Results 21 to 30 of about 1,698 (291)

EFFECTIVENESS OF DECOY WATER TREATMENT ON REACTIVATORS AT PT GOODYEAR INDONESIA Tbk

Al-Ulum, 2023
PT Goodyear Indonesia Tbk is a tire manufacturing industry whose main need is the provision of water for steam boiler decoys. This water is obtained from groundwater and surface water such as river water which is then treated in a reactivator using one ...
Sri Murda Niati, Guruh Akbar, Gemala Cahya   +2 more
doaj   +1 more source

A Reactivator of Organophosphorus Nerve Agent-Inhibited Human Acetylcholinesterase: Characterization, Mechanistic Insights and Design

, 2022
Koh, John T.Organophosphorus nerve agents are highly toxic compounds which pose a threat worldwide. These compounds induce toxicity by covalently binding to the active site serine of acetylcholinesterase, which results in inhibition of the enzyme ...
Cadieux, C. Linn
core   +1 more source

Discovery of Rezatapopt (PC14586), a First-in-Class, Small-Molecule Reactivator of p53 Y220C Mutant in Development [PDF]

ACS Medicinal Chemistry Letters
Thomas W Davis, Romyr Dominique, Bruce J Fahr   +2 more
exaly   +2 more sources

Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and butyrylcholinesterase reactivators

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
The series of symmetrical and unsymmetrical isoquinolinium-5-carbaldoximes was designed and prepared for cholinesterase reactivation purposes. The novel compounds were evaluated for intrinsic acetylcholinesterase (AChE) or butyrylcholinesterase (BChE ...
David Malinak, Rafael Dolezal, Vendula Hepnarova, Miroslava Hozova, Rudolf Andrys, Petr Bzonek, Veronika Racakova, Jan Korabecny, Lukas Gorecki, Eva Mezeiova, Miroslav Psotka, Daniel Jun, Kamil Kuca, Kamil Musilek   +13 more
doaj   +1 more source

Distributed Reactive Programming for Reactive Distributed Systems [PDF]

The Art, Science, and Engineering of Programming, 2019
Context: The term reactivity is popular in two areas of research: programming languages and distributed systems. On one hand, reactive programming is a paradigm which provides programmers with the means to declaratively write event-driven applications. On the other hand, reactive distributed systems handle client requests in a timely fashion regardless
Florian Myter, Christophe Scholliers, Wolfgang De Meuter   +2 more
openaire   +4 more sources

In silico studies in probing the role of kinetic and structural effects of different drugs for the reactivation of tabun-inhibited AChE. [PDF]

PLoS ONE, 2013
We have examined the reactivation mechanism of the tabun-conjugated AChE with various drugs using density functional theory (DFT) and post-Hartree-Fock methods. The electronic environments and structural features of neutral oximes (deazapralidoxime and 3-
Rabindranath Lo, Nellore Bhanu Chandar, Manoj K Kesharwani, Aastha Jain, Bishwajit Ganguly   +4 more
doaj   +1 more source

Novel Bisquaternary Oximes—Reactivation of Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon

Molecules, 2009
Four novel bisquaternary aldoxime cholinesterase reactivators differing in their chemical structure were prepared. Afterwards, their biological activity was evaluated for their ability to reactivate acetylcholinesterase (AChE; EC 3.1.1.7) and ...
Daniel Jun, Jana Zdarova Karasova, Miroslav Pohanka, Martina Hrabinova, Kamil Musilek, Martin Paar, Vladimir Cirkva, Jiri Palecek, Kamil Kuca, Lucie Musilova   +9 more
doaj   +1 more source

Reactive scripts

Proceedings of 3rd International Workshop on Real-Time Computing Systems and Applications, 2002
A reactive script interpretor is a broadcast event-driven interpretor which can react to several commands in parallel. The basic principle is that absence of an event cannot be decided before the end of the current interpretor reaction. Generating events and waiting for occurrence of events are the basic commands which are composed in several ways to ...
Boussinot, Frédéric, Hazard, Laurent
openaire   +2 more sources

Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction

, 2022
The mechanism of action of eprenetapopt (APR-246, PRIMA-1(MET)) as an anticancer agent remains unresolved, although the clinical development of eprenetapopt focuses on its reported mechanism of action as a mutant-p53 reactivator.
Fujihara, Asuka T., Kearney, Conor J., Ang, Ching-Seng, Cabalag, Carlos S., Jackson, Thomas D., Simpson, Kaylene J., Haupt, Sue, Sutton, Vivien R., Nijagal, Brunda, Watt, Sally, Stojanovski, Diana, Phillips, Wayne A., Leimkühler, Silke (Prof. Dr.), Milne, Julia V., Hogg, Simon J., Clemons, Nicholas J., Ogunkola, Moses O., Ogunkola, Moses (Dr.), Leimkühler, Silke, Sallman, David A., Trapani, Joseph A., Fujihara, Kenji M., Zhang, Bonnie Z., Nikolic, Iva   +23 more
core   +2 more sources

The pioneering scientific endeavor and contributions of José María González Benito (1843-1903), the first Colombian modern astronomer

Revista de la Academia Colombiana de Ciencias Exactas, Físicas y Naturales, 2022
Astronomical interest within the current Colombian territory has its roots in the Botanical Expedition of the New Kingdom of Granada (1783-1813), which stimulated the creation of an astronomical observatory in 1803, the first one established in the New ...
Freddy Moreno-Cárdenas, Santiago Vargas-Domínguez, Jorge Cuéllar-Moyano   +2 more
doaj   +1 more source