Results 11 to 20 of about 36,268 (188)

Antiviral Protection via RdRP-Mediated Stable Activation of Innate Immunity. [PDF]

PLoS Pathogens, 2015
For many emerging and re-emerging infectious diseases, definitive solutions via sterilizing adaptive immunity may require years or decades to develop, if they are even possible.
Meghan M Painter, James H Morrison, Laurie J Zoecklein, Tommy A Rinkoski, Jens O Watzlawik, Louisa M Papke, Arthur E Warrington, Allan J Bieber, William E Matchett, Kari L Turkowski, Eric M Poeschla, Moses Rodriguez   +11 more
doaj   +2 more sources

Structure of VP1 (RdRp).

, 2023
(A) The model of the RNA dependent RNA polymerase (RdRp), VP1, is shown. Like other Reovirus polymerases, VP1 contains an N-domain (yellow), C-domain (purple) and polymerase domain. The polymerase domain is further divided into the finger subdomain (blue)
Qinfen Zhang (379232), Jason T. Kaelber (15339015), Wen Jiang (274586), Shanshan Liu (315561), Xudong Jia (521566), Shaoping Weng (117668), Haidong Xu (35210), Matthew L. Baker (14930447), Yuanzhu Gao (3564110), Jianguo He (117672)   +9 more
core   +1 more source

Molecular Evolution of RNA-Dependent RNA Polymerase Region in Norovirus Genogroup I

Viruses, 2023
Norovirus is the leading viral agent of gastroenteritis in humans. RNA-dependent RNA polymerase (RdRp) is essential in the replication of norovirus RNA. Here, we present a comprehensive evolutionary analysis of the norovirus GI RdRp gene.
Nan Zhou, Yue Huang, Lu Zhou, Mingma Li, Hui Jin   +4 more
doaj   +1 more source

Development of a multiplex Loop-Mediated Isothermal Amplification (LAMP) assay for on-site diagnosis of SARS CoV-2.

PLoS ONE, 2021
A newly identified coronavirus, designated as severe acute respiratory syndrome coronavirus 2 (SARS CoV-2), has spread rapidly from its epicenter in China to more than 150 countries across six continents.
Woong Sik Jang, Da Hye Lim, Jung Yoon, Ahran Kim, Minsup Lim, Jeonghun Nam, Richard Yanagihara, Sook-Won Ryu, Bo Kyeung Jung, Nam-Hee Ryoo, Chae Seung Lim   +10 more
doaj   +1 more source

Identifying Small-Molecule Inhibitors of SARS-CoV-2 RNA-Dependent RNA Polymerase by Establishing a Fluorometric Assay

Frontiers in Immunology, 2022
SARS-CoV-2 (severe acute respiratory syndrome coronavirus‐2), a member of the coronavirus family, appeared in 2019 and has caused the largest global public health and economic emergency in recent history, affecting almost all sectors of society. SARS-CoV-
Xiaoming Bai, Xiaoming Bai, Hongmin Sun, Hongmin Sun, Shuo Wu, Shuo Wu, Yuhuan Li, Yuhuan Li, Lifei Wang, Lifei Wang, Bin Hong, Bin Hong   +11 more
doaj   +1 more source

Molecular Evolutionary Analyses of the RNA-Dependent RNA Polymerase (RdRp) Region and VP1 Gene in Human Norovirus Genotypes GII.P6-GII.6 and GII.P7-GII.6

Viruses, 2023
To understand the evolution of GII.P6-GII.6 and GII.P7-GII.6 strains, the prevalent human norovirus genotypes, we analysed both the RdRp region and VP1 gene in globally collected strains using authentic bioinformatics technologies.
Tomoko Takahashi, Ryusuke Kimura, Tatsuya Shirai, Mitsuru Sada, Toshiyuki Sugai, Kosuke Murakami, Kazuhiko Harada, Kazuto Ito, Yuki Matsushima, Fuminori Mizukoshi, Kaori Okayama, Yuriko Hayashi, Mayumi Kondo, Tsutomu Kageyama, Yoshiyuki Suzuki, Haruyuki Ishii, Akihide Ryo, Kazuhiko Katayama, Kiyotaka Fujita, Hirokazu Kimura   +19 more
doaj   +1 more source

Purification of SARS-CoV2-RdRp.

, 2021
A) Size exclusion chromatogram of recombinant SARS-CoV-2 RdRp (The peak indicated with a blue arrow represents the purified protein sample). (B) SDS-PAGE profile of the purified SARS-CoV-2 RdRp (The band indicated with a blue arrow represents the ...
Mohammed Ahmad (9120880), Bichitra Kumar Biswal (11426826), Tanmay Majumdar (250305), Richard Mariadasse (8180901), Satish Tiwari (9120886), Deepsikha Kar (9120889), Jeyaraman Jeyakanthan (253364), Sayan Chakraborty (234378), Abhisek Dwivedy (9120883), Shailendra Mani (415181), Prafullakumar Tailor (704915), Sankar Bhattacharyya (369988), Sudipta Sonar (10861950)   +12 more
core   +1 more source

Initiation of RNA Polymerization and Polymerase Encapsidation by a Small dsRNA Virus. [PDF]

PLoS Pathogens, 2016
During the replication cycle of double-stranded (ds) RNA viruses, the viral RNA-dependent RNA polymerase (RdRP) replicates and transcribes the viral genome from within the viral capsid.
Aaron M Collier, Outi L Lyytinen, Yusong R Guo, Yukimatsu Toh, Minna M Poranen, Yizhi J Tao   +5 more
doaj   +1 more source

Systematic structure guided clustering of chemical lead compounds targeting RdRp of SARS-CoV-2

, 2022
BACKGROUND: To combat the global health issue caused by SARS-CoV2, scientists are attempting various therapeutic approaches towards drug discovery including computational biology and drug-repurposing.
Alkhanani, Mustfa F., Janahi, Essam M., Haque, Shafiul, Bhardwaj, Tulika, Alsulimani, Ahmad, Wahid, Mohd, Tewari, Brij N., Almalki, Atiah H., Somvanshi, Pallavi   +8 more
core   +1 more source

The Functional Implications of Broad Spectrum Bioactive Compounds Targeting RNA-Dependent RNA Polymerase (RdRp) in the Context of the COVID-19 Pandemic

Viruses, 2023
Background: As long as COVID-19 endures, viral surface proteins will keep changing and new viral strains will emerge, rendering prior vaccines and treatments decreasingly effective.
Brittany A. Comunale, Robin J. Larson, Erin Jackson-Ward, Aditi Singh, Frances L. Koback, Lilly D. Engineer   +5 more
doaj   +1 more source