Results 41 to 50 of about 5,566,634 (283)

Antioxidants and skeletal muscle performance: ’Common knowledge’ vs. experimental evidence.

Frontiers in Physiology, 2012
Antioxidants are assumed to provide numerous benefits, including better health, a reduced rate of aging, and improved exercise performance. Specifically, antioxidants are commonly ‘prescribed’ by the media, supplement industry, and ‘fitness experts’ for
Andrés eHernández, Arthur J. Cheng, Håkan eWesterblad   +2 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Evaluation of melatonin levels in saliva in periodontal health and disease: A clinico-biochemical study

Journal of International Clinical Dental Research Organization, 2010
Background: Melatonin, a secretory product of the vertebrate pineal gland, activates several elements of the immune system that reduce tissue destruction during the inflammatory response, either directly by scavenging free radical, reactive oxygen ...
Nilkanth Mhaske, Pramod Marawar, Anand Sheker, Nilesh Mote   +3 more
doaj   +1 more source

Reactive Nitrogen Species Reactivities with Nitrones: Theoretical and Experimental Studies [PDF]

Chemical Research in Toxicology, 2012
Reactive nitrogen species (RNS) such as nitrogen dioxide ((•)NO(2)), peroxynitrite (ONOO(-)), and nitrosoperoxycarbonate (ONOOCO(2)(-)) are among the most damaging species present in biological systems due to their ability to cause modification of key biomolecular systems through oxidation, nitrosylation, and nitration.
Kevin M, Nash, Antal, Rockenbauer, Frederick A, Villamena   +2 more
openaire   +2 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

High functional diversity is related to high nitrogen availability in a deciduous forest - evidence from a functional trait approach [PDF]

, 2010
The current study tested the assumption that floristic and functional diversity patterns are negatively related to soil nitrogen content. We analyzed 20 plots with soil N-contents ranging from 0.63% to 1.06% in a deciduous forest near Munich (Germany ...
Fischer, Anton, Kudernatsch, Thomas, Bernhardt-Roemermann, Markus, Roemermann, Christine, Patta Pillar, Valério de, Christine Römermann, Anton Fischer, Thomas Kudernatsch, Römermann, Christine, Valério DePatta Pillar, Pillar, Valerio D., Markus Bernhardt-Römermann, Bernhardt-Römermann, Markus   +12 more
core   +1 more source

Photoactivatable nanogenerators of reactive species for cancer therapy

Bioactive Materials, 2021
In recent years, reactive species-based cancer therapies have attracted tremendous attention due to their simplicity, controllability, and effectiveness.
Xiaohua Zheng, Ph.D., Yilan Jin, Xiao Liu, Tianqing Liu, Ph.D., Weiqi Wang, Ph.D., Haijun Yu, Ph.D.   +5 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Glutathione Participation in the Prevention of Cardiovascular Diseases

Antioxidants, 2021
Cardiovascular diseases (CVD) (such as occlusion of the coronary arteries, hypertensive heart diseases and strokes) are diseases that generate thousands of patients with a high mortality rate worldwide.
Deyamira Matuz-Mares, Héctor Riveros-Rosas, María Magdalena Vilchis-Landeros, Héctor Vázquez-Meza   +3 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source