Results 31 to 40 of about 124,194 (317)

Causal Therapy of Alkylphosphate Poisoning [PDF]

, 1957
We have designed to apply 2-pyridine aldoxime methiodide(PAM), considered to be a cholinesterase reactivator in vitro, both to the laboratory rabbits poisoned by parathion and to the patients of parathion poisoning, and obtained the following results: 1.
Hiraki, Kiyoshi, Namba, Tatsuji
core   +1 more source

Novel Bisquaternary Oximes—Reactivation of Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon

Molecules, 2009
Four novel bisquaternary aldoxime cholinesterase reactivators differing in their chemical structure were prepared. Afterwards, their biological activity was evaluated for their ability to reactivate acetylcholinesterase (AChE; EC 3.1.1.7) and ...
Daniel Jun, Jana Zdarova Karasova, Miroslav Pohanka, Martina Hrabinova, Kamil Musilek, Martin Paar, Vladimir Cirkva, Jiri Palecek, Kamil Kuca, Lucie Musilova   +9 more
doaj   +1 more source

Nanoparticulate transport of oximes over an in vitro blood-brain barrier model [PDF]

, 2010
Background: Due to the use of organophosphates (OP) as pesticides and the availability of OP-type nerve agents, an effective medical treatment for OP poisonings is still a challenging problem.
Wagner, Sylvia, Kufleitner, Jürgen, Zensi, Anja, Dadparvar, Miriam, Wien, Sascha, Bungert, Judith, Vogel, Tikva, Worek, Franz, Kreuter, Jörg (Prof. Dr.), Briesen, Hagen von   +9 more
core   +2 more sources

Molecular modeling studies on the multistep reactivation process of organophosphate-inhibited acetylcholinesterase and butyrylcholinesterase [PDF]

, 2021
Poisoning with organophosphorus compounds used as pesticides or misused as chemical weapons remains a serious threat to human health and life.
Bajda, Marek, Jończyk, Jakub, Jung, Young-Sik, Kukułowicz, Jędrzej, Malawska, Barbara, Musilek, Kamil, Łątka, Kamil   +6 more
core   +1 more source

Zn(II)-curc targets p53 in thyroid cancer cells [PDF]

, 2015
P53 mutation is a common event in many cancers, including thyroid carcinoma. Defective p53 activity promotes cancer resistance to therapies and a more malignant phenotype, acquiring oncogenic functions.
Crispini, Alessandra, D'Orazi, Gabriella, D'Orazi, Valerio, Garufi, Alessia   +3 more
core   +2 more sources

Small molecule induced reactivation of mutant p53 in cancer cells [PDF]

, 2013
The p53 cancer mutant Y220C is an excellent paradigm for rescuing the function of conformationally unstable p53 mutants because it has a unique surface crevice that can be targeted by small-molecule stabilizers.
Adams, Alan R. Fersht, Andreas C. Joerger, Boeckler, Brown, Bullock, Bullock, Chipuk, Chuckowree, Cook, Dearth, Di Como, Emsley, Endo, Foster, Gannon, Green, Hengartner, Irina S. Chuckowree, Jahangir Amin, Joerger, Joerger, Joerger, Joerger, John Spencer, Johnson, Kaar, Kabsch, Kojima, Kojima, Lambert, Lane, Legros, Leslie, Liu, Newhouse, Oda, Petitjean, Rainer Wilcken, Rippin, Speidel, Spencer, Spencer, Spencer, Spencer, Spencer, Taylor, Van Maerken, Vassilev, Villunger, Vousden, Walerych, Wang, Wattel, Wilcken, Wilcken, Wolter, Xiangrui Liu, Yu   +58 more
core   +2 more sources

Reactive arthritis

European Journal of Case Reports in Internal Medicine
Reactive arthritis is a form of seronegative spondylarthritis that presents following an infection, with clear associations to specific microorganisms. It is a rare entity and typically affects young adults. An 88-year-old woman, admitted in our ward with pseudomembranous enterocolitis and acute renal lesion, presented with axial oligoarthritis on the ...
Carolina António Santos, Frederico Trigueiros, Inês Machado Leite   +2 more
openaire   +6 more sources

Reactivation Potency of New Group of Acetylcholinesterase Reactivators and Their Comparison with Currently Available Oximes

Acta Medica, 2006
In this work, in vitro potency of novel serie of monoquaternary pyridinium oximes to reactivate cyclosarin-inhibited acetylcholinesterase (AChE) was tested.
Kamil Kuča, Jan Pícha, Daniel Jun
doaj   +1 more source

Development of a Larval Zebrafish Model for Acute Organophosphorus Nerve Agent and Pesticide Exposure and Therapeutic Evaluation

Toxics, 2020
Organophosphorus compound exposure remains a present threat through agricultural accidents, warfare, or terrorist activity. The primary mechanism of organophosphorus toxicity is through inhibition of the enzyme acetylcholinesterase, with current ...
Jeffrey A. Koenig, Cindy Acon Chen, Tsung-Ming Shih   +2 more
doaj   +1 more source

The Synthetic Curcumin Analog HO-3867 Rescues Suppression of PLAC1 Expression in Ovarian Cancer Cells

Pharmaceuticals, 2021
Elevated expression of placenta-specific protein 1 (PLAC1) is associated with the increased proliferation and invasiveness of a variety of human cancers, including ovarian cancer.
Eric J. Devor, Brandon M. Schickling, Jace R. Lapierre, David P. Bender, Jesus Gonzalez-Bosquet, Kimberly K. Leslie   +5 more
doaj   +1 more source