Results 1 to 10 of about 82,947 (75)

Respiratory Viruses and Virus-like Particle Vaccine Development: How Far Have We Advanced?

Viruses, 2023
With technological advancements enabling globalization, the intercontinental transmission of pathogens has become much easier. Respiratory viruses are one such group of pathogens that require constant monitoring since their outbreak leads to massive ...
Ki-Back Chu, Fu-Shi Quan
doaj   +1 more source

Glutathione Peroxidase 8 Suppression by Histone Deacetylase Inhibitors Enhances Endoplasmic Reticulum Stress and Cell Death by Oxidative Stress in Hepatocellular Carcinoma Cells

Antioxidants, 2021
Histone deacetylase inhibitors (HDACi) are emerging as anti-hepatocellular carcinoma (HCC) agents. However, the molecular mechanisms underlying HDACi-induced sensitization to oxidative stress and cell death of HCC remain elusive.
Hae-Ahm Lee, Ki-Back Chu, Eun-Kyung Moon, Fu-Shi Quan   +3 more
doaj   +1 more source

Advances in Toxoplasma gondii Vaccines: Current Strategies and Challenges for Vaccine Development

Vaccines, 2021
Toxoplasmosis, caused by the apicomplexan parasite Toxoplasma gondii, is one of the most damaging parasite-borne zoonotic diseases of global importance.
Ki-Back Chu, Fu-Shi Quan
doaj   +1 more source

Influenza Virus-like Particle (VLP) Vaccines Expressing the SARS-CoV-2 S Glycoprotein, S1, or S2 Domains

Vaccines, 2021
The ongoing severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic had brought disastrous consequences throughout the entire world. While several manufactured vaccines have been approved for emergency use, continuous efforts to generate ...
Ki-Back Chu, Hae-Ji Kang, Keon-Woong Yoon, Hae-Ahm Lee, Eun-Kyung Moon, Beom-Ku Han, Fu-Shi Quan   +6 more
doaj   +1 more source

Sublingual Vaccination with Live Influenza Virus Induces Better Protection Than Oral Immunization in Mice

Life, 2022
Both sublingual (SL) and oral vaccine administration modalities are convenient, easy, and safe. Here, we have investigated the differences in vaccine efficacy that are induced by oral and sublingual immunization with live influenza virus (A/Hong Kong/1 ...
Jie Mao, Gi-Deok Eom, Keon-Woong Yoon, Hae-Ji Kang, Ki-Back Chu, Fu-Shi Quan   +5 more
doaj   +1 more source

Recombinant Vaccinia Virus Expressing Plasmodium berghei Apical Membrane Antigen 1 or Microneme Protein Enhances Protection against P. berghei Infection in Mice

Tropical Medicine and Infectious Disease, 2022
Recombinant vaccinia viruses (rVV) are effective antigen delivery vectors and are researched widely as vaccine platforms against numerous diseases. Apical membrane antigen 1 (AMA1) is one of the candidate antigens for malaria vaccines but rising concerns
Min-Ju Kim, Ki-Back Chu, Su-Hwa Lee, Hae-Ji Kang, Keon-Woong Yoon, Md Atique Ahmed, Fu-Shi Quan   +6 more
doaj   +1 more source

Preliminary Trichinella spiralis Infection Ameliorates Subsequent RSV Infection-Induced Inflammatory Response

Cells, 2020
Respiratory syncytial virus (RSV) infection affects the lives of neonates throughout the globe, causing a high rate of mortality upon hospital admission. Yet, therapeutic options to deal with this pulmonary pathogen are currently limited.
Ki-Back Chu, Hae-Ahm Lee, Hae-Ji Kang, Eun-Kyung Moon, Fu-Shi Quan   +4 more
doaj   +1 more source

Protection Induced by Vaccination with Recombinant Baculovirus and Virus-like Particles Expressing Toxoplasma gondii Rhoptry Protein 18

Vaccines, 2022
Heterologous immunization is garnering attention as a promising strategy to improve vaccine efficacy. Vaccines based on recombinant baculovirus (rBV) and virus-like particle (VLP) are safe for use, but heterologous immunization studies incorporating ...
Keon-Woong Yoon, Ki-Back Chu, Hae-Ji Kang, Min-Ju Kim, Gi-Deok Eom, Jie Mao, Su-Hwa Lee, Md Atique Ahmed, Fu-Shi Quan   +8 more
doaj   +1 more source

Recombinant AMA1 Virus-like Particle Antigen for Serodiagnosis of Toxoplasma gondii Infection

Biomedicines, 2022
Toxoplasmosis diagnosis predominantly relies on serology testing via enzyme-linked immunosorbent assay (ELISA), but these results are highly variable.
Min-Ju Kim, Ki-Back Chu, Jie Mao, Hae-Ji Kang, Gi-Deok Eom, Keon-Woong Yoon, Su-Hwa Lee, Eun-Kyung Moon, Young-Ha Lee, Fu-Shi Quan   +9 more
doaj   +1 more source

Aryl-hydrocarbon receptor binding and the incidence of type 2 diabetes: the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Environmental Health, 2020
Background Persistent organic pollutants (POPs) may cause diabetes, in part through aryl hydrocarbon receptor (AhR) binding. Ensuing mitochondrial dysfunction is postulated to mediate this effect.
Bruce B. Duncan, Cristina D. Castilhos, Paula A. Bracco, Maria I. Schmidt, Sora Kang, Suyeol Im, Hong-Kyu Lee, Álvaro Vigo, Youngmi K. Pak   +8 more
doaj   +1 more source