Results 91 to 100 of about 29,350 (193)

Nucleobase but not Sugar Fidelity is Maintained in the Sabin I RNA-Dependent RNA Polymerase

Viruses, 2015
The Sabin I poliovirus live, attenuated vaccine strain encodes for four amino acid changes (i.e., D53N, Y73H, K250E, and T362I) in the RNA-dependent RNA polymerase (RdRp).
Xinran Liu, Derek M. Musser, Cheri A. Lee, Xiaorong Yang, Jamie J. Arnold, Craig E. Cameron, David D. Boehr   +6 more
doaj   +1 more source

ProTides for Antiviral Activity Beyond Liver Cells

Chemistry – A European Journal, Volume 32, Issue 21, 1 June 2026.
A strategy for obtaining prodrugs of antiviral nucleotides with broad tissue activity is presented that relies on cycloalkyl or cycloalkylalkyl esters, improving uptake and esterase cleavage, and producing nanomolar inhibitors in kidney, colon, and lung cells.
Felix Goebel, Adrian Humboldt, Heeyoung Kim, Carl J. M. Schölzel, Ralf Bartenschlager, Clemens Richert   +5 more
wiley   +1 more source

Triple targeting of human IMPDH, SARS-CoV-2 RdRp, and Rhizopus oryzae RdRp: An in silico perspective

Journal of King Saud University - Science, 2023
Abdel-moniem S. Hassan, Abdo A. Elfiky, Alaa M. Elgohary   +2 more
openaire   +1 more source

Genomic characterization of a RdRp-recombinat nebovirus strain with a novel VP1 genotype

Virus Research, 2018
Nebovirus is a new genus within the family Caliciviridae and is a causative agent of calf diarrhea. The limited nebovirus genomic sequences that are currently available has hampered understanding of nebovirus genetic evolution. The aim of the present study was to determine the genomic characterization of strain Bo/LZB-1/17/CH, which was previously ...
Zijing, Guo, Qifu, He, Hua, Yue, Bin, Zhang, Cheng, Tang   +4 more
openaire   +2 more sources

Construction and validation of a cell based reporter assay for identifying inhibitors of SARS coronavirus 2 RNA dependent RNA polymerase activity

Scientific Reports
Targeting RNA-dependent RNA polymerase (RdRp), a highly conserved enzyme essential for SARS coronavirus 2 (SARS-CoV-2) replication and transcription, represents a promising antiviral strategy due to its lower mutation rate than structural proteins such ...
Eunjeong Kang, Haelim Yoon, Junho Lee, JinAh Lee, Seungtaek Kim, Inseong Jo, Soo Bong Han, Dae Gwin Jeong, Sayeon Cho   +8 more
doaj   +1 more source

Origin and Evolution of RNA-Dependent RNA Polymerase

Frontiers in Genetics, 2017
RNA-dependent RNA polymerases (RdRp) are very ancient enzymes and are essential for all viruses with RNA genomes. We reconstruct the origin and evolution of this polymerase since the initial stages of the origin of life. The origin of the RdRp was traced
Savio T. de Farias, Ariosvaldo P. dos Santos Junior, Thais G. Rêgo, Marco V. José   +3 more
doaj   +1 more source

Tautomerism‐Governed Two‐Proton‐Coupled Electron Transfer in the Oxidation of a Molnupiravir by Electrogenerated Superoxide Radical Anion in N,N‐Dimethylformamide

ChemistrySelect, Volume 11, Issue 21, 4 June 2026.
Tautomerization‐assisted oxidation of molnupiravir by superoxide (O2•−) in aprotic DMF. The thermodynamically favored oxime tautomer of the N4‐hydroxycytosine moiety forms a prereactive complex (PRC) with O2•− through hydrogen‐bonding interactions.
Tatsushi Nakayama, Kaisei Hara
wiley   +1 more source

Immunoprotection of grouper by combining recombinant Chlorella sorokiniana carrying the NNV RdRp shRNA/dsRNA with Jingfang granules, epigallocatechin gallate, and ribavirin

Aquaculture Reports
RNA interference (RNAi) is a conserved gene-silencing mechanism in eukaryotes, mediated by double-stranded RNA (dsRNA) or small hairpin RNA (shRNA) to induce specific target gene silencing.
Xiaowen Fei, Peng Hong, Chunmei Xue, SiHang Liu, Dianlong Xu, Juncai Li, Yonghua Hu, Xiaodong Deng   +7 more
doaj   +1 more source

The evolving role of structural biology in pharma: integration of X‐ray crystallography, cryo‐electron microscopy and beyond

Acta Crystallographica Section D, Volume 82, Issue 6, Page 587-602, June 2026.
This review describes how an integrated structural biology platform at Merck Sharp & Dohme LLC, Rahway, New Jersey, USA, combining X‐ray crystallography, cryo‐EM, MicroED and cryo‐ET, enables seamless three‐dimensional insights from molecular to cellular length scales.
Jill E. Chrencik, Hua-Poo Su, Yacob Gomez Llorente, Rachel L. Palte, Daniel J. Klein, Robert P. Hayes, Sadie P. Antine, Guilermo A. Asmar-Rovira, Nicole Bertoletti, Noel J. Byrne, Brittany L. Carroll, Ciro D. Cordeiro, Kaylynn Curfman, James Dutko, Michael J. Eddins, Thierry Fischmann, Barani Govindarajan, Corey W. Hecksel, Thu Ho, Kaspar Hollenstein, Mee Ra Hong, Alan Hruza, Andrii Ishchenko, Maru Jaime-Garza, Matt J. Jaremko, Hayley L. Knox, James Kostas, Harini Krishnamurthy, Ioannis Manolaridis, Cameron L. Noland, Andrea T. Partridge, Sangita B. Patel, Paul Reichert, John C. Reid, Catarina Felisberto-Rodrigues, Chitra A. Shintre, Jennifer M. Shipman, Elakkiya Tamilselvan, Morgan E. Walker, Susanne N. Walker, Renjing Wang, Katharine M. Wright, Tien-Jui Yen, Byung-Kuk Yoo, Sandra B. Gabelli   +44 more
wiley   +1 more source

Re‐emergent snakehead rhabdovirus in Thailand after two decades: Isolation and genomic characterization

Journal of the World Aquaculture Society, Volume 57, Issue 3, June 2026.
Abstract Snakehead rhabdovirus (SHRV) is a novirhabdovirus associated with disease outbreaks in warm‐water fish in Southeast Asia, including striped snakehead (Channa striata), but recent information on SHRV in Thai snakehead aquaculture remains limited.
Kitipong Angsujinda, Nabhasbhichayabha Daewang, Nopadon Pirarat, Timothy J. Mahony, Wanchai Assavalapsakul   +4 more
wiley   +1 more source