Results 31 to 40 of about 29,350 (193)

RNA dependent RNA polymerase (RdRp) as a drug target for SARS-CoV2 [PDF]

Journal of Biomolecular Structure and Dynamics, 2021
RNA-dependent RNA polymerase (RdRp), also called nsp12, is considered a promising but challenging drug target for inhibiting replication and hence, the growth of various RNA-viruses. In this report, a computational study is performed to offer insights on the binding of Remdesivir and Galidesivir with SARS-CoV2 RdRp with natural substrate, ATP, as the ...
Mishra, Avinash, Rathore, Anurag S.
openaire   +3 more sources

Oxygen‐Tolerant Photo‐Induced Miniaturized Accelerated Atom Transfer Radical Polymerization (OPTIMA‐ATRP) for High‐Throughput Synthesis of Polymer Bioconjugates

Angewandte Chemie, EarlyView.
Oxygen‐tolerant photo‐induced miniaturized accelerated atom transfer radical polymerization (OPTIMA‐ATRP) in water was developed for the polymerization of hydrophilic (meth)acrylate monomers under ambient or sub‐ambient (4°C) temperature and atmospheric conditions, without prior degassing, in less than 10 min, at an ultra‐small scale (< 50 µL) in ...
Arman Moini Jazani, Roksana Wygoda, Hironobu Murata, Mozhdeh Madadi, Grzegorz Przesławski, Krzysztof Matyjaszewski   +5 more
wiley   +2 more sources

RdRp-based sensitive taxonomic classification of RNA viruses for metagenomic data [PDF]

Briefings in Bioinformatics, 2022
Abstract With advances in library construction protocols and next-generation sequencing technologies, viral metagenomic sequencing has become the major source for novel virus discovery. Conducting taxonomic classification for metagenomic data is an important means to characterize the viral composition in the underlying samples.
Xubo Tang, Jiayu Shang, Yanni Sun
openaire   +2 more sources

Targeting RdRp of SARS-CoV-2 with De Novo Molecule Generation

ACS Applied Bio Materials, 2023
Viruses are known for their extremely high mutation rates, allowing them to evade both the human immune system and many forms of standard medicine. Despite this, the RNA dependent RNA polymerase (RdRp) of the RNA viruses has been largely conserved, and any significant mutation of this protein is unlikely.
Amal Vijay, Venkata Sai Sreyas Adury, Arnab Mukherjee   +2 more
openaire   +2 more sources

The problem of SARS-CoV-2 virus resistance to direct-acting antivirals

Биопрепараты: Профилактика, диагностика, лечение
INTRODUCTION. The high prevalence of mutations in the SARS-CoV-2 genome raises particular concerns about the resistance of the virus to current antiviral therapy, including inhibitors of the main protease, or 3C-like protease (3CLpro), and RNA-dependent ...
E. L. Gasich, E. N. Krotkova, A. D. Kasko, K. Yu. Bulda, A. G. Krasko, E. A. Dorofeeva, I. A. Karpov   +6 more
doaj   +1 more source

Hantavirus RdRp Requires a Host Cell Factor for Cap Snatching [PDF]

Journal of Virology, 2019
Humans acquire hantavirus infection by the inhalation of aerosolized excreta of infected rodent hosts. Hantavirus infections cause hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS), with mortality rates of 15% and 50%, respectively (1).
Subbiah, Jeeva, Sheema, Mir, Adrain, Velasquez, Brandy A, Weathers, Aljona, Leka, Sharon, Wu, Ariga Tahmasian, Sevarany, Mohammad, Mir   +7 more
openaire   +2 more sources

Cu(0)-RDRP of styrene: balancing initiator efficiency and dispersity [PDF]

Polymer Chemistry, 2018
The optimisation of all components within Cu(0)-wire mediated polymerisation of styrene is illustrated yielding well-defined polystyrene with enhanced initiator efficiency and dispersity at higher molecular weights.
Richard Whitfield, Athina Anastasaki, Glen R. Jones, David M. Haddleton   +3 more
openaire   +3 more sources

Natural plant products as potential inhibitors of RNA dependent RNA polymerase of Severe Acute Respiratory Syndrome Coronavirus-2.

PLoS ONE, 2021
Drug repurposing studies targeting inhibition of RNA dependent RNA polymerase (RdRP) of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) have exhibited the potential effect of small molecules.
Shruti Koulgi, Vinod Jani, Mallikarjunachari Uppuladinne V N, Uddhavesh Sonavane, Rajendra Joshi   +4 more
doaj   +1 more source

Near‐Infrared Light‐Induced Reversible Deactivation Radical Polymerization: Expanding Frontiers in Photopolymerization

Advanced Science, 2023
Photoinduced reversible deactivation radical polymerization (photo‐RDRP) or photoinduced controlled/living radical polymerization has emerged as a versatile and powerful technique for preparing functional and advanced polymer materials under mild ...
Zilong Wu, Cyrille Boyer
doaj   +1 more source

DMS‐MaPseq and DREEM Analyses Implicate the Critical Role of RNA Structural Dynamics in Turnip Yellow Mosaic Virus Pathogenicity

Advanced Science, EarlyView.
RNA structural profiling of Turnip Yellow Mosaic Virus by DMS‐MaPseq and DREEM analyses uncover that viral genome‐wide RSS is highly complicated and heterogeneous, with alternative RSSs widely distributed across the genome. Notably, the viral 3’ tRNA‐like structure adopts alternative conformations in vivo.
Jiaying Zhu, Changhao Li, Chisimbily Onyia, Xindi Li, Xingxing Yan, Songxiao Zhong, Taerin Oh, Xiuren Zhang   +7 more
wiley   +1 more source