Advanced Science, EarlyView.Snord17, through interaction with Thoc3, promotes nuclear export and translation of Yy2 mRNA in Snord17+/+ ISCs. The Yy2 protein subsequently binds the Tead4 promoter to promote its transcription, activating Hippo signaling, which is essential for ISC maintenance.
Peikang Zhang +10 more
wiley +1 more source
Advanced Science, EarlyView.Mutant p53 drives oncogenic splicing to promote the progression of ovarian cancer by partnering with the spliceosome factor SNRPD2. Therefore, it is engineered iRGD‐exosomes to co‐deliver siRNAs against both targets. This approach restored tumor‐suppressive mRNA isoforms, effectively enhanced sensitivity to cisplatin, and ultimately blocked tumor ...
Wei Zhao +14 more
wiley +1 more source
BRCA2 Status Alters the Effect of the P53 Reactivator HO-3867 in Ovarian Cancer Cells. [PDF]
J Cancer Sci Clin Ther, 2023 Devor EJ, Thomas AE, Schickling BM.
europepmc +1 more source
An Optimal Oscillatory Phase for Pattern Reactivation during Memory Retrieval
, 2018 Casper Kerrén +3 more
openalex +1 more source
Hepatitis B virus reactivation during severe acute respiratory syndrome coronavirus-2 infection
, 2022 Tyng‐Yuan Jang
openalex +1 more source
T cell-extrinsic IL-1 signaling controls long-term gammaherpesvirus infection by suppressing viral reactivation [PDF]
, 2022 P. A. Sylvester +2 more
openalex +1 more source
Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating β‐Thalassemia
Advanced Science, EarlyView.Context of Research: β‐thalassemia affects millions worldwide. DNMT inhibitors are effective HbF‐inducers that benefit patients with β‐thalassemia. Existing DNMT inhibitors are not approved for β‐thalassemia treatment due to dose‐limiting toxicity.What We Find: DMT207 traps DNMT1 into helix‐kinked inactive conformation and enhances its interaction with
Yijie Shen +19 more
wiley +1 more source
The human brain reactivates context-specific past information at event boundaries of naturalistic experiences [PDF]
, 2022 Avital Hahamy +2 more
openalex +1 more source
Ionic–Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy
Advanced Science, EarlyView.Ionic–bionic interfaces for bioelectronics leverage ions as multifunctional mediators that combine mechanical compliance, ionic and electronic functionalities, and therapeutic effects. These systems offer real‐time biosignal transduction, effective wound dressing, responsive drug delivery, and seamless interaction between soft tissues and electronic ...
Yun Goo Ro +6 more
wiley +1 more source
Biosensors based on cholinesterase inhibition for insecticides, nerve agents and aflatoxin B1 detection (review) [PDF]
, 2010 Amine, A +3 more
core +1 more source