Results 41 to 50 of about 1,554 (191)
Computational Design, Molecular Docking Study and Toxicity Prediction of Some Novel Pralidoxime Derivatives as reactivators of acetyl cholinesterase enzyme [PDF]
Journal of Advanced Biomedical Sciences, 2019 Background & Objective: oximes as Acetylcholinesterase (AChE) reactivators were developed for the treatment of organophosphate compounds (OPCs) intoxication.
abozar roeintan
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Acta Medica, 2004 We have tested four new bisquaternary pyridinium acetylcholinesterase (AChE; EC 3.1.1.7) reactivators – K005 (1,3–bis(2–hydroxyiminomethylpyridinium) propane dibromide), K033 (1,4–bis(2–hydroxyiminomethylpyridinium) butane dibromide), K027 (1–(4 ...
Kamil Kuča +2 more
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Counteracting poisoning with chemical warfare nerve agents
Arhiv za Higijenu Rada i Toksikologiju, 2020 Phosphylation of the pivotal enzyme acetylcholinesterase (AChE) by nerve agents (NAs) leads to irreversible inhibition of the enzyme and accumulation of neurotransmitter acetylcholine, which induces cholinergic crisis, that is, overstimulation of ...
Hrvat Nikolina Maček, Kovarik Zrinka
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Scientific Reports, 2021 Nerve agents have experienced a resurgence in recent times with their use against civilian targets during the attacks in Syria (2012), the poisoning of Sergei and Yulia Skripal in the United Kingdom (2018) and Alexei Navalny in Russia (2020), strongly ...
Brian J. Bennion +12 more
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The ganglionic blocking properties of the cholinesterase reactivator, HS-6
, 1978 Following intravenous administration of the cholinesterase reactivator HS-6 (30 mg/kg), blood pressure fell (up to 50 mmHg) and maximal blood levels of HS-6 reached 242 μg/ml. HS-6 attenuated the pressor response resulting from carotid occlusion and the
Paul M. Lundy
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Anticholinergic Drugs – Functional Antidotes for the Treatment of Tabun Intoxication
Acta Medica, 2004 Summary: 1. To study the influence of antidotes on tabun-induced neurotoxicity, the rats were injected intramuscularly with organophosphate tabun (LD50).
Gabriela Krejčová, Jiří Kassa
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Ethylene as catalyst reactivator in the propene-styrene copolymerization
, 1999 An experiment was conducted to show the presence of ethylene as catalyst reactivator in the propene-styrene copolymerization. The copolymerizations have been performed by bubbling the gaseous monomers at atmospheric pressure into a flask containing a ...
Izzo, L., Caporaso, L., Oliva, L.
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Productive reorientation of a bound oxime reactivator revealed in room temperature X-ray structures of native and VX-inhibited human acetylcholinesterase [PDF]
, 2019 Exposure to organophosphorus compounds (OPs) may be fatal if untreated, and a clear and present danger posed by nerve agent OPs has become palpable in recent years.
Kovalevsky, Andrey +7 more
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New Uncharged 2-Thienostilbene Oximes as Reactivators of Organophosphate-Inhibited Cholinesterases
Pharmaceuticals, 2021 The inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) by organophosphates (OPs) as nerve agents and pesticides compromises normal cholinergic nerve signal transduction in the peripheral and central nervous systems (CNS) leading ...
Milena Mlakić +8 more
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Acta Medica, 2001 1. The influence of anticholinergic drugs (atropine, benactyzine, biperiden) on the efficacy of monopyridinium and bispyridinium oximes (HI-6, BI-6, obidoxime, pralidoxime, methoxime) on soman-induced supralethal poisoning was studied in mice. 2.
Jiří Kassa
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