Results 31 to 40 of about 29,952 (187)

One‐Pot Synthesis of Aqueous PEDOT‐Based Conductive Inks via Sequential RAFT/Oxidative Polymerization

Angewandte Chemie, EarlyView.
We developed a fast, aqueous one‐pot synthesis for PEDOT:PSTFSI, combining sequential reversible addition–fragmentation chain‐transfer (RAFT) and oxidative polymerization. This method eliminates toxic solvents and purification steps, achieving full monomer conversion in under 3 h.
Fantine Negny, Melanie Bousquet, Benjamin Cabannes‐Boué, Pierre‐Yves Dugas, Lionel Hirsch, Thiago R. Guimaraes, Eric Cloutet   +6 more
wiley   +2 more sources

RdRp-based sensitive taxonomic classification of RNA viruses for metagenomic data [PDF]

Briefings in Bioinformatics, 2022
Abstract With advances in library construction protocols and next-generation sequencing technologies, viral metagenomic sequencing has become the major source for novel virus discovery. Conducting taxonomic classification for metagenomic data is an important means to characterize the viral composition in the underlying samples.
Xubo Tang, Jiayu Shang, Yanni Sun
openaire   +3 more sources

Effect of Genomic and Amino Acid Sequence Mutation on Virulence and Therapeutic Target of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS COV-2)

Infection and Drug Resistance, 2021
Endriyas Kelta Wabalo, Abebe Dukessa Dubiwak, Mengistu Welde Senbetu, Tariku Sime Gizaw Department of Biomedical Sciences, Faculty of Medical Sciences, Institute of Health, Jimma University, Jimma, EthiopiaCorrespondence: Endriyas Kelta WabaloDepartment ...
Kelta Wabalo E, Dukessa Dubiwak A, Welde Senbetu M, Sime Gizaw T   +3 more
doaj  

Cu(0)-RDRP of styrene: balancing initiator efficiency and dispersity [PDF]

Polymer Chemistry, 2018
The optimisation of all components within Cu(0)-wire mediated polymerisation of styrene is illustrated yielding well-defined polystyrene with enhanced initiator efficiency and dispersity at higher molecular weights.
Richard Whitfield, Athina Anastasaki, Glen R. Jones, David M. Haddleton   +3 more
openaire   +3 more sources

The problem of SARS-CoV-2 virus resistance to direct-acting antivirals

Биопрепараты: Профилактика, диагностика, лечение
INTRODUCTION. The high prevalence of mutations in the SARS-CoV-2 genome raises particular concerns about the resistance of the virus to current antiviral therapy, including inhibitors of the main protease, or 3C-like protease (3CLpro), and RNA-dependent ...
E. L. Gasich, E. N. Krotkova, A. D. Kasko, K. Yu. Bulda, A. G. Krasko, E. A. Dorofeeva, I. A. Karpov   +6 more
doaj   +1 more source

Targeting RdRp of SARS-CoV-2 with De Novo Molecule Generation

ACS Applied Bio Materials, 2023
Viruses are known for their extremely high mutation rates, allowing them to evade both the human immune system and many forms of standard medicine. Despite this, the RNA Dependent RNA Polymerase (RdRp) of the RNA viruses has been largely conserved, and any significant mutation to this protein is unlikely.
Amal Vijay, Venkata Sai Sreyas Adury, Arnab Mukherjee   +2 more
openaire   +2 more sources

Hantavirus RdRp Requires a Host Cell Factor for Cap Snatching [PDF]

Journal of Virology, 2019
Humans acquire hantavirus infection by the inhalation of aerosolized excreta of infected rodent hosts. Hantavirus infections cause hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS), with mortality rates of 15% and 50%, respectively (1).
Subbiah, Jeeva, Sheema, Mir, Adrain, Velasquez, Brandy A, Weathers, Aljona, Leka, Sharon, Wu, Ariga Tahmasian, Sevarany, Mohammad, Mir   +7 more
openaire   +2 more sources

Analysis of RdRp Gene in SARS CoV-2 Variants

International Journal of Research and Review, 2023
SARS CoV-2 was discovered in Wuhan, China, in December 2019 and has since mutated into new variants. One of the genes that mutated in SARS CoV-2 is RNA-dependent RNA polymerase (RdRp), a gene playing roles in viral replication and transcription. This study aimed to determine the variation of the RdRp gene in the SARS CoV-2 variant.
SM Rezvi, Desmawati Desmawati, Andani Eka Putra   +2 more
openaire   +1 more source

Mutations in RNA‐dependent RNA polymerase could be major cause of high pandemic potential of SARS‐CoV‐2: An in‐silico study

Indonesian Journal of Biotechnology
Human coronaviruses (HCoVs) are responsible for mild common cold to severe pneumonia‐like symptoms in infected individuals. The first HCoV was HCoV‐229E, discovered in 1962 in the US, which causes moderate symptoms.
Bhawna Sharma, Bennet Angel, Annette Angel, Vinod Joshi, Shareef Mohammed Buvvaji, Neha Singh, Khushbu Kumari, Aarya Chitransh, Poorna Khaneja, Devendra Kumar   +9 more
doaj   +1 more source

Crystallisation of Zika NS5 RdRp v1

The main aim of this work was to identify small molecules that bind Zika NS5 RdRp (catalytic RNA-dependent RNA polymerase domain) through X-ray fragment-based screening. The Zika NS5 RDRP domain was cloned, expressed, purified, and crystallised. Suitable crystals for fragment screening were produced and optimised allowing an extensive fragment ...
Anu V. Chandran, Peter Marples, Martin austin Walsh   +2 more
openaire   +2 more sources