Results 71 to 80 of about 36,268 (188)
A computational approach to drug repurposing against SARS-CoV-2 RNA dependent RNA polymerase (RdRp)
, 2020 The spread of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) caused a worldwide outbreak of coronavirus disease 19 (COVID-19), which rapidly evolved as a global concern.
Memo, Maurizio +11 more
core +1 more source
Insight Into the Interaction Between RNA Polymerase and VPg for Murine Norovirus Replication
Frontiers in Microbiology, 2018 Norovirus (NoV) is a leading cause of epidemic acute non-bacterial gastroenteritis, and replicates through virion protein genome-linked (VPg)-primed or de novo RNA synthesis by RNA-dependent RNA polymerase (RdRp).
Ji-Hye Lee +12 more
doaj +1 more source
Nature Communications, 2020 During translocation by viral RNA-dependent RNA polymerases (RdRP), the template-product RNA duplex moves in an asymmetric manner. Here the authors describe several crystal structures of RdRP translocations intermediates that, along with enzymological ...
Meihua Wang +5 more
doaj +1 more source
The Canadian Journal of Chemical Engineering, EarlyView.Abstract Organic electronics have emerged as a key class of functional materials for organic light‐emitting diodes (OLEDs), organic photovoltaics (OPVs), organic field‐effect transistors (OFETs), sensors, and printed electronics. However, commercialization remains dependent on the ability to reproducibly synthesize and manufacture high‐performance ...
Marko D. Saban, Benoît H. Lessard
wiley +1 more source
Rapid induction of antiviral ISG mRNAs following RdRP expression in human lung epithelial cells.
, 2015 (A) DOX-inducible RdRP A549 cell lines were generated using lentiviral vectors that inducibly co-express RdRP or RdRPΔcat and resistance to puromycin.
Louisa M. Papke (746703) +11 more
core +1 more source
PLoS ONE, 2021 To stop the COVID-19 pandemic due to the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which caused more than 2.5 million deaths to date, new antiviral molecules are urgently needed.
Clément Madru +6 more
doaj +1 more source
Macromolecular Rapid Communications, EarlyView.A sequential one‐pot photo‐iniferter RAFT method greatly simplifies the synthesis of PAN‐based block copolymers, offering quick access to hierarchically porous, N‐doped carbon membranes. This scalable and reliable process allows for easy fabrication of functional materials important for carbon capture applications.
Björn Schmidt +9 more
wiley +1 more source
G-3 RdRp, X and Helicase associate with each other in Huh7 cells.
, 2016 (A) CoIP and western of Huh7 cell extract transiently expressing g-3 RdRp and X, immunoprecipitated and revealed using indicated antibodies. (B) CoIP and western of Huh7 cell extract transiently expressing g-3 Helicase and X, immunoprecipitated and ...
Shalimar (538335) +9 more
core +1 more source
, 2023 COVID-19, a disease caused by SARS-CoV-2, has caused a huge loss of human life, and the number of deaths is still continuing. Despite the lack of repurposed drugs and vaccines, the search for potential small molecules to inhibit SARS-CoV-2 is in demand ...
Sarfaraz Ahmed +5 more
core +1 more source
New Plant Protection, EarlyView.Despite 17 years of development, the effectiveness of nanocarrier‐delivered RNAi pesticide (NDRP) for agricultural biological control remains limited. The successful development of effective NDRP development requires the coordinated optimization of target gene selection and nanocarrier properties, including RNA dosage, multi‐gene targeting, protection ...
Shi Dong Wang +4 more
wiley +1 more source