Results 71 to 80 of about 1,554 (191)
مجلة بغداد للعلومPancreatic cancer (PC) is a disease with a high mortality rate, and the early diagnosis of PC is still challenging. The 5-year relative survival rate remains below 8%, and therapeutic strategies are ineffective at increasing patient survival rates.
Ali Haider Alhammer +2 more
doaj +1 more source
The Influence of Oxime Selection on the Efficacy of Antidotal Treatment of Soman-Poisoned Rats
Acta Medica, 2002 1. The influence of some acetylcholinesterase reactivators (HI-6, obidoxime, pralidoxime) on the efficacy of antidotal treatment to eliminate soman-induced disturbance of respiration and circulation and to protect experimental animals poisoned with ...
Jiří Kassa, Josef Fusek
doaj +1 more source
The pharmacokinetics of the oxime acetylcholinesterase reactivator K869
, 2021 Co-administration of oxime reactivators of AChE together with atropine and diazepam is the basic strategy for the pharmacological treatment of organophosphate (OP) poisoning.
Hojná, Anna
core
Pharmacokinetics and pharmacodynamics of an efficient acetylcholinesterase reactivator
, 2021 Acetilkolinesteraza (AChE; E.C. 3.1.1.7) je enzim intenzivno istraživan u području biokemije i toksikologije zbog svoje iznimne važnosti u homeostazi organizma.
Pavošević, Kristian
core
Postgraduate Medical Journal, 1982 AbstractReactive arthritis is a rare complication of certain infections. The similar features and HLA associations with the seronegative arthropathies have raised the possibility that the latter may be forms of reactive arthritis. This review describes the clinical and epidemiological features, and the recent advances in our understanding of the ...
openaire +2 more sources
Small-Molecule Reactivation of Mutant p53 to Wild-Type-like p53 through the p53-Hsp40 Regulatory Axis [PDF]
, 2015 SummaryTP53 is the most frequently mutated gene in human cancer, and small-molecule reactivation of mutant p53 function represents an important anticancer strategy. A cell-based, high-throughput small-molecule screen identified chetomin (CTM) as a mutant
Namba, Takushi +17 more
core +1 more source
, 2021 Prirodna niskotemperaturna eutektička otapala, nova zelena otapala, istražuju se kao alternativna otapala za otapanje djelatnih farmaceutskih tvari. Razvoj učinkovitog antidota za otrovanja organofosfornim (OP) spojevima, ireverzibilnim inhibitorima ...
Štokić, Marina
core +1 more source
Novel Group of AChE Reactivators—Synthesis, In Vitro Reactivation and Molecular Docking Study
Molecules, 2018 The acetylcholinesterase (AChE) reactivators (e.g., obidoxime, asoxime) became an essential part of organophosphorus (OP) poisoning treatment, together with atropine and diazepam.
David Malinak +4 more
doaj +1 more source
, 2018 Koh, John T.In chapter one, a new concept of catalytic acetyl transfer enzyme inhibitor design was explored. Thiolsalicylamide analogues were recently used to transfer acetyl group in vitro and in vivo to lysine/serine of target proteins. The ability of
Bao, Wei
core +1 more source
Preparation of Oxime HI-6 (Dichloride and Dimethanesulphonate)ŒAntidote against Nerve Agents [PDF]
, 2008 Because of the threat of misuse of nerve agents as terroristic weapons by the terrorists, animmediate need is felt for the preparation of antidotes on large-scale basis.
Stodulka, Petr +5 more
core +1 more source