Results 41 to 50 of about 36,268 (188)

Results of the RdRp BLASTx analysis.

, 2019
Results of the RdRp BLASTx analysis.
Kim A. Piera (7538009), Hafsa Rana (8201886), Timothy William (286967), Karrie Rose (129534), Miles P. Davenport (8201889), John-Sebastian Eden (251178), Edward C. Holmes (8067413), Matthew J. Grigg (7464944), Nicholas M. Anstey (7464926), Justine Charon (6335501)   +9 more
core   +1 more source

Near‐Infrared Light‐Induced Reversible Deactivation Radical Polymerization: Expanding Frontiers in Photopolymerization

Advanced Science, 2023
Photoinduced reversible deactivation radical polymerization (photo‐RDRP) or photoinduced controlled/living radical polymerization has emerged as a versatile and powerful technique for preparing functional and advanced polymer materials under mild ...
Zilong Wu, Cyrille Boyer
doaj   +1 more source

A Dual‐Membrane Biomimetic Nanoplatform Enables Triple‐Modal Therapy Against SARS‐CoV‐2 Through Viral Decoy, Inflammation Neutralizing, and Intracellular RNAi

Advanced Science, EarlyView.
[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...
Hui Li, Bohan Zhang, Chao Shang, Yi Li, Te Zhao, Shengya Liu, Dan Liu, Junwei Che, Cuiling Zhang, Pinghui Wu, Wenjie Yang, Junjie Ding, Yuhua Ran, Yanan Zhai, Haihua Xiao, Jing Gao, Xiao Li, Chunsheng Gao, Lin Li, Zhiping Li   +19 more
wiley   +1 more source

Identification of novel mutations in RNA-dependent RNA polymerases of SARS-CoV-2 and their implications on its protein structure [PDF]

PeerJ, 2020
The rapid development of the SARS-CoV-2 mediated COVID-19 pandemic has been the cause of significant health concern, highlighting the immediate need for effective antivirals. SARS-CoV-2 is an RNA virus that has an inherently high mutation rate.
Gyanendra Bahadur Chand, Atanu Banerjee, Gajendra Kumar Azad   +2 more
doaj   +2 more sources

NS1‐Induced PARP1 Phase Transitions Prolongs Host Transcriptional Pausing to Promote Influenza A Virus Replication

Advanced Science, EarlyView.
After IAV infection, NS1 induces PARP1 phase transition, reducing molecular mobility in condensates, prolonging host transcriptional pause, aiding RdRp cap snatching, and promoting viral transcription. ABSTRACT Influenza A virus (IAV) commandeers host transcriptional machinery to replicate, but mechanisms remain elusive.
Shufeng Ma, Changyuan Kang, Xixian Liu, Lichao Yang, Mengyi Li, Yuting Ye, Jianfang Zhang, Yingjun Li, Guanghui Jin, Yang Liu, Xiaohong Chen, Kexin Wang, Zifeng Yang   +12 more
wiley   +1 more source

Recombination of NoV RdRp/capsid genes.

, 2014
Recombination of NoV RdRp/capsid genes.
Van Thai Than (562959), Thoi Cong Truong (674013), Wonyong Kim (331039)   +2 more
core   +1 more source

Corilagin inhibits SARS-CoV-2 replication by targeting viral RNA-dependent RNA polymerase

Acta Pharmaceutica Sinica B, 2021
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has become one major threat to human population health. The RNA-dependent RNA polymerase (RdRp) presents an ideal target of antivirals, whereas nucleoside analogs inhibitor is hindered by the ...
Quanjie Li, Dongrong Yi, Xiaobo Lei, Jianyuan Zhao, Yongxin Zhang, Xiangling Cui, Xia Xiao, Tao Jiao, Xiaojing Dong, Xuesen Zhao, Hui Zeng, Chen Liang, Lili Ren, Fei Guo, Xiaoyu Li, Jianwei Wang, Shan Cen   +16 more
doaj   +1 more source

Controlled Atom Transfer Radical Depolymerization

Advanced Science, EarlyView.
Controlled atom transfer radical depolymerization allows for precise, uniform shortening of polymer chains to yield monomers on demand. By tuning catalyst concentration and temperature, this strategy prioritizes deactivation to maintain molecular weight control throughout depolymerization.
Dimitra Mantzara, Richard Whitfield, Glen R. Jones, Nghia P. Truong, Athina Anastasaki   +4 more
wiley   +1 more source

PBV RdRP data collection and refinement statistics.

, 2016
PBV RdRP data collection and refinement statistics.
Outi L. Lyytinen (3174675), Yukimatsu Toh (3174678), Yusong R. Guo (3174681), Yizhi J. Tao (3174687), Minna M. Poranen (115053), Aaron M. Collier (3174684)   +5 more
core   +1 more source

Prepolymerization Enables On‐Demand Viscosity Tuning for Xolography of Soft Hydrogels

Advanced Science, EarlyView.
A facile in situ prepolymerization strategy enables on‐demand viscosity tuning across three orders of magnitude without external thickeners, transforming low‐viscosity resins into printable formulations for Xolography. The approach suppresses sedimentation, lowers curing dose, enables high‐fidelity support‐free fabrication, and produces advanced ...
Xichuan Li, Marcus Reuter, Linguangze Zhuo, Xueheng Dai, Camille Tribout, Nathaniel Corrigan, Jin Zhang, Cyrille Boyer   +7 more
wiley   +1 more source