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Aging and the Role of Reactive Nitrogen Species

Annals of the New York Academy of Sciences, 2002
AbstractThe role of reactive oxygen species and its effects on aging has received considerable attention in the past 47 years since Dr. Denham Harman first proposed the “free radical theory of aging.” Though not completely understood due to the incalculable number of pathways involved, the number of manuscripts that facilitate the understanding of the ...
Barry, Drew, Christiaan, Leeuwenburgh
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Reactive nitrogen species in the respiratory tract

European Journal of Pharmacology, 2006
Endogenous Nitric Oxide (NO) plays a key role in the physiological regulation of airway functions. In response to various stimuli activated inflammatory cells (e.g., eosinophils and neutrophils) generate oxidants ("oxidative stress") which in conjunction with exaggerated enzymatic release of NO and augmented NO metabolites produce the formation of ...
Ricciardolo, F.L.M.   +3 more
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Reactive Nitrogen Species in Colon Carcinogenesis

Antioxidants & Redox Signaling, 1999
The role of reactive nitrogen species (RNS) in colon carcinogenesis is multifactorial and affects diverse processes, such as proliferation, apoptosis, differentiation, tumorigenesis, and metastases. This review describes the stages in colon carcinogenesis where nitric oxide (NO) and inducible NO synthase (NOS2) may influence the progression of a normal
C M, Payne   +4 more
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Reactive Oxygen and Nitrogen Species

Nursing Research, 2015
Reactive oxygen and nitrogen species, known as free radicals, play a key role in the etiology and progression of atherosclerotic cardiovascular disease by creating vascular oxidative stress.This review will discuss current biological research about the enzymatic and nonenzymatic sources of oxidative stress, free radical chemistry, and how it pertains ...
Dereck, Salisbury, Ulf, Bronas
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Carbon dots as Reactive Nitrogen Species nanosensors

Analytica Chimica Acta, 2022
Three sets of Carbon Dots (Cdots) were produced through the carbohydrates acid thermal decomposition method. These nanoparticles were functionalized with a polymer, known for its biological compatibility: polyethylene glycol, PEG200, and folic acid, FA, a biomolecule associated with the reactive oxygen and nitrogen (ROS/RNS) savaging process, thus ...
Marita A. Cardoso   +2 more
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THE REACTIVE SPECIES IN ACTIVE NITROGEN

Canadian Journal of Chemistry, 1962
A study has been made of the discrepancy between the N-atom content of active nitrogen as inferred from the maximum HCN production from the reaction of many hydrocarbons, and that indicated by the extent of NO destruction. The HCN production from several hydrocarbons was similar at high reaction temperatures in a spherical reaction vessel, and was ...
A. N. Wright   +2 more
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Detection of reactive oxygen and reactive nitrogen species in skeletal muscle

Microscopy Research and Technique, 2001
AbstractReactive oxygen species (ROS) and reactive nitrogen species (RNS) are usually identified with pathological states and mediators of cellular injury. However, over the last decade ROS and RNS have been identified in skeletal muscle under physiological conditions.
C L, Murrant, M B, Reid
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Clinical aspects of reactive oxygen and nitrogen species

Biochemical Society Symposia, 2004
Endothelial dysfunction in the setting of cardiovascular risk factors, such as hypercholesterolaemia, hypertension, diabetes mellitus and chronic smoking, as well as in the setting of heart failure, has been shown to be at least partly dependent on the production of reactive oxygen species in endothelial and/or smooth muscle cells and the adventitia ...
Ascan, Warnholtz   +3 more
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Reactive oxygen and nitrogen species: Friends or foes?

Biochemistry (Moscow), 2005
Chemical and physiological functions of molecular oxygen and reactive oxygen species (ROS) and existing equilibrium between pools of pro-oxidants and anti-oxidants providing steady state ROS level vital for normal mitochondrial and cell functioning are reviewed.
D B, Zorov   +7 more
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Ras Regulation by Reactive Oxygen and Nitrogen Species

Biochemistry, 2006
Ras GTPases cycle between inactive GDP-bound and active GTP-bound states to modulate a diverse array of processes involved in cellular growth control. We have previously shown that both NO/O(2) (via nitrogen dioxide, (*)NO(2)) and superoxide radical anion (O(2)(*)(-)) promote Ras guanine nucleotide dissociation.
Jongyun, Heo, Sharon L, Campbell
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