Results 51 to 60 of about 124,194 (317)
Imidazole aldoximes effective in assisting butyrylcholinesterase catalysis of organophosphate detoxification. [PDF]
, 2014 Intoxication by organophosphate (OP) nerve agents and pesticides should be addressed by efficient, quickly deployable countermeasures such as antidotes reactivating acetylcholinesterase or scavenging the parent OP.
Amitai, Gabriel +5 more
core
Repeated batch for dye degradation in an airlift bioreactor by laccase entrapped in copper alginate [PDF]
, 2017 A repeated batch of synthetic dye decolorization was efficiently demonstrated in a 5 L airlift bioreactor. A laccase from Ganoderma sp. KU-Alk4, degrading commercial aromatic dyes was selected. The crude enzyme extract expressed laccase activity, and was
Chitradon, L. +7 more
core +1 more source
Polish Archives of Internal Medicine, 2009 Reactive arthritis (ReA) is a non-purulent joint inflammation that usually follows bacterial gastrointenstinal or urogenital infections. The classic presentation of ReA is characterized by an asymmetric arthritis usually in the lower limbs associated with urethritis, conjunctivitis and occurrence of other articular or extra-articular manifestations ...
Brygida, Kwiatkowska +1 more
openaire +2 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
New Uncharged 2-Thienostilbene Oximes as Reactivators of Organophosphate-Inhibited Cholinesterases
Pharmaceuticals, 2021 The inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) by organophosphates (OPs) as nerve agents and pesticides compromises normal cholinergic nerve signal transduction in the peripheral and central nervous systems (CNS) leading ...
Milena Mlakić +8 more
doaj +1 more source
Autophagy in the light of sphingolipid metabolism [PDF]
, 2015 Maintenance of cellular homeostasis requires tight and coordinated control of numerous metabolic pathways, which are governed by interconnected networks of signaling pathways and energy-sensing regulators.
Færgeman, Nils J. +2 more
core +2 more sources
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Anticholinergic Drugs – Functional Antidotes for the Treatment of Tabun Intoxication
Acta Medica, 2004 Summary: 1. To study the influence of antidotes on tabun-induced neurotoxicity, the rats were injected intramuscularly with organophosphate tabun (LD50).
Gabriela Krejčová, Jiří Kassa
doaj +1 more source
Counteracting poisoning with chemical warfare nerve agents
Arhiv za Higijenu Rada i Toksikologiju, 2020 Phosphylation of the pivotal enzyme acetylcholinesterase (AChE) by nerve agents (NAs) leads to irreversible inhibition of the enzyme and accumulation of neurotransmitter acetylcholine, which induces cholinergic crisis, that is, overstimulation of ...
Hrvat Nikolina Maček, Kovarik Zrinka
doaj +1 more source
Interleukin 1 is a key driver of inflammatory bowel disease-demonstration in a murine IL-1Ra knockout model [PDF]
, 2019 Interleukin 1 (IL-1) is an important mediator of inflammation and tissue damage in inflammatory bowel disease (IBD). The balance between IL-1 and IL-1Ra as a natural inhibitor plays a vital role in a variety of diseases.
Al-Hassi +47 more
core +1 more source