Results 81 to 90 of about 1,554 (191)

Review on Abyssomicins: Inhibitors of the Chorismate Pathway and Folate Biosynthesis

Molecules, 2018
Antifolates targeting folate biosynthesis within the shikimate-chorismate-folate metabolic pathway are ideal and selective antimicrobials, since higher eukaryotes lack this pathway and rely on an exogenous source of folate.
Carmen Sadaka, Edmund Ellsworth, Paul Robert Hansen, Richard Ewin, Peter Damborg, Jeffrey L. Watts   +5 more
doaj   +1 more source

Avanços sobre a neurotoxicidade induzida pelo pesticida organofosforado malation em modelos experimentais com camundongos [PDF]

, 2007
Dissertação (mestrado) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Programa de Pós-Graduação em NeurociênciasO pesticida organofosforado (OF) Malation é um composto utilizado como inseticida em áreas urbanas e rurais. Sabe-se
Silva, Aline Preve da
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In vivo evaluation of the efficacy of the novel reactivator against tabun

, 2020
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Candidate: Natália Kuzmiaková Supervisor: PharmDr. Marie Vopršalová, CSc . Consultant: mjr. PharmDr. Vendula Hepnarová, Ph.D.
Kuzmiaková, Natália
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Efeito reativador de oximas frente à inibição da enzima acetilcolinesterase cerebral induzida pelo malation e malaoxon [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Bioquímica, Florianópolis, 2009.O malation e um pesticida organofosforado (OF) e sua toxicidade depende da sua bioativacao a ...
Santos, Alessandra Antunes dos
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Oxime-dipeptides as anticholinesterase, reactivator of phosphonylated-serine of AChE catalytic triad: probing the mechanistic insight by MM-GBSA, dynamics simulations and DFT analysis

, 2015
Neuropathological cascades leading to reduced cholinergic transmission in Alzheimer’s disease led to development of AChE-inhibitors. Although lethal dose of some inhibitors cause interruption with AChE mediated mechanism but reversible AChE inhibitors ...
Anil K. Mishra (569351), Marilyn D. Milton (569350), Nidhi Chadha (569347), Anjani K. Tiwari (569348), Sangeeta Lal (569349), Vikas Kumar (153353)   +5 more
core   +1 more source

Mixed cationic liposomes for brain delivery of drugs by the intranasal route: The acetylcholinesterase reactivator 2-PAM as encapsulated drug model [PDF]

, 2018
© 2018 Elsevier B.V. New mixed cationic liposomes based on L-α-phosphatidylcholine and dihexadecylmethylhydroxyethylammonium bromide (DHDHAB) were designed to overcome the BBB crossing by using the intranasal route.
Lukashenko S., Pashirova T., Souto E., Almasy L., Kulik N., Masson P., Petrov K., Kadirov M., Zakharova L., Zueva I., Voloshina A., Nizameev I., Sinyashin O.   +12 more
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Pyrimidine Triones as Potential Activators of p53 Mutants

Biomolecules
p53 is a crucial tumor suppressor in vertebrates that is frequently mutated in human cancers. Most mutations are missense mutations that render p53 inactive in suppressing tumor initiation and progression.
Maryam M. Jebril Fallatah, Özlem Demir, Fiona Law, Linda Lauinger, Roberta Baronio, Linda Hall, Elodie Bournique, Ambuj Srivastava, Landon Tyler Metzen, Zane Norman, Rémi Buisson, Rommie E. Amaro, Peter Kaiser   +12 more
doaj   +1 more source

Reactivity Hypothesis adult reactivity versus child reactivity

The phenomenom of reactivity is such that if one tells a person that the person is recorded each time the person says the word 'like' the person is saying it less than if the person would have not known the word is going to be recorded, i.e. the person being monitored. A good example is described in the book David H. Barlow & V. Mark Durand, 2012, 2009
openaire   +1 more source

Mixed cationic liposomes for brain delivery of drugs by the intranasal route: The acetylcholinesterase reactivator 2-PAM as encapsulated drug model

, 2020
© 2018 Elsevier B.V. New mixed cationic liposomes based on L-α-phosphatidylcholine and dihexadecylmethylhydroxyethylammonium bromide (DHDHAB) were designed to overcome the BBB crossing by using the intranasal route.
Lukashenko S., Pashirova T., Souto E., Almasy L., Kulik N., Masson P., Petrov K., Kadirov M., Zakharova L., Zueva I., Voloshina A., Nizameev I., Sinyashin O.   +12 more
core  

Illuminating the Unseen: Dynamic Butyrylcholinesterase Detection Driving Precision Medicine and Environmental Toxicology

SmartMat
Butyrylcholinesterase (BChE), an essential serine hydrolase playing critical functions in both neurobiological processes and toxicological responses, has gained recognition as a crucial biomarker for detecting hepatic impairment, Alzheimer's disease (AD),
Min Liu, Shuaige Bai, Shuai Huang, Ting Luo, Yiyang Zhou, Meihui Liu, Xueping Feng, Wenbin Zeng   +7 more
doaj   +1 more source