Scientific ReportsThe COVID-19 pandemic, caused by SARS-CoV-2, has intensified the search for effective antiviral agents. This study investigates the inhibitory potential of 473 flavonoids from the genus Erythrina against the key enzyme of SARS-CoV-2, RNA-dependent RNA ...
Tati Herlina +6 more
doaj +1 more source
Pairwise comparison of ORF1 (RdRP) between AthCV1 and its closely related chrysoviruses.
, 2018 Pairwise comparison of ORF1 (RdRP) between AthCV1 and its closely related chrysoviruses.
Michael N. Pearson (6107363) +3 more
core +1 more source
Structure-Based Virtual Screening of Antiviral Compounds Targeting the Norovirus RdRp Protein [PDF]
Background: Human noroviruses (NV) are the primary etiological organisms causing acute gastroenteritis around the world, causing severe morbidity and imposing a significant economic burden.
Alzahrani, Abdulrahman +8 more
core +1 more source
Packaged, catalytically active RdRp is necessary for an early event in the replicative cycle.
, 2013 A. BSR-T7/5 cells were transfected with genome and all of the structural proteins (WT), or one or more of the components was replaced with an equivalent amount of empty vector (-Gn/Gc and –RdRp) or with plasmids expressing mutant alleles of Gn or RdRp ...
Dorothy R. Sorenson (354497) +2 more
core +1 more source
, 2008 Sesbania mosaic virus (SeMV) belongs to the genus sobemovirus and it infects sesbania grandiflora pers agathi. SeMV is a single stranded positive sense RNA virus, with 5\’ end of the genome covalently-linked viral protein called VPg (viral protein genome
Govind, K, Savithri, HS
core
Opportunities for dual RDRP agents in synthesizing novel polymeric materials
, 2017 Dual RDRP agents provide access to new polymeric materials by combining ATRP, NMP, and RAFT polymerization without end group transformations.
Samuel Pearson +7 more
core +1 more source
Tertiary structures of RNA-dependent RNA polymerase (RdRp).
, 2014 (A) The tertiary structure of RdRp for the pathogenic strain Dalnegorsk. (B) The tertiary structure of RdRp for the Sfd strain Primorye-270. In both models, the various subdomains are colored as follows: blue – fingers, green – palm, and pink – thumb ...
Sergei I. Belikov (552980) +3 more
core +1 more source
RdRp activity test using CRISPR/Cas13a enzyme (RACE) for screening of SARS-CoV-2 inhibitors
The coronavirus disease 2019 pandemic has highlighted the need for efficient antiviral drug screening tech-nologies, particularly for targeting RNA-dependent RNA polymerase (RdRp).
Taejoon Kang +13 more
core +1 more source
Faecal Viromes of Three Sympatric Penguins on Ardley Island, Antarctica: A Transcriptomic Study Showing Limited Host-Species Effect. [PDF]
VirusesXu R +11 more
europepmc +1 more source
Development and Application of a Dual-Fluorescent Reporter Assay for Feline Infectious Peritonitis Virus RNA-Dependent RNA Polymerase Inhibitor Screening. [PDF]
Int J Mol SciSemkum P +6 more
europepmc +1 more source