SARS-CoV-2 RdRp Inhibitors Selected from a Cell-Based SARS-CoV-2 RdRp Activity Assay System
Biomedicines, 2021 The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), urgently needs effective prophylactic and therapeutic drugs. RNA-dependent RNA polymerase (RdRp), essential for replicating and transcribing a viral RNA genome,
Sunoh Kwon, Young-Hee Jin
exaly +5 more sources
Antiviral Protection via RdRP-Mediated Stable Activation of Innate Immunity. [PDF]
PLoS Pathogens, 2015 For many emerging and re-emerging infectious diseases, definitive solutions via sterilizing adaptive immunity may require years or decades to develop, if they are even possible.
Meghan M Painter +11 more
doaj +4 more sources
In silico screening for human norovirus antivirals reveals a novel non-nucleoside inhibitor of the viral polymerase [PDF]
Scientific Reports, 2018 Human norovirus causes approximately 219,000 deaths annually, yet there are currently no antivirals available. A virtual screening of commercially available drug-like compounds (~300,000) was performed on the suramin and PPNDS binding-sites of the ...
Salvatore Ferla +8 more
doaj +3 more sources
RdRp or RT, That is the Question [PDF]
Molecular Biology and Evolution, 2021 Abstract The RNA-dependent RNA polymerase (RdRp) of all known double-stranded RNA viruses is located within the viral particle and is responsible for the transcription and replication of the viral genome. Through an RT-PCR assay, we determined that purified virions, in vitro translated RdRp proteins, and purified recombinant RdRp ...
Mahtab Peyambari +2 more
openaire +2 more sources
Snapshots of a Non-Canonical RdRP in Action [PDF]
Viruses, 2021 RNA viruses typically encode their own RNA-dependent RNA polymerase (RdRP) to ensure genome replication and transcription. The closed “right hand” architecture of RdRPs encircles seven conserved structural motifs (A to G) that regulate the polymerization activity.
Diego S. Ferrero +2 more
openaire +5 more sources
The worldwide search for the new mutations in the RNA-directed RNA Polymerase domain of SARS-CoV-2
Macedonian Veterinary Review, 2021 Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is an RNA virus, responsible for the current pandemic outbreak. In total, 200 genomes of the SARS‐CoV‐2 strains from four host organisms have been analyzed.
Siarhei A. Dabravolski +1 more
doaj +1 more source
Exploring RdRp–remdesivir interactions to screen RdRp inhibitors for the management of novel coronavirus 2019-nCoV [PDF]
SAR and QSAR in Environmental Research, 2020 A novel coronavirus recently identified in Wuhan, China (2019-nCoV) has resulted in an increasing number of patients globally, and has become a highly lethal pathogenic member of the coronavirus family affecting humans. 2019-nCoV has established itself as one of the most threatening pandemics that human beings have faced, and therefore analysis and ...
Singh, P.K., Pathania, S., Rawal, R.K.
openaire +2 more sources
Медицинская иммунология, 2022 Rapid emergence and evolution of novel SARS-CoV-2 variants has raised concerns about their potential impact on efficiency of currently available vaccines.
Ali A. Dawood
doaj +1 more source
Molecular Detection of Alpha- and Betacoronaviruses in Bats from Afar Region, Ethiopia. [PDF]
Vet Med SciBats are critical reservoirs of coronaviruses, yet gaps remain in understanding coronavirus diversity within bat populations in Eastern Ethiopia. A total of 141 bats were captured: 129 Chaerephon pumilus, 11 Epomophorus labiatus and 1 Mops condylurus. Coronaviruses detected in eight bats.
Mengesha B, Romha G, Gebrezgabiher G.
europepmc +2 more sources
Analysis the Effectiveness of Remdesivir, Galidesivir, Sofosbuvir, Tenofovir and Ribavirin as Potential Therapeutic Drug target against SARS-Cov-2 RNA-Dependent RNA Polymerase (RdRp): An in Silico Docking Study [PDF]
Journal of Research in Applied and Basic Medical Sciences, 2023 Background & Aims: The active site of RdRp-CoV is highly conserved, with two successive and surface-accessible aspartates in a beta-turn structure. Antiviral drugs Remdesivir, Galidesivir, Tenofovir, Sofosbuvir, and Ribavirin are known as inhibitors of ...
Rajneesh Prajapat, Suman Jain
doaj