Results 51 to 60 of about 46,334 (221)

Molecular and phylogenetic characterization of honey bee viruses, Nosema microsporidia, protozoan parasites, and parasitic mites in China [PDF]

, 2008
China has the largest number of managed honey bee colonies, which produce the highest quantity of honey and royal jelly in the world; however, the presence of honey bee pathogens and parasites has never been rigorously identified in Chinese apiaries.
Yang, Bu, Peng, Guangda, Li, Tianbang, Kadowaki, Tatsuhiko   +3 more
core   +2 more sources

Cu(0)-RDRP of styrene: balancing initiator efficiency and dispersity [PDF]

Polymer Chemistry, 2018
The optimisation of all components within Cu(0)-wire mediated polymerisation of styrene is illustrated yielding well-defined polystyrene with enhanced initiator efficiency and dispersity at higher molecular weights.
Richard Whitfield, Athina Anastasaki, Glen R. Jones, David M. Haddleton   +3 more
openaire   +3 more sources

Virtual screening for NS5B inhibitors of Hepatitis C virus [PDF]

, 2012
Hepatitis C Virus (HCV) infection is a serious cause of chronic liver disease worldwide with more than 170 million infected individuals at a risk of developing significant morbidity and mortality.
Achuthsankar S. Nair, Amjesh R, Sugunan V.S.   +2 more
core   +2 more sources

RNA-dependent RNA polymerase (RdRp) natural antiviral inhibitors: a review

Medicinal Chemistry Research, 2022
Viral diseases are the cause of many global epidemics, leading to deaths, affecting the quality of life of populations, and impairing public health. The limitations in the treatment of viral diseases and the constant resistance to conventional antiviral treatments encourage researchers to discover new compounds.
Daniela Regina Buch Leite, Karen Mary Mantovani, Solange Pereira Cordeiro, Filipe Barros Maia, Fernando Cesar Martins Betim, Elisiane de Bona Sartor, Deise Prehs Montrucchio, Josiane de Fátima Gaspari Dias, Obdulio Gomes Miguel, Marilis Dallarmi Miguel   +9 more
openaire   +2 more sources

Photolyzable Polymer Brushes: Subtractive 3D Structuring of Surfaces Using Water and Light

Angewandte Chemie, EarlyView.
Facile structuring of polymer brushes is achieved by flipping the process from controlled growth to controlled brush photolysis. Using surface‐initiated radical ring‐opening polymerization of cyclic monomers with photocleavable cyclobutane rings, photodegradable targets are embedded into the polymer chains. The enabled continuous subtractive patterning
Henrik Kalmer, Federica Sbordone, Phuong T. Do, Kai Mundsinger, Hazal Kayas, Robert T. Jones, Jayanti Mendhi, Tim R. Dargaville, Damien G. Harkin, Lukas Michalek, Andrew Nelson, Hendrik Frisch   +11 more
wiley   +2 more sources

Targeting RdRp of SARS-CoV-2 with De Novo Molecule Generation

ACS Applied Bio Materials, 2023
Viruses are known for their extremely high mutation rates, allowing them to evade both the human immune system and many forms of standard medicine. Despite this, the RNA Dependent RNA Polymerase (RdRp) of the RNA viruses has been largely conserved, and any significant mutation to this protein is unlikely.
Amal Vijay, Venkata Sai Sreyas Adury, Arnab Mukherjee   +2 more
openaire   +2 more sources

Interaction of Sesbania mosaic virus (SeMV) RNA-dependent RNA polymerase (RdRp) with the p10 domain of polyprotein 2a and its implications in SeMV replication

FEBS Open Bio, 2014
Identification of viral encoded proteins that interact with RNA-dependent RNA polymerase (RdRp) is an important step towards unraveling the mechanism of replication.
Kunduri Govind, Arindam Bakshi, Handanahal S. Savithri   +2 more
doaj   +1 more source

Blocking Zika virus vertical transmission. [PDF]

, 2018
The outbreak of the Zika virus (ZIKV) has been associated with increased incidence of congenital malformations. Although recent efforts have focused on vaccine development, treatments for infected individuals are needed urgently. Sofosbuvir (SOF), an FDA-
Beltrão-Braga, Patricia CB, Corbett, Kevin D, Cugola, Fernanda R, Fernandes, Isabella R, Herai, Roberto H, Huang, Chun-Teng, Kolar, Matthew J, Macia, Angela, Mesci, Pinar, Momper, Jeremiah D, Montefusco, Sandro, Moore, Spencer M, Muotri, Alysson R, Pinto, Antonella, Rosenberg, Scott C, Russo, Fabiele B, Saghatelian, Alan, Sheets, Nicholas, Shiryaev, Sergey A, Shresta, Sujan, Siqueira-Neto, Jair L, Suarez, Nicole A, Tejwani, Leon, Terskikh, Alexey V   +23 more
core   +2 more sources

Ultra-low volume oxygen tolerant photoinduced Cu-RDRP [PDF]

Polymer Chemistry, 2019
We introduce the first oxygen tolerant ultra-low volume (as low as 5 μL) photoinduced Cu-RDRP of a range of hydrophobic, hydrophilic and semi-fluorinated monomers.
Evelina Liarou, Athina Anastasaki, Richard Whitfield, Carmelo E. Iacono, Georgios Patias, Nikolaos G. Engelis, Arkadios Marathianos, Glen R. Jones, David M. Haddleton   +8 more
openaire   +2 more sources

Rescue of a genotype 4 human hepatitis E virus from cloned cDNA and characterization of intergenotypic chimeric viruses in cultured human liver cells and in pigs [PDF]

, 2012
Hepatitis E virus (HEV) is an important but extremely understudied human pathogen. Genotypes 1 and 2 are restricted to humans, whereas genotypes 3 and 4 are zoonotic, infecting both humans and pigs.
Alicia R. Feagins, Barbara A. Dryman, Caitlin M. Cossaboom, Emerson, Feagins, Geissler, Laura Córdoba, Li, Meng, Meng, Moss, Strauss, Tanja Opriessnig, Xiang-Jin Meng, Yao-Wei Huang, Zafrullah   +15 more
core   +1 more source