Results 101 to 110 of about 36,268 (188)

Nucleobase but not Sugar Fidelity is Maintained in the Sabin I RNA-Dependent RNA Polymerase

Viruses, 2015
The Sabin I poliovirus live, attenuated vaccine strain encodes for four amino acid changes (i.e., D53N, Y73H, K250E, and T362I) in the RNA-dependent RNA polymerase (RdRp).
Xinran Liu, Derek M. Musser, Cheri A. Lee, Xiaorong Yang, Jamie J. Arnold, Craig E. Cameron, David D. Boehr   +6 more
doaj   +1 more source

Construction and validation of a cell based reporter assay for identifying inhibitors of SARS coronavirus 2 RNA dependent RNA polymerase activity

Scientific Reports
Targeting RNA-dependent RNA polymerase (RdRp), a highly conserved enzyme essential for SARS coronavirus 2 (SARS-CoV-2) replication and transcription, represents a promising antiviral strategy due to its lower mutation rate than structural proteins such ...
Eunjeong Kang, Haelim Yoon, Junho Lee, JinAh Lee, Seungtaek Kim, Inseong Jo, Soo Bong Han, Dae Gwin Jeong, Sayeon Cho   +8 more
doaj   +1 more source

Flavivirus RNA-Dependent RNA Polymerase Interacts with Genome UTRs and Viral Proteins to Facilitate Flavivirus RNA Replication

Viruses, 2019
Flaviviruses, most of which are emerging and re-emerging human pathogens and significant public health concerns worldwide, are positive-sense RNA viruses. Flavivirus replication occurs on the ER and is regulated by many mechanisms and factors. NS5, which
YanPing Duan, Miao Zeng, Bowen Jiang, Wei Zhang, Mingshu Wang, Renyong Jia, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Qiao Yang, Ying Wu, ShaQiu Zhang, YunYa Liu, Ling Zhang, YanLing Yu, Leichang Pan, Shun Chen, Anchun Cheng   +17 more
doaj   +1 more source

Molecular placement of rutin in MNV-1 RdRp

, 2014
Rutin conformation in MNV-1 RdRp (3UPF) after 50ns molecular dynamic simulation starting from the XP pose.
Nicolas Cheron (654641)
core   +1 more source

Immunoprotection of grouper by combining recombinant Chlorella sorokiniana carrying the NNV RdRp shRNA/dsRNA with Jingfang granules, epigallocatechin gallate, and ribavirin

Aquaculture Reports
RNA interference (RNAi) is a conserved gene-silencing mechanism in eukaryotes, mediated by double-stranded RNA (dsRNA) or small hairpin RNA (shRNA) to induce specific target gene silencing.
Xiaowen Fei, Peng Hong, Chunmei Xue, SiHang Liu, Dianlong Xu, Juncai Li, Yonghua Hu, Xiaodong Deng   +7 more
doaj   +1 more source

Origin and Evolution of RNA-Dependent RNA Polymerase

Frontiers in Genetics, 2017
RNA-dependent RNA polymerases (RdRp) are very ancient enzymes and are essential for all viruses with RNA genomes. We reconstruct the origin and evolution of this polymerase since the initial stages of the origin of life. The origin of the RdRp was traced
Savio T. de Farias, Ariosvaldo P. dos Santos Junior, Thais G. Rêgo, Marco V. José   +3 more
doaj   +1 more source

Effect of RdRP-mediated amplification.

, 2013
Each graph shows restoration versus time for numerical simulations of recursive RNAi experiments targeting Dicer. (A) gamma = 1. (B) gamma = 200. Within each graph, results for different values of the amplification efficacy parameter theta are given ...
Wallace F. Marshall (376629)
core   +1 more source

The structure of the hPBV RdRP.

, 2016
(a) Ribbon diagram of the hPBV RdRP crystal structure. The N- and C-terminal domains are colored in yellow and magenta, respectively. The core polymerase domain is shown in three different colors with the fingers in blue, the palm in red, and the thumb ...
Outi L. Lyytinen (3174675), Yukimatsu Toh (3174678), Yusong R. Guo (3174681), Yizhi J. Tao (3174687), Minna M. Poranen (115053), Aaron M. Collier (3174684)   +5 more
core   +1 more source

In silico study of RNA polymerase inhibitor drugs for Rift Valley fever virus using RdRp protein as the target

Context: Rift Valley fever (RVF) is a disease caused by the RVF virus (RVFV), concentrated mostly in Africa. The virus, usually found in animals, can infect humans through contact with infected animals or mosquito vectors. No established treatment exists,
Mukti Subagja, Juan Lorell, Theophanie Scholastica Tanzil, Arli Aditya Parikesit, Nicolaas Raditya Putra Gautama   +4 more
core   +1 more source

Eribulin inhibits RdRP activity but not telomerase activity of hTERT.

, 2014
(A) RdRP activity of hTERT immune complexes prepared from HeLa cells arrested in the mitotic phase was assayed without or with 10 and 50 µM eribulin. (B) Telomerase activity in HeLa cell extracts was assayed without or with 10 and 50 µM eribulin.
Masayuki Yoshida (220371), Yoshiko Maida (655364), Kenkichi Masutomi (270401), Mami Yasukawa (655365), Satoko Yamaguchi (655363), Tomoyasu Kato (655366)   +5 more
core   +1 more source