Results 71 to 80 of about 29,952 (187)

Polymeric Polyaldehyde Approach to Develop Robust Dynamic Covalent Adaptive Polyimine Networks

Macromolecular Rapid Communications, EarlyView.
A versatile approach exploring the synthesis of polymeric polyaldehydes with a polyacrylate backbone bearing pendant aldehyde groups to develop dynamic polyacrylate‐polyimine hybrid materials capable of the built‐in ability for extended operation and enhanced reliability. ABSTRACT Polyimine‐based covalent adaptive networks crosslinked with Schiff bases
Subrata Dolui, Sofia Nieves Casillas‐Popova, Seung Ki Lee, Sun Ju Kim, Hira Rasheed, Zhibin Ye, Minsoo P. Kim, Hyun Wook Jung, Jung Kwon Oh   +8 more
wiley   +1 more source

Enterovirus infections in children

Pediatric Investigation, EarlyView.
Enteroviruses (EVs) are major pathogens causing a wide spectrum of diseases in children worldwide. This review summarizes the epidemiology, virology, viral replication, and virus‐host interactions of EVs. It also highlights current advances in clinical diagnosis, antiviral therapies, and vaccine development, providing insights into future strategies ...
Xiangpeng Chen, Lingyun Guo, Xiaobo Lei, Linqing Zhao, Mingyan Hei, Jun Shen, Ju Yin, Fei Li, Jikui Deng, Gang Liu, Yong Zhang, Zhengde Xie   +11 more
wiley   +1 more source

Development and deployment of a risk assessment index as a decision‐support tool for managing whitefly‐transmitted viruses affecting squash

Pest Management Science, EarlyView.
A data‐driven framework identified planting date and row cover as dominant drivers of whitefly‐transmitted virus complex (WTVC) risk in squash. Integration into the SquashRx mobile application enables real‐time risk assessment and supports improved decision‐making for integrated pest management.
Clarence B Codod, Anoop A Malik, Alton N Sparks Jr., Andre Luiz Biscaia Ribeiro da Silva, Paul M Severns, Joara Candian, Rajagopalbabu Srinivasan, Ty Torrance, Robert C Kemerait Jr., Bhabesh Dutta   +9 more
wiley   +1 more source

Interference of small compounds and Mg2+ with dsRNA-binding fluorophores compromises the identification of SARS-CoV-2 RdRp inhibitors

Scientific Reports
The COVID-19 pandemic highlighted the need for the rapid development of antiviral therapies. Viral RNA-dependent RNA polymerases (RdRp) are promising targets, and numerous virtual screenings for potential inhibitors were conducted without validation of ...
Susana Llanos, Bruno Di Geronimo, Ester Casajús, Elena Blanco-Romero, Rafael Fernández-Leiro, Juan Méndez   +5 more
doaj   +1 more source

Iflaviruses in arthropods: when small is mighty

Insect Science, EarlyView.
Many arthropod species harbor iflaviruses, which often cause covert (asymptomatic) infections, but may still affect host fitness. We review the impact of iflaviruses on arthropod fitness, immunity, behaviour as well as the iflavirus’ host range, transmission, tissue tropism and the interactions with other microorganisms within arthropods.
Annamaria Mattia, Hannah‐Isadora Huditz, Monique M. van Oers, Vera I.D. Ros   +3 more
wiley   +1 more source

NeoRdRp2 with improved seed data, annotations, and scoring

Frontiers in Virology
RNA-dependent RNA polymerase (RdRp) is a marker gene for RNA viruses; thus, it is widely used to identify RNA viruses from metatranscriptome data. However, because of the high diversity of RdRp domains, it remains difficult to identify RNA viruses using ...
Shoichi Sakaguchi, Takashi Nakano, So Nakagawa, So Nakagawa, So Nakagawa   +4 more
doaj   +1 more source

Route of Allergen Immunotherapy: A Global Look Into Physicians' Motivations

Allergy, EarlyView.
Little is known about the factors driving AIT prescription in clinical practice, including the level of personalization from patient to patient. Patient‐centred factors theoretically would favour SLIT prescription. Doctors’ knowledge, training, and country influence the final decision on the route.
Carmen Vidal, Davide P. Caimmi, Pablo Rodriguez del Rio, Óscar Lado‐Baleato, Francisco Gude, Pilar Rico‐Nieto, Thomas B. Casale, Jorge A. Aguilar, Maryam Ali Al‐Nesf, Fatima Ashkanani, Adeeb Bulkhi, Juan C. Cardet, Claudia Almendarez, Silvia Caimmi, Iván Cherrez, Enza D’Auria, Stephanie Dramburg, Motohiro Ebisawa, Naoko Fusayasu, Maximiliano Gomez, Sandra Gonzalez‐Diaz, Carla Irani, Andrey Kamaev, Connie Katelaris, Narinder Kaur, Oksana KurBacheva, José I. Larco, Désirée Larenas‐Linnemann, Margaret Li, Olga Patricia Monge‐Ortega, Pablo Moreno, Oliver Pfaar, Cesar F. Pozo‐Beltrán, Marta E. Rubio, Jorge Sanchez, Giovanni Sedo, Silvia Uriarte, Lin Yang, Hao Chen, Rongfei Zhu, Pascal Demoly, Moises A. Calderon, on behalf of the CHOICE‐Global Survey Team   +42 more
wiley   +1 more source

Positive-Strand RNA Viral RdRps: From Structure Conservation and Activity Assay to Drug Development

Molecules
Positive-strand RNA viruses represented by SARS-CoV-2 and DENV spread globally with high infectivity and frequent mutations, posing a severe threat to human health. However, specific and effective antiviral drugs remain limited.
Siyuan Zhao, Ziyu Lin, Minglian Wang
doaj   +1 more source

Molecular Evolutionary Analyses of the RNA-Dependent RNA Polymerase Region in Norovirus Genogroup II

Frontiers in Microbiology, 2018
Noroviruses are the leading cause of viral gastroenteritis in humans across the world. RNA-dependent RNA polymerase (RdRp) plays a critical role in the replication of the viral genome.
Keita Ozaki, Keita Ozaki, Yuki Matsushima, Koo Nagasawa, Takumi Motoya, Akihide Ryo, Makoto Kuroda, Kazuhiko Katayama, Hirokazu Kimura, Hirokazu Kimura   +9 more
doaj   +1 more source

In Situ Hybridization and RT‐PCR Detection of Nervous Necrosis Virus in Fourfinger Threadfin, Eleutheronema tetradactylum, in Taiwan

Journal of Fish Diseases, Volume 49, Issue 10, October 2026.
ABSTRACT Between April and July 2020, suspected outbreaks of nervous necrosis virus (NNV) infection were observed in fourfinger threadfin (Eleutheronema tetradactylum) fingerling hatcheries in Pingtung County, southern Taiwan. Affected fish exhibited spiral swimming behaviour and abdominal distension, resulting in mortality rates between 50% and 100 ...
Chia‐Yu Hsieh, Shang‐Ting Wu, Chun‐Ying Lin   +2 more
wiley   +1 more source