Results 11 to 20 of about 29,350 (193)
Antiviral Protection via RdRP-Mediated Stable Activation of Innate Immunity. [PDF]
PLoS Pathogens, 2015 For many emerging and re-emerging infectious diseases, definitive solutions via sterilizing adaptive immunity may require years or decades to develop, if they are even possible.
Meghan M Painter +11 more
doaj +4 more sources
RdRp or RT, That is the Question [PDF]
Molecular Biology and Evolution, 2021 Abstract The RNA-dependent RNA polymerase (RdRp) of all known double-stranded RNA viruses is located within the viral particle and is responsible for the transcription and replication of the viral genome. Through an RT-PCR assay, we determined that purified virions, in vitro translated RdRp proteins, and purified recombinant RdRp ...
Mahtab Peyambari +2 more
openaire +2 more sources
Snapshots of a Non-Canonical RdRP in Action [PDF]
Viruses, 2021 RNA viruses typically encode their own RNA-dependent RNA polymerase (RdRP) to ensure genome replication and transcription. The closed “right hand” architecture of RdRPs encircles seven conserved structural motifs (A to G) that regulate the polymerization activity.
Diego S. Ferrero +2 more
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Conformational Changes in Motif D of RdRPs as Fidelity Determinant [PDF]
Structure, 2012 RNA-dependent RNA polymerases (RdRPs) are the central players in both transcription and viral genome replication. Using NMR spectroscopy, Yang and colleagues (in this issue of Structure) show that the conformational changes in the structural motif D of poliovirus RdRP correlate with the nature of the bound nucleotide (correct versus incorrect), with a ...
Verdaguer, Nuria, Ferrer-Orta, Cristina
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Inhibition of HEV Replication by FDA-Approved RdRp Inhibitors
ACS Omega, 2023 Hepatitis E virus (HEV) is primarily a hepatotropic virus that is responsible for acute hepatitis E in the general population and for chronic hepatitis in immunocompromised individuals. In the absence of a globally accessible vaccine, pegylated interferon-α and ribavirin are the only antiviral agents available for the treatment of chronic patients.
Preeti Hooda +4 more
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Experimental Gerontology, 2021 RT-qPCR is the most reliable molecular method for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we analyzed results of RT-qPCR obtained for 3044 patients diagnosed as SARS-CoV-2-positive using four different molecular tests utilizing five RNA sequences.
Mikuła-Pietrasik, Justyna +1 more
openaire +2 more sources
PLoS ONE, 2021 A newly identified coronavirus, designated as severe acute respiratory syndrome coronavirus 2 (SARS CoV-2), has spread rapidly from its epicenter in China to more than 150 countries across six continents.
Woong Sik Jang +10 more
doaj +1 more source
Cu(0)-RDRP of methacrylates in DMSO: importance of the initiator [PDF]
Polymer Chemistry, 2018 The controlled radical polymerization of methacrylates via Cu(0)-mediated RDRP is challenging in comparison to acrylates with most reports illustrating higher dispersities, lower monomer conversions and poorer end group fidelity relative to the acrylic analogues.
Glen R. Jones +6 more
openaire +4 more sources
Journal of Pure and Applied Microbiology, 2020 COVID-19 caused by SARS-CoV-2 has not only issued a pandemic situation but also lead to economic disaster and unprecedented health emergency. Being a close relative of Bat corona-virus, SARS and MERS it’s structural and sequence similarity has abled ...
Hiran Kanti Santra, Debdulal Banerjee
doaj +1 more source
Frontiers in Immunology, 2022 SARS-CoV-2 (severe acute respiratory syndrome coronavirus‐2), a member of the coronavirus family, appeared in 2019 and has caused the largest global public health and economic emergency in recent history, affecting almost all sectors of society. SARS-CoV-
Xiaoming Bai +11 more
doaj +1 more source