Results 21 to 30 of about 29,350 (193)

Virtual screening of natural products as potential inhibitors of SARS-CoV-2 main protease, RNA-dependent RNA polymerase (RdRp) and Spike Protein: Database design, molecular docking and molecular dynamic study [PDF]

Avicenna Journal of Phytomedicine
Objective: COVID-19 is caused by the SARS-CoV-2 virus. In this study, around 300 herbal compounds were screened virtually to find the best anti-COVID-19 structures. Materials and Methods: An extensive search in electronic databases was done.
Motahareh Boozari, Zeinab Amiri Tehranizadeh, Hossein Hosseinzadeh   +2 more
doaj   +1 more source

Initiation of RNA Polymerization and Polymerase Encapsidation by a Small dsRNA Virus. [PDF]

PLoS Pathogens, 2016
During the replication cycle of double-stranded (ds) RNA viruses, the viral RNA-dependent RNA polymerase (RdRP) replicates and transcribes the viral genome from within the viral capsid.
Aaron M Collier, Outi L Lyytinen, Yusong R Guo, Yukimatsu Toh, Minna M Poranen, Yizhi J Tao   +5 more
doaj   +1 more source

Molecular Evolutionary Analyses of the RNA-Dependent RNA Polymerase (RdRp) Region and VP1 Gene in Human Norovirus Genotypes GII.P6-GII.6 and GII.P7-GII.6

Viruses, 2023
To understand the evolution of GII.P6-GII.6 and GII.P7-GII.6 strains, the prevalent human norovirus genotypes, we analysed both the RdRp region and VP1 gene in globally collected strains using authentic bioinformatics technologies.
Tomoko Takahashi, Ryusuke Kimura, Tatsuya Shirai, Mitsuru Sada, Toshiyuki Sugai, Kosuke Murakami, Kazuhiko Harada, Kazuto Ito, Yuki Matsushima, Fuminori Mizukoshi, Kaori Okayama, Yuriko Hayashi, Mayumi Kondo, Tsutomu Kageyama, Yoshiyuki Suzuki, Haruyuki Ishii, Akihide Ryo, Kazuhiko Katayama, Kiyotaka Fujita, Hirokazu Kimura   +19 more
doaj   +1 more source

Importance of Zika Virus NS5 Protein for Viral Replication

Pathogens, 2019
Zika virus is the latest addition to an ever-growing list of arboviruses that are causing outbreaks with serious consequences. A few mild cases were recorded between 1960 and 1980 until the first major outbreak in 2007 on Yap Island. This was followed by
Hesham Elshahawi, Sharifah Syed Hassan, Vinod Balasubramaniam   +2 more
doaj   +1 more source

The Functional Implications of Broad Spectrum Bioactive Compounds Targeting RNA-Dependent RNA Polymerase (RdRp) in the Context of the COVID-19 Pandemic

Viruses, 2023
Background: As long as COVID-19 endures, viral surface proteins will keep changing and new viral strains will emerge, rendering prior vaccines and treatments decreasingly effective.
Brittany A. Comunale, Robin J. Larson, Erin Jackson-Ward, Aditi Singh, Frances L. Koback, Lilly D. Engineer   +5 more
doaj   +1 more source

In silico investigation to identify potential small molecule inhibitors of the RNA-dependent RNA polymerase (RdRp) nidovirus RdRp-associated nucleotidyltransferase domain

Chemical Physics Letters, 2021
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA-dependent RNA polymerase (RdRp) is a promising target for antiviral drugs. In this study, a chemical library (n = 300) was screened against the nidovirus RdRp-associated nucleotidyltransferase (NiRAN) domain.
Eleni Pitsillou, Julia Liang, Helen Yu Meng Huang, Andrew Hung, Tom C. Karagiannis   +4 more
openaire   +2 more sources

The potential of Paritaprevir and Emetine as inhibitors of SARS-CoV-2 RdRp

Saudi Journal of Biological Sciences, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA-dependent RNA polymerase (RdRp) is a well-characterized therapeutic target which is a key player driving the viral replication and transcription machinery. The recent elucidation of the experimental structure of SARS-CoV-2 RdRp enzyme complexed with triphosphate form of Remdesivir (RTP ...
Gurung, Arun Bahadur, Ali, Mohammad Ajmal, Lee, Joongku, Farah, Mohammad Abul, Al-Anazi, Khalid Mashay   +4 more
openaire   +2 more sources

RNA-Dependent RNA Polymerase from Heterobasidion RNA Virus 6 Is an Active Replicase In Vitro

Viruses, 2021
Heterobasidion RNA virus 6 (HetRV6) is a double-stranded (ds)RNA mycovirus and a member of the recently established genus Orthocurvulavirus within the family Orthocurvulaviridae.
Alesia A. Levanova, Eeva J. Vainio, Jarkko Hantula, Minna M. Poranen   +3 more
doaj   +1 more source

Effect of Genomic and Amino Acid Sequence Mutation on Virulence and Therapeutic Target of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS COV-2)

Infection and Drug Resistance, 2021
Endriyas Kelta Wabalo, Abebe Dukessa Dubiwak, Mengistu Welde Senbetu, Tariku Sime Gizaw Department of Biomedical Sciences, Faculty of Medical Sciences, Institute of Health, Jimma University, Jimma, EthiopiaCorrespondence: Endriyas Kelta WabaloDepartment ...
Kelta Wabalo E, Dukessa Dubiwak A, Welde Senbetu M, Sime Gizaw T   +3 more
doaj  

Study of Eclipta prostrata compounds with potential inhibition of RNA-dependent RNA polymerase (RdRp) enzyme of Sars-CoV-2 virus using molecular docking

Tạp chí Khoa học Đại học Mở Thành phố Hồ Chí Minh - Kỹ thuật và Công nghệ, 2023
The Covid-19 pandemic has emerged as a global health crisis, with no definitive end in sight. In this study, molecular docking was employed to screen compounds derived from Eclipta prostrata for their potential inhibitory effects on the RNA-dependent RNA
Hồ Thiên Hoàng, Nguyễn Thị Uyên Thanh, Quan Quốc Đăng, Bùi Đình Thạch   +3 more
doaj   +1 more source