruses.
Dejun Lian, Jie Lian, Qi Dong
openaire   +1 more source

Exploring Erythrina flavonoids as potential SARS-CoV-2 RdRp inhibitors through virtual screening, in silico ADMET evaluation, and molecular dynamics simulation studies

Scientific Reports
The COVID-19 pandemic, caused by SARS-CoV-2, has intensified the search for effective antiviral agents. This study investigates the inhibitory potential of 473 flavonoids from the genus Erythrina against the key enzyme of SARS-CoV-2, RNA-dependent RNA ...
Tati Herlina, Vicki Nishinarizki, Abd. Wahid Rizaldi Akili, Ari Hardianto, Shabarni Gaffar, Muchtaridi Muchtaridi, Jalifah Latip   +6 more
doaj   +1 more source

RNA Dependent RNA Polymerase (RdRP) [PDF]

Science-Business eXchange, 2008
openaire   +2 more sources

Potent halt of SARS-CoV-2 replication using clitocine-induced emergent-viral-RNA editing and disruption. [PDF]

RSC Adv
Rabie AM, El Idrissi IG.
europepmc   +1 more source