Results 101 to 110 of about 29,350 (193)

The Pathogenesis‐Related Protein 4b Induced by Rice Stripe Virus Enhances Host's Antiviral Defence

Molecular Plant Pathology, Volume 27, Issue 6, June 2026.
OsPR4b is induced by RSV to inhibit viral infection via regulating RNA metabolism and cell wall reinforcement, while its knockdown modulates NAC/MYB/ERF/WRKY family genes and enhances viral accumulation. ABSTRACT Rice stripe virus (RSV) causes rice stripe disease, which poses a serious threat to rice production.
Binhao Gao, Long Ma, Huiyuan Zhang, Sinan Chen, Qiao Wang, Mingjun Li, Ling Qing, Gentu Wu   +7 more
wiley   +1 more source

Streamlined Synthesis and Structure–Activity Relationship Analysis of 2‐Amidothiophene‐3‐Carboxamides Targeting Influenza Polymerase PA‐PB1 Heterodimerization

ChemMedChem, Volume 21, Issue 10, 27 May 2026.
Development of a three‐step synthesis and replacement of the cycloheptyl moiety in cycloheptathiophene‐3‐carboxamide derivatives revealed how thiophene C‐5 substitutions modulate PA–PB1 inhibition, antiviral potency, and water solubility. The phenyl analog 9 delivered sub‐µM potency across multiple IV strains, while the methyl analog 5 achieved the ...
Tommaso Felicetti, Alessia Zago, Andrea Astolfi, Giuseppe Manfroni, Stefano Sabatini, Maria Letizia Barreca, Oriana Tabarrini, Arianna Loregian, Serena Massari   +8 more
wiley   +1 more source

Exploring Erythrina flavonoids as potential SARS-CoV-2 RdRp inhibitors through virtual screening, in silico ADMET evaluation, and molecular dynamics simulation studies

Scientific Reports
The COVID-19 pandemic, caused by SARS-CoV-2, has intensified the search for effective antiviral agents. This study investigates the inhibitory potential of 473 flavonoids from the genus Erythrina against the key enzyme of SARS-CoV-2, RNA-dependent RNA ...
Tati Herlina, Vicki Nishinarizki, Abd. Wahid Rizaldi Akili, Ari Hardianto, Shabarni Gaffar, Muchtaridi Muchtaridi, Jalifah Latip   +6 more
doaj   +1 more source

The Polymorphism of Globin and Virus RdRP and Protein Space

Abstract The divergence of protein sequences, structures, and functions reveals Nature’s exploration of evolutionary possibilities within a given structural fold. Globins are ubiquitous across bacteria, fungi, plants, and animals; RNA-dependent RNA polymerases (RdRPs) are responsible for the replication of RNA viruses.
Dejun Lian, Jie Lian, Qi Dong
openaire   +1 more source

RNA Dependent RNA Polymerase (RdRP) [PDF]

Science-Business eXchange, 2008
openaire   +2 more sources

Wyeomyia confusa Lispivirus (WcLispV-SP): a novel neotropical mosquito virus in the Lispiviridae family. [PDF]

Arch Virol
Guimarães LO, Couto RDS, Reginato SL, Mucci LF, Pandey RP, de Camargo-Neves VLF, da Costa AC, Kirchgatter K, Leal E.   +8 more
europepmc   +1 more source

Comprehensive hallmark gene sequence, genomic and structural analysis clarifies new and established taxa within the <i>Picornavirales</i>. [PDF]

Virus Evol
Mayne R, Smith DB, Brown K, Chen YP, Firth AE, Katayama K, Knowles NJ, Simmonds P.   +7 more
europepmc   +1 more source

Near-complete genome sequence of a rhabdovirus identified from the rice pest <i>Stenchaetothrips biformis</i>. [PDF]

Microbiol Resour Announc
Ma L-L, Li J-M, Huang H-J.
europepmc   +1 more source

High-Throughput Kinetic Screening of UV and Visible Light-Induced Copper-RDRP in Continuous Flow Using Inline Benchtop NMR Analysis. [PDF]

JACS Au
Hall MD, Zhang B, Liarou E, Junkers T, Haddleton D.   +4 more
europepmc   +1 more source

Revealing deep evolutionary relationships between RNA viruses using predicted structural models of viral RNA polymerases. [PDF]

Mol Biol Evol
Mönttinen HAM, Ravantti JJ, Mayne R, Simmonds P, Poranen MM.   +4 more
europepmc   +1 more source