Results 81 to 90 of about 29,350 (193)
BMC Bioinformatics, 2005 Background The Flaviviridae virus family includes major human and animal pathogens. The RNA dependent RNA polymerase (RdRp) plays a central role in the replication process, and thus is a validated target for antiviral drugs.
Dutartre Hélène +3 more
doaj +1 more source
Advanced Science, Volume 13, Issue 33, 15 June 2026.A semiconductor‐fabricated nanowell biosensor enables rapid, scalable, and highly reproducible detection of SARS‐CoV‐2 antigens from nasal swabs within ∼10 minutes. Clinical validation in 249 retrospective and 243 prospective patient samples demonstrates high sensitivity and specificity, minimal cross‐reactivity, and robust batch‐to‐batch ...
Yoo Min Park +11 more
wiley +1 more source
Scientific Reports, 2018 Human norovirus causes approximately 219,000 deaths annually, yet there are currently no antivirals available. A virtual screening of commercially available drug-like compounds (~300,000) was performed on the suramin and PPNDS binding-sites of the ...
Salvatore Ferla +8 more
doaj +1 more source
PLoS Pathogens, 2016 Flaviviruses comprise major emerging pathogens such as dengue virus (DENV) or Zika virus (ZIKV). The flavivirus RNA genome is replicated by the RNA-dependent-RNA polymerase (RdRp) domain of non-structural protein 5 (NS5).
Siew Pheng Lim +15 more
doaj +1 more source
Aquaculture, Fish and Fisheries, Volume 6, Issue 3, June 2026.ABSTRACT The rapid expansion of cage culture for Nile tilapia (Oreochromis niloticus) in Lake Victoria is central to food security and profitable development in East Africa. Nevertheless, viral conditions affect the sustainability of this sector, with significant imbalances in livelihood, trade and aquaculture adaptability.
Richard S. Komba, Chacha J. Mwita
wiley +1 more source
Photolyzable Polymer Brushes: Subtractive 3D Structuring of Surfaces Using Water and Light
Angewandte Chemie, Volume 138, Issue 22, 25 May 2026.Facile structuring of polymer brushes is achieved by flipping the process from controlled growth to controlled brush photolysis. Using surface‐initiated radical ring‐opening polymerization of cyclic monomers with photocleavable cyclobutane rings, photodegradable targets are embedded into the polymer chains. The enabled continuous subtractive patterning
Henrik Kalmer +11 more
wiley +2 more sources
Progress in Microbes and Molecular BiologyThis study aims to isolate the RNA-dependent RNA polymerase (RdRp) gene of the dengue virus (DENV) isolates from Indonesia, determine the serotype of the local DENV strain through homology modeling, and express the recombinant RdRp protein in ...
Toto Subroto +8 more
doaj +1 more source
Aquaculture, Fish and Fisheries, Volume 6, Issue 3, June 2026.ABSTRACT Aquaculture has overtaken capture fisheries as the main source of aquatic animal protein, marking a critical step in global food security. Yet, rapid intensification faces major challenges, including disease outbreaks, environmental degradation, and dependence on wild‐caught fish for feed.
Suvadip Ghara +8 more
wiley +1 more source
Viruses, 2019 Flaviviruses, most of which are emerging and re-emerging human pathogens and significant public health concerns worldwide, are positive-sense RNA viruses. Flavivirus replication occurs on the ER and is regulated by many mechanisms and factors. NS5, which
YanPing Duan +17 more
doaj +1 more source
ChemistryEurope, Volume 4, Issue 6, June 2026.Combination is the dominant bimolecular termination mode of the diffused acrylate radical carbomethoxyethyl (MeCH•(COOMe), or RH•), but its generation by Br‐atom abstraction from methyl 2‐bromopropionate (RH‐Br) with a variety of metalloradicals (Mt•) opens a competitive pathway via the {RH•, Mt•} caged pair, leading to 100% disproportionation ...
Laurianne Forget +3 more
wiley +1 more source