Results 111 to 120 of about 46,334 (221)

ssRNA bacteriophage metagenomes reveal a diverse set of novel protein families

Protein Science, Volume 35, Issue 5, May 2026.
Abstract The bacteriophages with single‐stranded RNA (ssRNA) genomes (class Leviviricetes) are among the simplest known viruses that encode only three core proteins: a receptor‐binding protein, a capsid protein, and an RNA‐dependent RNA polymerase. The number of isolated ssRNA phages has remained very low, but the accumulating RNA metagenome data have ...
Jānis Rūmnieks, Ieva Baltā, Mihails Šišovs, Kaspars Tārs   +3 more
wiley   +1 more source

Identification, Molecular Characterization, and Biology of a Novel Quadrivirus Infecting the Phytopathogenic Fungus Leptosphaeria biglobosa. [PDF]

, 2018
Here we report the molecular characterisation of a novel dsRNA virus isolated from the filamentous, plant pathogenic fungus Leptosphaeria biglobosa and known to cause significant alterations to fungal pigmentation and growth and to result in ...
Coutts, Robert, Fitt, Bruce, Kotta-Loizou, Ioly, Shah, Unnati   +3 more
core   +2 more sources

Molecular Evolutionary Analyses of the RNA-Dependent RNA Polymerase Region in Norovirus Genogroup II

Frontiers in Microbiology, 2018
Noroviruses are the leading cause of viral gastroenteritis in humans across the world. RNA-dependent RNA polymerase (RdRp) plays a critical role in the replication of the viral genome.
Keita Ozaki, Keita Ozaki, Yuki Matsushima, Koo Nagasawa, Takumi Motoya, Akihide Ryo, Makoto Kuroda, Kazuhiko Katayama, Hirokazu Kimura, Hirokazu Kimura   +9 more
doaj   +1 more source

Evidence for RNA recombination between distinct isolates of Pepino mosaic virus. [PDF]

, 2010
Genetic recombination plays an important role in the evolution of virus genomes. In this study we analyzed publicly available genomic sequences of Pepino mosaic virus (PepMV) for recombination events using several bioinformatics tools.
Hasiów-Jaroszewska, B., Kuzniar, A., Leunissen, J.A.M., Peters, S.A., Pospieszny, H.   +4 more
core   +1 more source

Interference of small compounds and Mg2+ with dsRNA-binding fluorophores compromises the identification of SARS-CoV-2 RdRp inhibitors

Scientific Reports
The COVID-19 pandemic highlighted the need for the rapid development of antiviral therapies. Viral RNA-dependent RNA polymerases (RdRp) are promising targets, and numerous virtual screenings for potential inhibitors were conducted without validation of ...
Susana Llanos, Bruno Di Geronimo, Ester Casajús, Elena Blanco-Romero, Rafael Fernández-Leiro, Juan Méndez   +5 more
doaj   +1 more source

Template-directed biopolymerization: tape-copying Turing machines

, 2012
DNA, RNA and proteins are among the most important macromolecules in a living cell. These molecules are polymerized by molecular machines. These natural nano-machines polymerize such macromolecules, adding one monomer at a time, using another linear ...
Chowdhury, Debashish, Sharma, Ajeet K.
core   +1 more source

Identification and sequence determination of a novel double-stranded RNA mycovirus from the entopathogenic fungus Beauveria bassina [PDF]

, 2015
The final publication is available at Springer via https://doi.org/10.1007/s00705-014-2332-8.An isolate of the entomopathogenic fungus Beauveria bassiana was found to contain five double-stranded (ds) RNA elements ranging from 1.5 to more than 3 kbp. The
Coutts, Robert H.A., Kotta-Loizou, I., Sipkova, J.   +2 more
core   +1 more source

NeoRdRp2 with improved seed data, annotations, and scoring

Frontiers in Virology
RNA-dependent RNA polymerase (RdRp) is a marker gene for RNA viruses; thus, it is widely used to identify RNA viruses from metatranscriptome data. However, because of the high diversity of RdRp domains, it remains difficult to identify RNA viruses using ...
Shoichi Sakaguchi, Takashi Nakano, So Nakagawa, So Nakagawa, So Nakagawa   +4 more
doaj   +1 more source

Tomato Spotted Wilt Virus Reprogrammes Host Glycolysis to Facilitate Proliferation by a Phase‐Separated Co‐Aggregate of Nucleocapsid Protein and Phosphoglycerate Kinase

Plant Biotechnology Journal, Volume 24, Issue 5, Page 2826-2842, May 2026.
ABSTRACT Efficient viral proliferation within the host is a critical step in pathogenicity and requires adenosine triphosphate (ATP). The replication, movement and immune evasion of many plant viruses within their hosts are associated with phase separation (PS)‐derived aggregates formed by viral components.
Guangcheng Zu, Zhifu Xing, Jiao Li, Tangbing Yang, Huan Wu, Qiangsheng Ge, Yanju Wang, Baoan Song, Runjiang Song   +8 more
wiley   +1 more source

The modeled structure of the RNA dependent RNA polymerase of GBV-C Virus suggests a role for motif E in Flaviviridae RNA polymerases

BMC Bioinformatics, 2005
Background The Flaviviridae virus family includes major human and animal pathogens. The RNA dependent RNA polymerase (RdRp) plays a central role in the replication process, and thus is a validated target for antiviral drugs.
Dutartre Hélène, Bussetta Cécile, Ferron François, Canard Bruno   +3 more
doaj   +1 more source