Results 31 to 40 of about 46,334 (221)

Inhibition of HEV Replication by FDA-Approved RdRp Inhibitors

ACS Omega, 2023
Hepatitis E virus (HEV) is primarily a hepatotropic virus that is responsible for acute hepatitis E in the general population and for chronic hepatitis in immunocompromised individuals. In the absence of a globally accessible vaccine, pegylated interferon-α and ribavirin are the only antiviral agents available for the treatment of chronic patients.
Preeti Hooda, Mohammed Al-Dosari, Neha Sinha, Mohammad K. Parvez, Deepak Sehgal   +4 more
openaire   +3 more sources

Different Cases of SARS-CoV-2 Infection and Its Impact on Health and Economy with Special Emphasis on Antiviral Drug Targets

Journal of Pure and Applied Microbiology, 2020
COVID-19 caused by SARS-CoV-2 has not only issued a pandemic situation but also lead to economic disaster and unprecedented health emergency. Being a close relative of Bat corona-virus, SARS and MERS it’s structural and sequence similarity has abled ...
Hiran Kanti Santra, Debdulal Banerjee
doaj   +1 more source

Identifying Small-Molecule Inhibitors of SARS-CoV-2 RNA-Dependent RNA Polymerase by Establishing a Fluorometric Assay

Frontiers in Immunology, 2022
SARS-CoV-2 (severe acute respiratory syndrome coronavirus‐2), a member of the coronavirus family, appeared in 2019 and has caused the largest global public health and economic emergency in recent history, affecting almost all sectors of society. SARS-CoV-
Xiaoming Bai, Xiaoming Bai, Hongmin Sun, Hongmin Sun, Shuo Wu, Shuo Wu, Yuhuan Li, Yuhuan Li, Lifei Wang, Lifei Wang, Bin Hong, Bin Hong   +11 more
doaj   +1 more source

Unbiased RNA shotgun metagenomics in social and solitary wild bees detects associations with eukaryote parasites and new viruses [PDF]

, 2016
The diversity of eukaryote organisms and viruses associated with wild bees remains poorly characterized in contrast to the well-documented pathosphere of the western honey bee, Apis mellifera.
Braeckman, Bart, de Graaf, Dirk, De Smet, Lina, Schoonvaere, Karel, Smagghe, Guy, Vierstraete, Andy   +5 more
core   +3 more sources

Genetic characterization of Pepino mosaic virus isolates from Belgian greenhouse tomatoes reveals genetic recombination [PDF]

, 2008
Over a period of a few years, Pepino mosaic virus (PepMV) has become one of the most important viral diseases in tomato production worldwide. Infection by PepMV can cause a broad range of symptoms on tomato plants, often leading to significant financial ...
Bragard, C., Goen, K., Hanssen, I.M., Lievens, B., Paeleman, A., Thomma, B.P.H.J., Vanachter, A.C.R.C., Wittemans, L.P.F.   +7 more
core   +3 more sources

In silico investigation to identify potential small molecule inhibitors of the RNA-dependent RNA polymerase (RdRp) nidovirus RdRp-associated nucleotidyltransferase domain

Chemical Physics Letters, 2021
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA-dependent RNA polymerase (RdRp) is a promising target for antiviral drugs. In this study, a chemical library (n = 300) was screened against the nidovirus RdRp-associated nucleotidyltransferase (NiRAN) domain.
Eleni Pitsillou, Julia Liang, Helen Yu Meng Huang, Andrew Hung, Tom C. Karagiannis   +4 more
openaire   +2 more sources

Virtual screening of natural products as potential inhibitors of SARS-CoV-2 main protease, RNA-dependent RNA polymerase (RdRp) and Spike Protein: Database design, molecular docking and molecular dynamic study [PDF]

Avicenna Journal of Phytomedicine
Objective: COVID-19 is caused by the SARS-CoV-2 virus. In this study, around 300 herbal compounds were screened virtually to find the best anti-COVID-19 structures. Materials and Methods: An extensive search in electronic databases was done.
Motahareh Boozari, Zeinab Amiri Tehranizadeh, Hossein Hosseinzadeh   +2 more
doaj   +1 more source

Molecular Evolutionary Analyses of the RNA-Dependent RNA Polymerase (RdRp) Region and VP1 Gene in Human Norovirus Genotypes GII.P6-GII.6 and GII.P7-GII.6

Viruses, 2023
To understand the evolution of GII.P6-GII.6 and GII.P7-GII.6 strains, the prevalent human norovirus genotypes, we analysed both the RdRp region and VP1 gene in globally collected strains using authentic bioinformatics technologies.
Tomoko Takahashi, Ryusuke Kimura, Tatsuya Shirai, Mitsuru Sada, Toshiyuki Sugai, Kosuke Murakami, Kazuhiko Harada, Kazuto Ito, Yuki Matsushima, Fuminori Mizukoshi, Kaori Okayama, Yuriko Hayashi, Mayumi Kondo, Tsutomu Kageyama, Yoshiyuki Suzuki, Haruyuki Ishii, Akihide Ryo, Kazuhiko Katayama, Kiyotaka Fujita, Hirokazu Kimura   +19 more
doaj   +1 more source

Initiation of RNA Polymerization and Polymerase Encapsidation by a Small dsRNA Virus. [PDF]

PLoS Pathogens, 2016
During the replication cycle of double-stranded (ds) RNA viruses, the viral RNA-dependent RNA polymerase (RdRP) replicates and transcribes the viral genome from within the viral capsid.
Aaron M Collier, Outi L Lyytinen, Yusong R Guo, Yukimatsu Toh, Minna M Poranen, Yizhi J Tao   +5 more
doaj   +1 more source

ICTV Virus Taxonomy Profile: Chrysoviridae [PDF]

, 2019
Members of the family Chrysoviridae are isometric, non-enveloped viruses with segmented, linear, dsRNA genomes. There are 3–7 genomic segments, each of which is individually encapsidated.
Castón, José R., Coutts, Robert, Hillman, Bradley I., ICTV Report Consortium, Jiang, Daohong, Kim, Dae-Hyuk, Kotta Loizou, Ioly, Moriyama, Hiromitsu, Suzuki, Nobuhiro   +8 more
core   +2 more sources