Results 51 to 60 of about 1,554 (191)

Synthesis and Molecular Properties of Nerve Agent Reactivator HLö‑7 Dimethanesulfonate

, 2019
The threat of a deliberate release of chemical nerve agents has underscored the need to continually improve field effective treatments for these types of poisonings. The oxime containing HLö-7 is a potential second-generation therapeutic reactivator.
Jack McGuire, Andrew J. Walz (2229286), Jude J. Height, Andrew J. Walz, Jude J. Height (2019472), Dana R Anderson (6542027), Su Y. Bae, Stephanie M. Bester (5374688), Stephanie M. Bester, Scott D. Pegan (832047), Dana R Anderson, Su Y. Bae (1938868), Scott D. Pegan, Fu-Lian Hsu (2733364), Jack McGuire (6542024), Fu-Lian Hsu   +15 more
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Reactive arthritis

European Journal of Case Reports in Internal Medicine
Reactive arthritis is a form of seronegative spondylarthritis that presents following an infection, with clear associations to specific microorganisms. It is a rare entity and typically affects young adults. An 88-year-old woman, admitted in our ward with pseudomembranous enterocolitis and acute renal lesion, presented with axial oligoarthritis on the ...
Carolina António Santos, Frederico Trigueiros, Inês Machado Leite   +2 more
openaire   +3 more sources

Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction

, 2022
The mechanism of action of eprenetapopt (APR-246, PRIMA-1(MET)) as an anticancer agent remains unresolved, although the clinical development of eprenetapopt focuses on its reported mechanism of action as a mutant-p53 reactivator.
Fujihara, Asuka T., Kearney, Conor J., Ang, Ching-Seng, Cabalag, Carlos S., Jackson, Thomas D., Simpson, Kaylene J., Haupt, Sue, Sutton, Vivien R., Nijagal, Brunda, Watt, Sally, Stojanovski, Diana, Phillips, Wayne A., Leimkühler, Silke (Prof. Dr.), Milne, Julia V., Hogg, Simon J., Clemons, Nicholas J., Ogunkola, Moses O., Ogunkola, Moses (Dr.), Leimkühler, Silke, Sallman, David A., Trapani, Joseph A., Fujihara, Kenji M., Zhang, Bonnie Z., Nikolic, Iva   +23 more
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Oxime Therapy for Brain AChE Reactivation and Neuroprotection after Organophosphate Poisoning

Pharmaceutics, 2022
One of the main problems in the treatment of poisoning with organophosphorus (OPs) inhibitors of acetylcholinesterase (AChE) is low ability of existing reactivators of AChE that are used as antidotes to cross the blood-brain barrier (BBB).
Darya A. Kuznetsova, Gulnara A. Gaynanova, Elmira A. Vasilieva, Rais V. Pavlov, Irina V. Zueva, Vasily M. Babaev, Denis M. Kuznetsov, Alexandra D. Voloshina, Konstantin A. Petrov, Lucia Y. Zakharova, Oleg G. Sinyashin   +10 more
doaj   +1 more source

Pralidoxime in organophosphorus poisoning

Journal of Nepal Medical Association, 2010
INTRODUCTION: Pralidoxime are enzyme reactivator that are known to reactivate the phosphorylated acetylcholinesterase by binding to the organophosphorus molecule.
N R Simkhada, KK Kafle, PN Prasad
doaj   +1 more source

Synthesis and biological evaluation of novel uncharged cholinesterase reactivator against nerve agent intoxication [PDF]

, 2019
Charles University Faculty of Pharmacy in Hradec Králové Department of Organic and Bioorganic Chemistry Student: Mojmír Vaněk Supervisor: doc. PharmDr. Jaroslav Roh Ph.D. Advisors: PharmDr. Jan Korábečný Ph.D.; PharmDr. Vendula Hepnarová Ph.D.
Vaněk, Mojmír
core  

The bispyridinium-dioxime HLö-7. A potent reactivator for acetylcholinesterase inhibited by the stereoisomers of tabun and soman

, 1989
Purification of (+)-tabun was accomplished by treatment with electric eel acetylcholinesterase (AChE) in order to bind contaminating (-)-tabun, the more potent enantiomer with respect of AChE inhibition.
Jong, L.P.A.de, Verhagen, M.A.A., Hagedorn, I., Langenberg, J.P., Löffler, M.   +4 more
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PP2A‐based triple‐strike therapy overcomes mitochondrial apoptosis resistance in brain cancer cells

Molecular Oncology, 2023
Mitochondrial glycolysis and hyperactivity of the phosphatidylinositol 3‐kinase–protein kinase B (AKT) pathway are hallmarks of malignant brain tumors.
Oxana V. Denisova, Joni Merisaari, Riikka Huhtaniemi, Xi Qiao, Laxman Yetukuri, Mikael Jumppanen, Amanpreet Kaur, Mirva Pääkkönen, Сarina vonSchantz‐Fant, Michael Ohlmeyer, Krister Wennerberg, Otto Kauko, Raphael Koch, Tero Aittokallio, Mikko Taipale, Jukka Westermarck   +15 more
doaj   +1 more source

Reactivating a Reactivation Theory of Implicit Memory

Consciousness and Cognition, 1996
Implicit and explicit memory tasks are interpreted within a traditional memory theory that distinguishes associations between different classes of memory units (sensory features, logogens, imagines, concepts, context tags). Associations from specific sensory features to logogens are strengthened by perceptual experiences, leading to specific perceptual
openaire   +2 more sources

Reactive arthritis

Polish Archives of Internal Medicine, 2009
Reactive arthritis (ReA) is a non-purulent joint inflammation that usually follows bacterial gastrointenstinal or urogenital infections. The classic presentation of ReA is characterized by an asymmetric arthritis usually in the lower limbs associated with urethritis, conjunctivitis and occurrence of other articular or extra-articular manifestations ...
Brygida, Kwiatkowska, Anna, Filipowicz-Sosnowska   +1 more
openaire   +2 more sources