Results 41 to 50 of about 29,350 (193)

Ferritinophagy Rewires Carnitine‐Dependent Lipid Metabolism to Inhibit PRRSV and IAV Replication

Advanced Science, EarlyView.
NCOA4‐mediated ferritinophagy reprograms carnitine metabolism by disrupting Fe‐S cluster biogenesis, thereby establishing an iron‐lipid axis that suppresses various viruses, including PRRSV and IAV. However, viruses counteract this mechanism by degrading NCOA4.
Kaifeng Guan, Chenyang Yuan, Zekun Meng, Yanan Wang, Xueying Zhai, Chunjie Huang, Xiang Zhou, Gaiping Zhang   +7 more
wiley   +1 more source

Evaluation of potential anti-RNA-dependent RNA polymerase (RdRP) drugs against the newly emerged model of COVID-19 RdRP using computational methods

Biophysical Chemistry, 2021
Despite all the efforts to treat COVID-19, no particular cure has been found for this virus. Since developing antiviral drugs is a time-consuming process, the most effective approach is to evaluate the approved and under investigation drugs using in silico methods. Among the different targets within the virus structure, as a vital component in the life
Poustforoosh, Alireza, Hashemipour, Hassan, Tuzun, Burak, Pardakhty, Abbas, Mehrabani, Mehrnaz, Nematollahi, Mohammad Hadi   +5 more
openaire   +2 more sources

Evolutionary inferences from the analysis of mutation dynamics in the SARS-CoV-2 replication-transcription complex

Вавиловский журнал генетики и селекции
The SARS-CoV-2 virus continues to evolve and remains a significant public health threat, while the worldwide monitoring and sequencing of its genomic variants provide a unique opportunity to study its evolution and better understand its molecular ...
A. Yu. Palyanov, A. P. Devyaterikov, N. V. Palyanova, A. M. Shestopalov   +3 more
doaj   +1 more source

A Structure-Function Diversity Survey of the RNA-Dependent RNA Polymerases From the Positive-Strand RNA Viruses

Frontiers in Microbiology, 2019
The RNA-dependent RNA polymerases (RdRPs) encoded by the RNA viruses are a unique class of nucleic acid polymerases. Each viral RdRP contains a 500–600 residue catalytic module with palm, fingers, and thumb domains forming an encircled human right hand ...
Hengxia Jia, Hengxia Jia, Peng Gong
doaj   +1 more source

Corilagin inhibits SARS-CoV-2 replication by targeting viral RNA-dependent RNA polymerase

Acta Pharmaceutica Sinica B, 2021
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has become one major threat to human population health. The RNA-dependent RNA polymerase (RdRp) presents an ideal target of antivirals, whereas nucleoside analogs inhibitor is hindered by the ...
Quanjie Li, Dongrong Yi, Xiaobo Lei, Jianyuan Zhao, Yongxin Zhang, Xiangling Cui, Xia Xiao, Tao Jiao, Xiaojing Dong, Xuesen Zhao, Hui Zeng, Chen Liang, Lili Ren, Fei Guo, Xiaoyu Li, Jianwei Wang, Shan Cen   +16 more
doaj   +1 more source

RNF138‐Mediated Ubiquitination and Degradation of NS5 Restricts Tick‐Borne Encephalitis Virus Infection

Advanced Science, EarlyView.
Host‐specific compatibility between RNF138‐like proteins and flavivirus NS5 determines NS5 stability. Mammalian RNF138 but not arthropod homologs recognizes and induces conserved NS5/RdRp K48‐linked ubiquitination and proteasomal degradation, thereby restricting viral replication. Ectopic RNF138 in mice attenuates TBEV‐induced pathogenesis. (Created in
Jialiang Sun, Weijing Yang, Hao Zhou, Shuai Li, Xin Jiang, Jianyang Gu, Wenyan Zhang   +6 more
wiley   +1 more source

Mutations in RNA‐dependent RNA polymerase could be major cause of high pandemic potential of SARS‐CoV‐2: An in‐silico study

Indonesian Journal of Biotechnology
Human coronaviruses (HCoVs) are responsible for mild common cold to severe pneumonia‐like symptoms in infected individuals. The first HCoV was HCoV‐229E, discovered in 1962 in the US, which causes moderate symptoms.
Bhawna Sharma, Bennet Angel, Annette Angel, Vinod Joshi, Shareef Mohammed Buvvaji, Neha Singh, Khushbu Kumari, Aarya Chitransh, Poorna Khaneja, Devendra Kumar   +9 more
doaj   +1 more source

Identification of novel mutations in RNA-dependent RNA polymerases of SARS-CoV-2 and their implications on its protein structure [PDF]

PeerJ, 2020
The rapid development of the SARS-CoV-2 mediated COVID-19 pandemic has been the cause of significant health concern, highlighting the immediate need for effective antivirals. SARS-CoV-2 is an RNA virus that has an inherently high mutation rate.
Gyanendra Bahadur Chand, Atanu Banerjee, Gajendra Kumar Azad   +2 more
doaj   +2 more sources

RdRp mutations are associated with SARS-CoV-2 genome evolution

PeerJ, 2020
Abstract COVID-19, caused by the novel SARS-CoV-2 virus, started in China in late 2019, and soon became a global pandemic. With the help of thousands of viral genome sequences that have been accumulating, it has become possible to track the evolution of viral genome over time as it spread across the world.
Doğa Eskier, Gökhan Karakülah, Aslı Suner, Yavuz Oktay   +3 more
openaire   +4 more sources

Evaluation of the Antiviral Characteristics of Tetragonula sapiens Propolis from Indonesia Using In Vitro and In Silico Methods

International Journal of Technology
The previous outbreaks of syndrome coronavirus 2 (SARS-CoV-2) are indications of the need for effective antiviral agents to mitigate disease severity and future outbreaks. In this context, natural products such as propolis have gained attention for their
Safira Candra Asih, Mohammad Nasikin, Jim-Tong Horng, Hui-Ping Tsai, Shan-Ko Tsai, Cheng-Hsun Chiu, Diah Kartika Pratami, Abdul Mun’im, Muhamad Sahlan   +8 more
doaj   +1 more source