Results 11 to 20 of about 26,803 (327)

PK11007 Covalently Inhibits Thioredoxin Reductase 1 to Induce Oxidative Stress and Autophagy Impairment in NSCLC Cells [PDF]

Antioxidants
Selenoprotein thioredoxin reductase 1 (TXNRD1) is frequently upregulated in various cancer cells to sustain cellular redox homeostasis, and its inhibition has emerged as a promising anti-cancer strategy.
Hanziyi Zhou, Shibo Sun, Haowen Liu, Tong Li, Yiran Xu, Rui Yang, Haiyan Liu, Leiyu He, Weiping Xu, Shui Guan, Jianqiang Xu   +10 more
doaj   +2 more sources

Cholesterol Oxime Olesoxime Assessed as a Potential Ligand of Human Cholinesterases [PDF]

Biomolecules
Olesoxime, a cholesterol derivative with an oxime group, possesses the ability to cross the blood–brain barrier, and has demonstrated excellent safety and tolerability properties in clinical research.
Dora Kolić, Goran Šinko, Ludovic Jean, Mourad Chioua, José Dias, José Marco-Contelles, Zrinka Kovarik   +6 more
doaj   +2 more sources

MIRA-1, a p53mut reactivator, is active on Temozolomide-resistant glioblastoma in vitro [PDF]

Molecular Biomedicine
Juan Perdomo, Catherine Gratas, François Paris, Francois M. Vallette, Lisa Oliver   +4 more
doaj   +2 more sources

EFFECTIVENESS OF DECOY WATER TREATMENT ON REACTIVATORS AT PT GOODYEAR INDONESIA Tbk

Al-Ulum, 2023
PT Goodyear Indonesia Tbk is a tire manufacturing industry whose main need is the provision of water for steam boiler decoys. This water is obtained from groundwater and surface water such as river water which is then treated in a reactivator using one ...
Sri Murda Niati, Guruh Akbar, Gemala Cahya   +2 more
doaj   +1 more source

APR-246—The Mutant TP53 Reactivator—Increases the Effectiveness of Berberine and Modified Berberines to Inhibit the Proliferation of Pancreatic Cancer Cells

Biomolecules, 2022
Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer. In ~75% of PDAC, the tumor suppressor TP53 gene is mutated. Novel approaches to treat cancer involve compounds called mutant TP53 reactivators.
James Andrew McCubrey, Stephen L. Abrams, Linda S. Steelman, Lucio Cocco, Stefano Ratti, Alberto M. Martelli, Paolo Lombardi, Agnieszka Gizak, Przemysław Duda   +8 more
doaj   +1 more source

AI-powered discovery of a novel p53-Y220C reactivator

Frontiers in Oncology, 2023
IntroductionThe p53-Y220C mutation is one of the most common mutations that play a major role in cancer progression.MethodsIn this study, we applied artificial intelligence (AI)-powered virtual screening to identify small-molecule compounds that ...
Shan Zhou, Dafei Chai, Xu Wang, Praveen Neeli, Xinfang Yu, Aram Davtyan, Ken Young, Yong Li   +7 more
doaj   +1 more source

Effects of the Mutant TP53 Reactivator APR-246 on Therapeutic Sensitivity of Pancreatic Cancer Cells in the Presence and Absence of WT-TP53

Cells, 2022
The TP53 tumor suppressor is mutated in ~75% of pancreatic cancers. The mutant TP53 protein in pancreatic ductal adenocarcinomas (PDAC) promotes tumor growth and metastasis.
Stephen L. Abrams, Przemysław Duda, Shaw M. Akula, Linda S. Steelman, Matilde L. Follo, Lucio Cocco, Stefano Ratti, Alberto M. Martelli, Giuseppe Montalto, Maria Rita Emma, Melchiorre Cervello, Dariusz Rakus, Agnieszka Gizak, James A. McCubrey   +13 more
doaj   +1 more source

Targeted Synthesis of 1-(4-Hydroxyiminomethylpyridinium)-3-pyridiniumpropane Dibromide – A New Nerve Agent Reactivator

Molecules, 2007
Preparation of 1-(4-hydroxy-iminomethylpyridinium)-3-pyridiniumpropane dibromide is described. This compound represents a new acetylcholinesterase (AChE) reactivator, which has no substituents on the second pyridinium ring as found in other commonly used
Jan Marek, Martina Hrabinova, Petr Stodulka, Daniel Jun, Martin Paar, Kamil Musilek, Kamil Kuca   +6 more
doaj   +1 more source

Transitioning from Oxime to the Next Potential Organophosphorus Poisoning Therapy Using Enzymes

Journal of Chemistry, 2021
For years, organophosphorus poisoning has been a major concern of health problems throughout the world. An estimated 200,000 acute pesticide poisoning deaths occur each year, many in developing countries.
Rauda A. Mohamed, Keat K. Ong, Noor Azilah M. Kasim, Norhana A. Halim, Siti Aminah M. Noor, Victor F. Knight, Nurul Najwa Ab. Rahman, Wan Md Zin W. Yunus   +7 more
doaj   +1 more source

Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1:a novel anticancer small-molecule [PDF]

, 2015
Restoration of the p53 pathway, namely by reactivation of mutant (mut) p53, represents a valuable anticancer strategy. Herein, we report the identification of the enantiopure tryptophanol-derived oxazoloisoindolinone SLMP53-1 as a novel reactivator of ...
Bessa, Cláudia, Bisio, Alessandra, Fernandes, João, Gomes, Célia, Gomes, Sara, Gonçalves, Jorge, Inga, Alberto, Monteiro, Ângelo, Pereira, Clara, Pereira, Nuno A.L., Queiroz, Glória, Raimundo, Liliana, Reis, Flávio, Santos, Maria M.M., Saraiva, Lucília, Soares, Joana   +15 more
core   +3 more sources