Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Microscopic basis of reaction center modulation in PsbA variants of photosystem II. [PDF]
Bhattacharjee S +3 more
europepmc +1 more source
Spatial Separation of Plasmonic Hot-Electron Generation and a Hydrodehalogenation Reaction Center Using a DNA Wire. [PDF]
Kogikoski S, Dutta A, Bald I.
europepmc +1 more source
100 Glimpses is a series of short documentaries produced by the Sight Center of Northwest Ohio. The series explores the organization's history. The Sight Center was founded in 1923 as the Toledo Society for the Blind.
Sight Center of Northwest Ohio (Toledo, Ohio)
core
PANoptosis in the pathogenesis of myelodysplastic syndromes
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Barrierless Electron Transfer in a Photosynthetic Reaction Center Model. [PDF]
Ullrich T +3 more
europepmc +1 more source
100 Glimpses is a series of short documentaries produced by the Sight Center of Northwest Ohio. The series explores the organization's history. The Sight Center was founded in 1923 as the Toledo Society for the Blind.
Sight Center of Northwest Ohio (Toledo, Ohio)
core
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
The Recombination Triplet State in the Far-Red Light Adapted Photosystem II Is Located at the Chl<sub>D1</sub> Site and Resides on the Red-Most Chlorophyll of the Reaction Center. [PDF]
Calcinoni A +5 more
europepmc +1 more source
X-ray structure of the Rhodobacter sphaeroides reaction center with an M197 Phe→His substitution clarifies the properties of the mutant complex. [PDF]
Selikhanov G +5 more
europepmc +1 more source

