Results 71 to 80 of about 46,334 (221)

Role of RNA Interference (RNAi) in the Moss Physcomitrella patens [PDF]

, 2013
RNA interference (RNAi) is a mechanism that regulates genes by either transcriptional (TGS) or posttranscriptional gene silencing (PTGS), required for genome maintenance and proper development of an organism.
Arif, Muhammad Asif, Frank, Wolfgang, Khraiwesh, Basel   +2 more
core   +3 more sources

A Structure-Function Diversity Survey of the RNA-Dependent RNA Polymerases From the Positive-Strand RNA Viruses

Frontiers in Microbiology, 2019
The RNA-dependent RNA polymerases (RdRPs) encoded by the RNA viruses are a unique class of nucleic acid polymerases. Each viral RdRP contains a 500–600 residue catalytic module with palm, fingers, and thumb domains forming an encircled human right hand ...
Hengxia Jia, Hengxia Jia, Peng Gong
doaj   +1 more source

Identification of novel mutations in RNA-dependent RNA polymerases of SARS-CoV-2 and their implications on its protein structure [PDF]

PeerJ, 2020
The rapid development of the SARS-CoV-2 mediated COVID-19 pandemic has been the cause of significant health concern, highlighting the immediate need for effective antivirals. SARS-CoV-2 is an RNA virus that has an inherently high mutation rate.
Gyanendra Bahadur Chand, Atanu Banerjee, Gajendra Kumar Azad   +2 more
doaj   +2 more sources

Mass‐Produced and High‐Performance Nanowell Biosensor Fabricated via Semiconductor Manufacturing for Rapid and Accurate COVID‐19 Diagnosis in the Clinical Field

Advanced Science, EarlyView.
A semiconductor‐fabricated nanowell biosensor enables rapid, scalable, and highly reproducible detection of SARS‐CoV‐2 antigens from nasal swabs within ∼10 minutes. Clinical validation in 249 retrospective and 243 prospective patient samples demonstrates high sensitivity and specificity, minimal cross‐reactivity, and robust batch‐to‐batch ...
Yoo Min Park, Zahra Rezaei, Nam Ho Bae, Donggee Rho, Da‐Seul Kim, EunYoung Go, YoungTae Seo, Seok Jae Lee, Won Chan Seo, Luke P. Lee, HeaYeon Lee, Su Ryon Shin   +11 more
wiley   +1 more source

Mutations in RNA‐dependent RNA polymerase could be major cause of high pandemic potential of SARS‐CoV‐2: An in‐silico study

Indonesian Journal of Biotechnology
Human coronaviruses (HCoVs) are responsible for mild common cold to severe pneumonia‐like symptoms in infected individuals. The first HCoV was HCoV‐229E, discovered in 1962 in the US, which causes moderate symptoms.
Bhawna Sharma, Bennet Angel, Annette Angel, Vinod Joshi, Shareef Mohammed Buvvaji, Neha Singh, Khushbu Kumari, Aarya Chitransh, Poorna Khaneja, Devendra Kumar   +9 more
doaj   +1 more source

Development of a method for evaluating the mRNA transcription activity of influenza virus RNA-dependent RNA polymerase through real-time reverse transcription polymerase chain reaction

Virology Journal, 2021
Background The development of an influenza RNA-dependent RNA polymerase (RdRp) inhibitor is required; therefore, a method for evaluating the activity of influenza RdRp needs to be developed.
Yuka Horio, Mototada Shichiri, Yuji Isegawa   +2 more
doaj   +1 more source

In situ structures of the segmented genome and RNA polymerase complex inside a dsRNA virus. [PDF]

, 2015
Viruses in the Reoviridae, like the triple-shelled human rotavirus and the single-shelled insect cytoplasmic polyhedrosis virus (CPV), all package a genome of segmented double-stranded RNAs (dsRNAs) inside the viral capsid and carry out endogenous ...
Chang, Winston, Ding, Ke, Sun, Jingchen, Yu, Xuekui, Zhang, Xing, Zhou, Z Hong   +5 more
core  

ICTV Virus Taxonomy Profile: Chrysoviridae [PDF]

, 2018
The Chrysoviridae is a family of small, isometric, non-enveloped viruses (40 nm in diameter) with segmented dsRNA genomes (typically four segments). The genome segments are individually encapsidated and together comprise 11.5–12.8 kbp.
Bradley I. Hillman, Dae-Hyun Kim, Daohong Jiang, Ghabrial, Hiromitsu Moriyama, José R. Castón, Robert H. A. Coutts, Said A. Ghabrial   +7 more
core   +2 more sources

RdRp mutations are associated with SARS-CoV-2 genome evolution

PeerJ, 2020
AbstractCOVID-19, caused by the novel SARS-CoV-2 virus, started in China in late 2019, and soon became a global pandemic. With the help of thousands of viral genome sequences that have been accumulating, it has become possible to track the evolution of viral genome over time as it spread across the world.
Doğa Eskier, Gökhan Karakülah, Aslı Suner, Yavuz Oktay   +3 more
openaire   +4 more sources

Evaluation of the Antiviral Characteristics of Tetragonula sapiens Propolis from Indonesia Using In Vitro and In Silico Methods

International Journal of Technology
The previous outbreaks of syndrome coronavirus 2 (SARS-CoV-2) are indications of the need for effective antiviral agents to mitigate disease severity and future outbreaks. In this context, natural products such as propolis have gained attention for their
Safira Candra Asih, Mohammad Nasikin, Jim-Tong Horng, Hui-Ping Tsai, Shan-Ko Tsai, Cheng-Hsun Chiu, Diah Kartika Pratami, Abdul Mun’im, Muhamad Sahlan   +8 more
doaj   +1 more source