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Aging and the Role of Reactive Nitrogen Species
Annals of the New York Academy of Sciences, 2002AbstractThe role of reactive oxygen species and its effects on aging has received considerable attention in the past 47 years since Dr. Denham Harman first proposed the “free radical theory of aging.” Though not completely understood due to the incalculable number of pathways involved, the number of manuscripts that facilitate the understanding of the ...
Barry, Drew, Christiaan, Leeuwenburgh
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Transthyretin Aggregates Induce Production of Reactive Nitrogen Species
Neurodegenerative Diseases, 2012<b><i>Background and Objective:</i></b> Misfolded and aggregated transthyretins (agTTR) contribute to neurodegenerative amyloid diseases such as familial amyloid polyneuropathy and senile systemic amyloidosis. The neurotoxicity mechanisms of agTTR, however, are not well understood. In the current study, the possible contribution
Vai-Hong, Fong, Amandio, Vieira
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Imaging of Intracellular Reactive Nitrogen Species and Reactive Sulfur Species
2020This chapter summarizes representative small-molecule fluorescent probes for reactive nitrogen species and reactive sulfur species in living cells. The design and response mechanisms of the probes are described in detail. Probes that have not been applied in living cell analysis are not included.
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Reactive nitrogen and oxygen species in airway inflammation
European Journal of Pharmacology, 2001The free radical nitric oxide (NO) is an important mediator of many biological processes. Interestingly, the molecule appears to be a two-edged sword. Apart from NO having a function as a paracrine messenger, NO-derived oxidants are important weapons against invading pathogens. The role of NO in the airways is similarly ambiguous. Besides the task as a
Folkerts, G. +3 more
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Reactive oxygen species, reactive nitrogen species and redox signalling
2016This chapter explains our current understanding of how reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated and perceived, and how they propagate their messages. It argues that the main components involved here include those used in phosphorylation and cyclic nucleotides.
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[Reactive nitrogen and oxygen species].
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2010Reactive nitrogen species (RNS) and reactive oxygen species (ROS) are mainly free radicals which including non-paired electrons. They are constantly formed as side products of biological reactions. They are also generated directly and indirectly by the cells which were exposed to environmental stress, i.e., UV radiation, ionizing radiation ...
Helena, Puzanowska-Tarasiewicz +2 more
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Nitric Oxide and Reactive Nitrogen Species
2014Nitric oxide (NO) plays a key role in plant metabolism, signaling, defense, and development. However, a fundamental question arises how the NO message is converted into a physiological response. NO-related signaling may be attributed to various NO derivatives, collectively named reactive nitrogen species (RNS).
Magdalena Arasimowicz-Jelonek +3 more
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Clinical aspects of reactive oxygen and nitrogen species
Biochemical Society Symposia, 2004Endothelial dysfunction in the setting of cardiovascular risk factors, such as hypercholesterolaemia, hypertension, diabetes mellitus and chronic smoking, as well as in the setting of heart failure, has been shown to be at least partly dependent on the production of reactive oxygen species in endothelial and/or smooth muscle cells and the adventitia ...
Ascan, Warnholtz +3 more
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Reactive oxygen and nitrogen species: Friends or foes?
Biochemistry (Moscow), 2005Chemical and physiological functions of molecular oxygen and reactive oxygen species (ROS) and existing equilibrium between pools of pro-oxidants and anti-oxidants providing steady state ROS level vital for normal mitochondrial and cell functioning are reviewed.
D B, Zorov +7 more
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Reactive Oxygen and Nitrogen Species
2004The term “radical” is often used loosely in chemistry to refer to various groups of atoms that behave as a unit, such as the carbonate radical (CO 3 sup2- ), nitrate radical (NO 3 sup- ), and the methyl radical (CH3p-). According to this definition, Lavoisier (1789) has already indicated that the four elements: phosphorus, sulphur, carbon, and hydrogen
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