Results 51 to 60 of about 29,952 (187)

RdRp mutations are associated with SARS-CoV-2 genome evolution

PeerJ, 2020
Abstract COVID-19, caused by the novel SARS-CoV-2 virus, started in China in late 2019, and soon became a global pandemic. With the help of thousands of viral genome sequences that have been accumulating, it has become possible to track the evolution of viral genome over time as it spread across the world.
Doğa Eskier, Gökhan Karakülah, Aslı Suner, Yavuz Oktay   +3 more
openaire   +4 more sources

Development of a method for evaluating the mRNA transcription activity of influenza virus RNA-dependent RNA polymerase through real-time reverse transcription polymerase chain reaction

Virology Journal, 2021
Background The development of an influenza RNA-dependent RNA polymerase (RdRp) inhibitor is required; therefore, a method for evaluating the activity of influenza RdRp needs to be developed.
Yuka Horio, Mototada Shichiri, Yuji Isegawa   +2 more
doaj   +1 more source

Chicken Pulmonary MicroRNAs Targeting the PB2 (Segment 1) of Avian Influenza Virus

Animal Research and One Health, EarlyView.
The PB2 segment of H5N1 is essential for replication and host adaptation. We screened 200 miRNAs and identified five (gga‐miR‐17‐3p, gga‐miR‐29a‐5p, gga‐miR‐1718, gga‐miR‐16c‐5p, and gga‐miR‐1744‐5p) using thermodynamic stability of heteroduplex, seed sequence complementarity, conservation, and accessibility, offering insights into host antiviral ...
Akanksha Choudhary, Nidhishree N. S, Rakesh Kumar Pundir, Muhasin Asaf V. N, Anamika Mishra, Ashwin Ashok Raut, Megha Agarwal, Amod Kumar   +7 more
wiley   +1 more source

Evolutionary inferences from the analysis of mutation dynamics in the SARS-CoV-2 replication-transcription complex

Вавиловский журнал генетики и селекции
The SARS-CoV-2 virus continues to evolve and remains a significant public health threat, while the worldwide monitoring and sequencing of its genomic variants provide a unique opportunity to study its evolution and better understand its molecular ...
A. Yu. Palyanov, A. P. Devyaterikov, N. V. Palyanova, A. M. Shestopalov   +3 more
doaj   +1 more source

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source

Pharmacokinetic Assessment of Atazanavir and Favipiravir Following Echinacea Supplementation: A Controlled Herb–Drug Interaction Investigation

Biopharmaceutics &Drug Disposition, EarlyView.
Pharmacokinetic interactions between Echinacea and two antiviral drugs, favipiravir and atazanavir, were assessed in rats. The findings suggest that Echinacea does not significantly affect the pharmacokinetics of favipiravir and atazanavir. These results provide preliminary evidence that concurrent use of Echinacea with these antiviral drugs may be ...
Siva Nageswara Rao Gajula, Jeevan Sai Kallam, Aarika Kanukolanu, Ganesh Korada, Lakshmi Vineela Nalla   +4 more
wiley   +1 more source

RNA-dependent RNA polymerase (RdRp) natural antiviral inhibitors: a review

Medicinal Chemistry Research, 2022
Viral diseases are the cause of many global epidemics, leading to deaths, affecting the quality of life of populations, and impairing public health. The limitations in the treatment of viral diseases and the constant resistance to conventional antiviral treatments encourage researchers to discover new compounds.
Daniela Regina Buch Leite, Karen Mary Mantovani, Solange Pereira Cordeiro, Filipe Barros Maia, Fernando Cesar Martins Betim, Elisiane de Bona Sartor, Deise Prehs Montrucchio, Josiane de Fátima Gaspari Dias, Obdulio Gomes Miguel, Marilis Dallarmi Miguel   +9 more
openaire   +2 more sources

RNF138-Mediated Ubiquitination and Degradation of NS5 Restricts Tick-Borne Encephalitis Virus Infection. [PDF]

Adv Sci (Weinh)
Host‐specific compatibility between RNF138‐like proteins and flavivirus NS5 determines NS5 stability. Mammalian RNF138 but not arthropod homologs recognizes and induces conserved NS5/RdRp K48‐linked ubiquitination and proteasomal degradation, thereby restricting viral replication. Ectopic RNF138 in mice attenuates TBEV‐induced pathogenesis. (Created in
Sun J, Yang W, Zhou H, Li S, Jiang X, Gu J, Zhang W.   +6 more
europepmc   +2 more sources

Metal nanostructure‐coupled label‐free localized surface plasmon resonance biosensors for rapid and sensitive disease diagnosis

BMEMat, EarlyView.
LSPR biosensing enables rapid, sensitive, and low‐sample‐volume detection of biomarkers, with broad applications in diagnosing cancer, infectious, and chronic diseases. Advances in nanostructure design, micro/nanofabrication, and microfluidic integration have expanded the potential of LSPR sensors in biomedical diagnostics.
Zhaoxin Geng, Yunfei Sha, Jiongyan Yang, Hongru Yang, Xiao Liang   +4 more
wiley   +1 more source

RDRP: Reward-Driven Request Prioritization for e-Commerce web sites [PDF]

Electronic Commerce Research and Applications, 2010
Meeting client Quality-of-Service (QoS) expectations proves to be a difficult task for the providers of e-Commerce services, especially when web servers experience overload conditions, which cause increased response times and request rejections, leading to user frustration, lowered usage of the service and reduced revenues.
Alexander Totok, Vijay Karamcheti
openaire   +2 more sources