Results 21 to 30 of about 36,268 (188)

The tunnels of RdRp and major difference of RdRp between MCRV and tMCRV.

, 2023
(A) indicates the four tunnels of RdRp. The asterisks indicate the positions of tunnels. The color schemes of RdRp and capsid are same as that in Figs 1 and 5.
Qinfen Zhang (379232), Jason T. Kaelber (15339015), Wen Jiang (274586), Shanshan Liu (315561), Xudong Jia (521566), Shaoping Weng (117668), Haidong Xu (35210), Matthew L. Baker (14930447), Yuanzhu Gao (3564110), Jianguo He (117672)   +9 more
core   +1 more source

Virtual screening of natural products as potential inhibitors of SARS-CoV-2 main protease, RNA-dependent RNA polymerase (RdRp) and Spike Protein: Database design, molecular docking and molecular dynamic study [PDF]

Avicenna Journal of Phytomedicine
Objective: COVID-19 is caused by the SARS-CoV-2 virus. In this study, around 300 herbal compounds were screened virtually to find the best anti-COVID-19 structures. Materials and Methods: An extensive search in electronic databases was done.
Motahareh Boozari, Zeinab Amiri Tehranizadeh, Hossein Hosseinzadeh   +2 more
doaj   +1 more source

Nucleotide sequences of contigs with RdRp genes

, 2021
Nucleotide sequences of contigs, which were assembled from FLDS data and identified as possible viruses with RdRp ...
Junya Hirai (11657518)
core   +1 more source

RNA-Dependent RNA Polymerase from Heterobasidion RNA Virus 6 Is an Active Replicase In Vitro

Viruses, 2021
Heterobasidion RNA virus 6 (HetRV6) is a double-stranded (ds)RNA mycovirus and a member of the recently established genus Orthocurvulavirus within the family Orthocurvulaviridae.
Alesia A. Levanova, Eeva J. Vainio, Jarkko Hantula, Minna M. Poranen   +3 more
doaj   +1 more source

Importance of Zika Virus NS5 Protein for Viral Replication

Pathogens, 2019
Zika virus is the latest addition to an ever-growing list of arboviruses that are causing outbreaks with serious consequences. A few mild cases were recorded between 1960 and 1980 until the first major outbreak in 2007 on Yap Island. This was followed by
Hesham Elshahawi, Sharifah Syed Hassan, Vinod Balasubramaniam   +2 more
doaj   +1 more source

Study of Eclipta prostrata compounds with potential inhibition of RNA-dependent RNA polymerase (RdRp) enzyme of Sars-CoV-2 virus using molecular docking

Tạp chí Khoa học Đại học Mở Thành phố Hồ Chí Minh - Kỹ thuật và Công nghệ, 2023
The Covid-19 pandemic has emerged as a global health crisis, with no definitive end in sight. In this study, molecular docking was employed to screen compounds derived from Eclipta prostrata for their potential inhibitory effects on the RNA-dependent RNA
Hồ Thiên Hoàng, Nguyễn Thị Uyên Thanh, Quan Quốc Đăng, Bùi Đình Thạch   +3 more
doaj   +1 more source

Identification of Polyphenol Derivatives as Novel SARS-CoV-2 and DENV Non-Nucleoside RdRp Inhibitors [PDF]

, 2022
The Coronavirus Disease 2019 (COVID-19) and dengue fever (DF) pandemics both remain to be significant public health concerns in the foreseeable future. Anti-SARS-CoV-2 drugs and vaccines are both indispensable to eliminate the epidemic situation.
Herdewijn, Piet, Hongtao Xu, Laura Vangeel, Kang, Dongwei, Piet Herdewijn, Lanlan Jing, Schols, Dominique, Xu, Hongtao, Fikatas, Antonios, Jochmans, Dirk, Neyts, Johan, Peng Zhan, Oeyen, Merel, Zhan, Peng, Letian Song, Antonios Fikatas, Johan Neyts, Zhao, Fabao, Yusen Cheng, Gao, Shenghua, De Jonghe, Steven, Dirk Jochmans, Fabao Zhao, Song, Letian, Shenghua Gao, Vangeel, Laura, Steven De Jonghe, Xinyong Liu, Merel Oeyen, Jing, Lanlan, Cheng, Yusen, Dominique Schols, Liu, Xinyong, Dongwei Kang   +33 more
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The problem of SARS-CoV-2 virus resistance to direct-acting antivirals

Биопрепараты: Профилактика, диагностика, лечение
INTRODUCTION. The high prevalence of mutations in the SARS-CoV-2 genome raises particular concerns about the resistance of the virus to current antiviral therapy, including inhibitors of the main protease, or 3C-like protease (3CLpro), and RNA-dependent ...
E. L. Gasich, E. N. Krotkova, A. D. Kasko, K. Yu. Bulda, A. G. Krasko, E. A. Dorofeeva, I. A. Karpov   +6 more
doaj   +1 more source

Effect of Genomic and Amino Acid Sequence Mutation on Virulence and Therapeutic Target of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS COV-2)

Infection and Drug Resistance, 2021
Endriyas Kelta Wabalo, Abebe Dukessa Dubiwak, Mengistu Welde Senbetu, Tariku Sime Gizaw Department of Biomedical Sciences, Faculty of Medical Sciences, Institute of Health, Jimma University, Jimma, EthiopiaCorrespondence: Endriyas Kelta WabaloDepartment ...
Kelta Wabalo E, Dukessa Dubiwak A, Welde Senbetu M, Sime Gizaw T   +3 more
doaj  

ORF4 promotes viral RdRp activity.

, 2016
(A) Left panel: SDS-PAGE and Silver staining of Flag antibody immunoprecipitated samples from Huh7 cells transiently transfected with pUNO empty vector or pUNO RdRp-flag vector. Right panel: Western of left panel samples using anti-Flag antibody.
Shalimar (538335), Vidya P. Nair (2585419), Karishma Bakshi (2585437), Milan Surjit (2585434), Abhilasha Madhvi (2585416), Akriti Srivastava (2585431), Baibaswata Nayak (292413), Saumya Anang (2585428), Chandru Subramani (2585425), Ranjith Kumar CT (2585422)   +9 more
core   +1 more source