Results 61 to 70 of about 1,554 (191)

Identification of two metabolites of the cholinesterase reactivator HI-6 isolated from rat urine

, 1987
Two metabolites, isolated from the urine of rats given the cholinesterase reactivator HI-6 intravenously, still contained quaternary nitrogen atoms and therefore could not be extracted from aqueous solutions by organic solvents.
David A Ligtenstein, Simon P Kossen, Albert G Hulst, Eric R J Wils   +3 more
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Antidotal efficacy of newly synthesized oximes K203 and K027 in rats acutely exposed to dichlorvos [PDF]

, 2019
Standarna terapija akutnog trovanja ljudi organofosfornim (OF) jedinjenjoma sastoji se od leka sa aniholinergičkim efektom (atropin) i reaktivatora inhibirane acetilholinesteraze (AChE)(oksim)...Satndart therapy for acute human poisoning with ...
Antonijević, Evica
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Study of change of reactivation potency and also ability of penetration throught the blood-brain barrier of newly prepared (fluorinated) acetylcholinesterase reactivator [PDF]

, 2010
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Candidate: Ing. Pavel Jurczyk Supervisor: PharmDr. Marie Vopršalová, CSc.
Jurczyk, Pavel
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A Comparison of the Potency of the Oxime HLö-7 and Currently Used Oximes (HI-6, Pralidoxime, Obidoxime) to Reactivate Nerve Agent-Inhibited Rat Brain Acetylcholinesterase by in vitro Methods

Acta Medica, 2005
1. The efficacy of the oxime HLö-7 and currently used oximes (pralidoxime, obidoxime, HI-6) to reactivate acetylcholinesterase inhibited by various nerve agents (sarin, tabun, cyclosarin, VX) was tested by in vitro methods. 2. Both H oximes (HLö-7, HI-6)
Kamil Kuča, Jiří Cabal, Jiří Kassa, Daniel Jun, Martina Hrabinová   +4 more
doaj   +1 more source

Pharmacokinetics of acetylcholinesterase reactivator K203 and consequent evaluation of low molecular weight antioxidants/markers of oxidative stress

, 2012
Oxime K203 is a new compound designed to be used as an acetylcholinesterase reactivator for the treatment of intoxication following exposure to tabun and certain pesticides.
Miroslav Pohanka, Jana Žďárová Karasová, Kuča, K., Hnídková, D., Karasová, J.Z., Kamil Musílek, Kamil Kuča, Musílek, K., Daniela Hnídková, Robert Peter Chilcott, Chilcott, Robert, Pohanka, M.   +11 more
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Design of a Potent Reactivator of Tabun-Inhibited Acetylcholinesterase - Synthesis and evaluation of (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene Dibromide (K203)

, 2007
Acetylcholinesterase reactivators are crucial antidotes for the treatment of organophosphate intoxication. Among the organophosphates, with the exception of soman, tabun (GA) intoxications are the least responsive to treatment with commercially available
Kuca, K, Jun, D, Gunn-Moore, Francis James, Kassa, J, Cabal, J, Musilek, K   +5 more
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Molecular modeling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime, 4-PA, 2-PAM, and obidoxime with VX-inhibited human acetylcholinesterase: a near attack conformation approach

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
7-methoxytacrine-4-pyridinealdoxime (7-MEOTA-4-PA, named hybrid 5C) is a compound formerly synthesized and evaluated in vitro, together with 4-pyridine aldoxime (4-PA) and commercial reactivators of acetylcholinesterase (AChE). This compound was designed
Jorge Alberto Valle da Silva, Eugenie Nepovimova, Teodorico Castro Ramalho, Kamil Kuca, Tanos Celmar Costa França   +4 more
doaj   +1 more source

Design of a Potent Reactivator of Tabun-Inhibited AcetylcholinesteraseSynthesis and Evaluation of (E)-1-(4-Carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene Dibromide (K203)

, 2016
Acetylcholinesterase reactivators are crucial antidotes for the treatment of organophosphate intoxication. Among the organophosphates, with the exception of soman, tabun (GA) intoxications are the least responsive to treatment with commercially available
Frank Gunn-Moore (617350), Kamil Kuca (1474993), Jiri Kassa (1474996), Jiri Cabal (2470213), Kamil Musilek (1476094), Daniel Jun (1475023)   +5 more
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Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime

, 2020
International audienceBackground: Human exposure to organophosphorus compounds employed as pesticides or as chemical warfare agents induces deleterious effects due to cholinesterase inhibition.
Pascal Villa, André-Guilhem Calas, Charlotte Courageux, Jaffré, Nina, Obrecht, Adeline, Yerri, Jagadeesh, Anne-Sophie Hanak, Jean-François Goossens, Jagadeesh Yerri, Calas, André-Guilhem, Dias, José, Xavier Brazzolotto, José Dias, Catherine Rousseau, Hachani, Johan, Courageux, Charlotte, Maria Kliachyna, Johan Hachani, Florian Nachon, Brazzolotto, Xavier, Fabien Gosselet, Baati, Rachid, Rousseau, Catherine, Marie-Pierre Dehouck, Goossens, Jean-François, Adeline Obrecht, Christophe Landry, Hanak, Anne-Sophie, Gosselet, Fabien, Nervo, Aurélie, Landry, Christophe, Nachon, Florian, Dehouck, Marie-Pierre, Rachid Baati, Kliachyna, Maria, Aurélie Nervo, Nina Jaffré, Villa, Pascal   +37 more
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The Influence of the Time of Antidotal Treatment Administration on Its Effectiveness Against Tabun-Induced Poisoning in Mice

Acta Medica, 2004
Summary: 1. The influence of the time of administration of antidotal treatment consisting of anticholinergic drug (atropine) and oxime (pralidoxime, obidoxime, HI-6 or trimedoxime) on its effectiveness to eliminate tabun-induced lethal effects was ...
Jiří Kassa
doaj   +1 more source