Results 31 to 40 of about 26,803 (327)

Development of a Larval Zebrafish Model for Acute Organophosphorus Nerve Agent and Pesticide Exposure and Therapeutic Evaluation

Toxics, 2020
Organophosphorus compound exposure remains a present threat through agricultural accidents, warfare, or terrorist activity. The primary mechanism of organophosphorus toxicity is through inhibition of the enzyme acetylcholinesterase, with current ...
Jeffrey A. Koenig, Cindy Acon Chen, Tsung-Ming Shih   +2 more
doaj   +1 more source

Reactivation Potency of New Group of Acetylcholinesterase Reactivators and Their Comparison with Currently Available Oximes

Acta Medica, 2006
In this work, in vitro potency of novel serie of monoquaternary pyridinium oximes to reactivate cyclosarin-inhibited acetylcholinesterase (AChE) was tested.
Kamil Kuča, Jan Pícha, Daniel Jun
doaj   +1 more source

Molecular Modeling and In Vitro Studies of a Neutral Oxime as a Potential Reactivator for Acetylcholinesterase Inhibited by Paraoxon

Molecules, 2018
The present work aimed to compare the small, neutral and monoaromatic oxime, isatin-3-oxime (isatin-O), to the commercial ones, pralidoxime (2-PAM) and obidoxime, in a search for a new potential reactivator for acetylcholinesterase (AChE) inhibited by ...
Reuel L. de Paula, Joyce S. F. D. de Almeida, Samir F. A. Cavalcante, Arlan S. Gonçalves, Alessandro B. C. Simas, Tanos C. C. Franca, Martin Valis, Kamil Kuca, Eugenie Nepovimova, José M. Granjeiro   +9 more
doaj   +1 more source

The Synthetic Curcumin Analog HO-3867 Rescues Suppression of PLAC1 Expression in Ovarian Cancer Cells

Pharmaceuticals, 2021
Elevated expression of placenta-specific protein 1 (PLAC1) is associated with the increased proliferation and invasiveness of a variety of human cancers, including ovarian cancer.
Eric J. Devor, Brandon M. Schickling, Jace R. Lapierre, David P. Bender, Jesus Gonzalez-Bosquet, Kimberly K. Leslie   +5 more
doaj   +1 more source

Repeated batch for dye degradation in an airlift bioreactor by laccase entrapped in copper alginate [PDF]

, 2017
A repeated batch of synthetic dye decolorization was efficiently demonstrated in a 5 L airlift bioreactor. A laccase from Ganoderma sp. KU-Alk4, degrading commercial aromatic dyes was selected. The crude enzyme extract expressed laccase activity, and was
Chitradon, L., Chitradon, L., Keshavarz, T., Keshavarz, T., Parra, R., Parra, R., Teerapatsakul, C., Teerapatsakul, C.   +7 more
core   +1 more source

reactive (reactivity) [PDF]

, 2014
Citation: 'reactive (reactivity)' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.R05180 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

An Efficient Synthesis of Pyridoxal Oxime Derivatives under Microwave Irradiation [PDF]

, 2014
Quaternary salts of pyridoxal oxime have been synthesized by the quaternization of pyridoxal oxime with substituted phenacyl bromides using microwave heating.
Bušić, Valentina, Cetina, Mario, Gašo-Sokač, Dajana, Jukić, Marijana   +3 more
core   +4 more sources

1,3–Bis(2–hydroxyiminomethylpyridinium) Propane as the Potential Reactivator of the Acetylcholinesterase Inhibited by Nerve Agents

Acta Medica, 2004
The oxime K005 [1,3–bis(2–hydroxyiminomethylpyridinium) propane dibromide] for the reactivation of the enzyme acetylcholinesterase (AChE) inhibited by cyclosarin and VX was tested.
Kamil Kuča, Vlastimil Dohnal
doaj   +1 more source

Kvalitativna procjena eliminacije TCP-a i TAMORF-a iz organizma štakora metodom GC-MS [PDF]

, 2010
Nerve agents are highly toxic organophosphorus (OP) compounds. They inhibit acetylcholinesterase (AChE), an enzyme that hydrolyses acetycholine (ACh) in the nervous system.
A. Lucić Vrdoljak, A. Lucić Vrdoljak, Ana Vrdoljak, B Radić, B. Capacio, B. Williams, D. Škare, E. Johnson, F. Worek, G. Lallement, G. Lallement, Gordan Mršić, H. Okudera, J. Bajgar, L. McCauley, M. Petek, M. Srivatsan, Maja Petek, N. Kawana, P. Carpentier, P. Taylor   +20 more
core   +2 more sources

Computational Design, Molecular Docking Study and Toxicity Prediction of Some Novel Pralidoxime Derivatives as reactivators of acetyl cholinesterase enzyme [PDF]

Journal of Advanced Biomedical Sciences, 2019
Background & Objective: oximes as Acetylcholinesterase (AChE) reactivators were developed for the treatment of organophosphate compounds (OPCs) intoxication.
abozar roeintan
doaj