Results 21 to 30 of about 124,194 (317)
MIRA-1, a p53mut reactivator, is active on Temozolomide-resistant glioblastoma in vitro [PDF]
Molecular BiomedicineJuan Perdomo +4 more
doaj +2 more sources
EFFECTIVENESS OF DECOY WATER TREATMENT ON REACTIVATORS AT PT GOODYEAR INDONESIA Tbk
Al-Ulum, 2023 PT Goodyear Indonesia Tbk is a tire manufacturing industry whose main need is the provision of water for steam boiler decoys. This water is obtained from groundwater and surface water such as river water which is then treated in a reactivator using one ...
Sri Murda Niati +2 more
doaj +1 more source
Pharmacology and Therapeutics, 2022 The retinoblastoma gene (RB) was discovered as the first tumor-suppressor gene. It was subsequently shown to be inactivated in most malignant tumors, particularly at the protein level.
Toshiyuki Sakai
semanticscholar +1 more source
Mixed cationic liposomes for brain delivery of drugs by the intranasal route: The acetylcholinesterase reactivator 2-PAM as encapsulated drug model. [PDF]
Colloids and Surfaces B: Biointerfaces, 2018 New mixed cationic liposomes based on L-α-phosphatidylcholine and dihexadecylmethylhydroxyethylammonium bromide (DHDHAB) were designed to overcome the BBB crossing by using the intranasal route. Synthesis and self-assembly of DHDHAB were performed. A low
T. Pashirova +12 more
semanticscholar +1 more source
International Journal of STD & AIDS, 1994 Reactive arthritis (ReA) develops after an infection elsewhere in the body, generally in the genitourinary or intestinal tract. Chlamydia trachomatis, Yersinia enterocolitica, salmonella, shigella, and campylobacter are frequent triggering agents. Between 60% and 90% of patients are positive for HLA-B27.
openaire +3 more sources
Transitioning from Oxime to the Next Potential Organophosphorus Poisoning Therapy Using Enzymes
Journal of Chemistry, 2021 For years, organophosphorus poisoning has been a major concern of health problems throughout the world. An estimated 200,000 acute pesticide poisoning deaths occur each year, many in developing countries.
Rauda A. Mohamed +7 more
doaj +1 more source
Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1:a novel anticancer small-molecule [PDF]
, 2015 Restoration of the p53 pathway, namely by reactivation of mutant (mut) p53, represents a valuable anticancer strategy. Herein, we report the identification of the enantiopure tryptophanol-derived oxazoloisoindolinone SLMP53-1 as a novel reactivator of ...
Bessa, Cláudia +15 more
core +3 more sources
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 The series of symmetrical and unsymmetrical isoquinolinium-5-carbaldoximes was designed and prepared for cholinesterase reactivation purposes. The novel compounds were evaluated for intrinsic acetylcholinesterase (AChE) or butyrylcholinesterase (BChE ...
David Malinak +13 more
doaj +1 more source
Acta Medica, 2010 The studies dealing with mechanism of organophosphates (OP)/nerve agent action, prophylaxis and treatment of intoxications is a very hot topic at present.
Jiří Bajgar
doaj +1 more source
In silico studies in probing the role of kinetic and structural effects of different drugs for the reactivation of tabun-inhibited AChE. [PDF]
PLoS ONE, 2013 We have examined the reactivation mechanism of the tabun-conjugated AChE with various drugs using density functional theory (DFT) and post-Hartree-Fock methods. The electronic environments and structural features of neutral oximes (deazapralidoxime and 3-
Rabindranath Lo +4 more
doaj +1 more source